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anti-Human IL-6 Receptor antibody for Mass Cytometry

Recommended IL-6 Receptor Antibody (supplied by: Log in to see )

Antigen
Interleukin-6 Receptor (IL6R) Antibodies
  • CD126
  • gp80
  • IL-6R
  • IL-6R-1
  • IL-6RA
  • il-6ra
  • IL-6Ralpha
  • IL6Q
  • Il6r
  • IL6R
  • IL6R1
  • IL6RA
  • Il6ra
  • IL6RQ
Reactivity
Human
129
58
43
Host
Mouse
86
82
23
15
1
Clonality
Monoclonal
Conjugate
This IL-6 Receptor antibody is conjugated to Alexa Fluor 647
22
14
11
10
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Mass Cytometry (CyTOF)
86
76
72
27
22
15
12
11
11
11
10
9
8
6
4
2
2
1
1
1
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Catalog No. ABIN2657623
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Top referenced anti-IL-6 Receptor antibody for Mass Cytometry

Similar anti-IL-6 Receptor Antibodies

Application / Reactivity Human
ELISA 60 Antibodies
ELISA (Capture) 2 Antibodies
ELISA (Detection) 1 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 60 Antibodies
Functional Studies (Func) 8 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 9 Antibodies
Immunohistochemistry (IHC) 22 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 14 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 5 Antibodies
Immunoprecipitation (IP) 13 Antibodies
Intracellular Flow Cytometry (ICFC) 4 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Neutralization (Neut) 10 Antibodies
Western Blotting (WB) 48 Antibodies

General

Antigen Interleukin-6 Receptor (IL6R) Antibodies
Reactivity Human
(129), (58), (43)
Host Mouse
(86), (82), (23), (15), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL-6 Receptor antibody is conjugated to Alexa Fluor 647
(22), (14), (11), (10), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Mass Cytometry (CyTOF)
(86), (76), (72), (27), (22), (15), (12), (11), (11), (11), (10), (9), (8), (6), (4), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-IL-6 Receptor Antibody

Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2657623) Images
Purification The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
Clone BL-126
Isotype IgG1

Target Details IL-6 Receptor

Product Details anti-IL-6 Receptor Antibody Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2657623) Images back to top
Antigen
Alternative Name CD126 (IL6R Antibody Abstract)
Background CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α -chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. Soluble form of CD126 has been found in human serum.
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling References for anti-IL-6 Receptor Antibody (ABIN2657623) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details References for anti-IL-6 Receptor Antibody (ABIN2657623) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C

References for anti-IL-6 Receptor Antibody (ABIN2657623)

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling Images back to top
Background publications

Boulanger, Chow, Brevnova, Garcia: "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex." in: Science (New York, N.Y.), Vol. 300, Issue 5628, pp. 2101-4, 2003

Taga, Kishimoto: "Gp130 and the interleukin-6 family of cytokines." in: Annual review of immunology, Vol. 15, pp. 797-819, 1997

Gaillard, Bataille, Brailly, Zuber, Yasukawa, Attal, Maruo, Taga, Kishimoto, Klein: "Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy." in: European journal of immunology, Vol. 23, Issue 4, pp. 820-4, 1993

Images

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2657623) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-IL-6 Receptor antibody (Interleukin-6 Receptor)  (Alexa Fluor 647) (ABIN2657623) anti-Interleukin-6 Receptor (IL6R) antibody (Alexa Fluor 647)
Flow Cytometry (FACS) image for anti-IL-6 Receptor antibody (Interleukin-6 Receptor)  (Alexa Fluor 647) (ABIN2657623) anti-Interleukin-6 Receptor (IL6R) antibody (Alexa Fluor 647) (Image 2)