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This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 (show PBX1 Proteins) and that the PBX1 (show PBX1 Proteins)/RNF6 axis can be developed as a novel therapeutic target of leukemia.
Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics
Results describe thet cloning and identification of a novel RNF6 transcriptional splice variant, Spg2 (show PLP1 Proteins), in human development.
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
E3 ubiquitin-protein ligase RNF6
, RING-H2 protein RNF-6
, RLIM-like protein
, RING finger protein 6
, ring finger protein 6