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anti-Human TGFB1I1 Antibodies:
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Dog (Canine) Monoclonal TGFB1I1 Primary Antibody for IF, WB - ABIN968401
Jia, Ransom, Shibanuma, Liu, Welsh, Smoyer: Identification and characterization of hic-5/ARA55 as an hsp27 binding protein. in The Journal of biological chemistry 2001
Show all 4 Pubmed References
Dog (Canine) Monoclonal TGFB1I1 Primary Antibody for IF, WB - ABIN968400
Matsuya, Sasaki, Aoto, Mitaka, Nagura, Ohba, Ishino, Takahashi, Suzuki, Sasaki: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. in The Journal of biological chemistry 1998
Show all 4 Pubmed References
Cow (Bovine) Polyclonal TGFB1I1 Primary Antibody for IHC, WB - ABIN2777947
Miyoshi, Ishiguro, Uemura, Fujinami, Miyamoto, Miyoshi, Kitamura, Kubota: Expression of AR associated protein 55 (ARA55) and androgen receptor in prostate cancer. in The Prostate 2003
Isolated Hic-5(-/-);PyMT CAFs (show TBX1 Antibodies) were defective in stress fiber organization and exhibited reduced contractility. These cells also failed to efficiently deposit and organize the ECM (show MMRN1 Antibodies) in two and three dimensions. This, in turn, impacted three-dimensional MDA-MB-231 tumor cell migration behavior
Hic-5 regulates GR binding site selection by a novel mechanism, exploiting gene-specific requirements for chromatin remodeling enzymes to selectively influence DNA occupancy and gene regulation by a transcription factor.
As aging increased, more ARA55 were expressed in PZ stromal cells, leading to more sensitive androgen/androgen receptor (AR (show AR Antibodies)) signal pathway, then constituting a more feasible environment to cancer cells.
Hic-5 appears to enhance complex formation between MT1-MMP (show MMP14 Antibodies) and FAK (show PTK2 Antibodies) in activated endothelial cells, which likely coordinates matrix proteolysis and cell motility.
Hic-5 plays a central role in the positive feedback ROS (show ROS1 Antibodies)-JNK (show MAPK8 Antibodies) signaling cascade that regulates hepatocellular carcinoma progression.
Hic-5 influences the genomic occupancy of multiple steroid receptors and thereby blocks some aspects of hormonal regulation.
Endothelial Hic-5 plays an important role in the formation of microvilli-like structures and in the interaction between ECs and monocytes, leading to monocyte recruitment and subsequent development of atherosclerosis.
Studies in vitro and in vivo using TGF-beta1 (show TGFB1 Antibodies) and TGFB1I1 shRNA demonstrated that TGFB1I1 is required for TGF-beta (show TGFB1 Antibodies) stimulated EMT (show ITK Antibodies) that contributes to malignant progression of astrocytomas.
Hic-5 siRNA also suppressed TGF-beta2 (show TGFB2 Antibodies)-induced fibrogenic activity and dexamethasone-induced myocilin (show MYOC Antibodies) expression in HTM cells.
Hic5 coordinates AR signaling with adhesion and extracellular matrix contacts to regulate cell behavior in the tumor microenvironment.
paxillin (show PXN Antibodies) and Hic-5 have both redundant and distinctive functions in invadosome formation.
Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta (show TGFB1 Antibodies)/Smad2 (show SMAD2 Antibodies) signaling by upregulation of Smad7 (show SMAD7 Antibodies)
Hic-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice.
Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor (show NR3C1 Antibodies) genome occupancy in a gene-selective manner.
Hic-5 is expressed in B16-F1 murine melanoma cells.
identified Hic-5 as a novel and specific regulatory factor for thrombin (show F2 Antibodies)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.
the HIC-5- and KLF4 (show KLF4 Antibodies)-dependent mechanism transactivates p21(Cip1 (show CDKN1A Antibodies)) in response to anchorage loss
These data identify discrete roles for paxillin (show PXN Antibodies) and Hic-5 in Rac1 and RhoA (show RHOA Antibodies)-dependent cell adhesion formation and maturation; processes essential for productive cell migration.
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
transforming growth factor beta 1 induced transcript 1
, androgen receptor coactivator ARA55
, transforming growth factor beta-1-induced transcript 1 protein-like
, androgen receptor coactivator 55 kDa protein
, androgen receptor-associated protein of 55 kDa
, hydrogen peroxide-inducible clone 5 protein
, transforming growth factor beta-1-induced transcript 1 protein
, TGF beta-stimulated clone 5
, androgen receptor activator of 55 kDa