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The study demonstrated that PLA2G12A SNPs or haplotypes might influence the susceptibility to schizophrenia in the Han Chinese population from Northeast China.
cellular arachidonate (AA) release and prostaglandin (PG) production are regulated by novel classes of secretory phospholipase A (show HRASLS Proteins)(2)s (sPLA(2 (show PLA2G2A Proteins))s), groups III and XII
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000
phospholipase A2, group XIIA
, GXII sPLA2
, group XII secreted phospholipase A2
, group XIIA secreted phospholipase A2
, group XIIA secretory phospholipase A2
, phosphatidylcholine 2-acylhydrolase 12A
, group XII-1 phospholipase A2