Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
As aging increased, more ARA55 were expressed in PZ stromal cells, leading to more sensitive androgen/androgen receptor (AR (show AR Proteins)) signal pathway, then constituting a more feasible environment to cancer cells.
Hic-5 appears to enhance complex formation between MT1-MMP (show MMP14 Proteins) and FAK (show PTK2 Proteins) in activated endothelial cells, which likely coordinates matrix proteolysis and cell motility.
Hic-5 plays a central role in the positive feedback ROS (show ROS1 Proteins)-JNK (show MAPK8 Proteins) signaling cascade that regulates hepatocellular carcinoma progression.
Hic-5 influences the genomic occupancy of multiple steroid receptors and thereby blocks some aspects of hormonal regulation.
Endothelial Hic-5 plays an important role in the formation of microvilli-like structures and in the interaction between ECs and monocytes, leading to monocyte recruitment and subsequent development of atherosclerosis.
Studies in vitro and in vivo using TGF-beta1 (show TGFB1 Proteins) and TGFB1I1 shRNA demonstrated that TGFB1I1 is required for TGF-beta (show TGFB1 Proteins) stimulated EMT (show ITK Proteins) that contributes to malignant progression of astrocytomas.
Hic-5 siRNA also suppressed TGF-beta2 (show TGFB2 Proteins)-induced fibrogenic activity and dexamethasone-induced myocilin (show MYOC Proteins) expression in HTM cells.
Hic5 coordinates AR signaling with adhesion and extracellular matrix contacts to regulate cell behavior in the tumor microenvironment.
Hic-5 suppresses senescence and profibrotic activities of myofibroblasts by down-regulating Nox4 (show NOX4 Proteins) expression.
The ubiquitin ligase activity of Cbl (show CBL Proteins)-c by the direct interaction of the LIM (show PDLIM5 Proteins) zinc coordinating domain of Hic5 is demonstrated.
Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta (show TGFB1 Proteins)/Smad2 (show SMAD2 Proteins) signaling by upregulation of Smad7 (show SMAD7 Proteins)
Hic-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice.
Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor (show NR3C1 Proteins) genome occupancy in a gene-selective manner.
Hic-5 is expressed in B16-F1 murine melanoma cells.
identified Hic-5 as a novel and specific regulatory factor for thrombin (show F2 Proteins)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.
the HIC-5- and KLF4 (show KLF4 Proteins)-dependent mechanism transactivates p21(Cip1 (show CDKN1A Proteins)) in response to anchorage loss
These data identify discrete roles for paxillin (show PXN Proteins) and Hic-5 in Rac1 and RhoA (show RHOA Proteins)-dependent cell adhesion formation and maturation; processes essential for productive cell migration.
Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein.
DNA-binding domain acetylation in the TR4 (show NR2C2 Proteins) nuclear receptor by the coregulator ARA55 leads to suppression of TR4 (show NR2C2 Proteins) transactivation
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
transforming growth factor beta 1 induced transcript 1
, androgen receptor coactivator ARA55
, transforming growth factor beta-1-induced transcript 1 protein-like
, androgen receptor coactivator 55 kDa protein
, androgen receptor-associated protein of 55 kDa
, hydrogen peroxide-inducible clone 5 protein
, transforming growth factor beta-1-induced transcript 1 protein
, TGF beta-stimulated clone 5
, androgen receptor activator of 55 kDa