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anti-Human MTMR6 Antibodies:
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Human Polyclonal MTMR6 Primary Antibody for EIA, WB - ABIN953537
Zou, Chang, Marjanovic, Majerus: MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis. in The Journal of biological chemistry 2009
Show all 4 references for ABIN953537
Luciferase reporter assays confirm MTMR6 as a direct miR (show MYLIP Antibodies)-190b target; miR (show MYLIP Antibodies)-190b-mediated MTMR6 downregulation suggests an important mechanism that could keep infected cells in an activated state, thereby promoting viral replication.
MTMR6, which dephosphorylates PI(3 (show PI3 Antibodies))P to PI, and its binding partner MTMR9 (show MTMR9 Antibodies), are required for macropinocytosis.
results indicate that the cellular localization of MTMR6 is regulated by Rab1B (show RAB1B Antibodies) in the early secretory and autophagic pathways
investigation of MTM1 (show MTM1 Antibodies) and MTMR6 and finding that they use PtdIns(3,5)P2 in addition to PtdIns3P as a substrate in vitro
Identification of myotubularin (show MTM1 Antibodies) as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein (show MTMR12 Antibodies), 3-PAP (show MTMR12 Antibodies).
Data show that KCa3.1 (show KCNN4 Antibodies), which is critical for Ca2 (show CA2 Antibodies)+ influx in reactivated naive T cells and central memory T cells, requires phosphatidylinositol-3 phosphatase for activation and is inhibited by PI(3 (show PI3 Antibodies))P phosphatase myotubularin-related protein 6 (MTMR6).
MTMR9 (show MTMR9 Antibodies) greatly enhances the functions of MTMR6
Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells (By similarity).
myotubularin-related protein 6
, myotubularin related protein 6
, myotubularin-related protein 6-like