You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Rat (Rattus) IL-6 Receptor antibody for Flow Cytometry

Recommended IL-6 Receptor Antibody (supplied by: Log in to see )

Antigen
Interleukin-6 Receptor (IL6R) Antibodies
  • CD126
  • gp80
  • IL-6R
  • IL-6R-1
  • IL-6RA
  • il-6ra
  • IL-6Ralpha
  • IL6Q
  • Il6r
  • IL6R
  • IL6R1
  • IL6RA
  • Il6ra
  • IL6RQ
Reactivity
Mouse (Murine), Rat (Rattus)
154
66
43
1
Host
Rat
106
88
31
15
1
Clonality
Monoclonal
Conjugate
This IL-6 Receptor antibody is un-conjugated
22
14
12
10
5
4
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC)
101
101
81
43
38
27
27
24
18
13
11
10
8
6
4
2
2
2
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Catalog No. ABIN2665904
Contact our Customer Service for availability and price in your country.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0010482287 ABIN2665905 FACS IHC Rat IgG2b kappa Log in to see D7715A7 11

Top referenced anti-IL-6 Receptor antibody for Flow Cytometry

Similar anti-IL-6 Receptor Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 15 Antibodies 16 Antibodies
ELISA (Capture) 4 Antibodies 4 Antibodies
ELISpot (Capture) (ELISPOT (Capture)) 2 Antibodies 2 Antibodies
Flow Cytometry (FACS) 2 Antibodies 22 Antibodies
Immunocytochemistry (ICC) 6 Antibodies
Immunofluorescence (IF) 3 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 5 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 9 Antibodies
Intracellular Flow Cytometry (ICFC) 4 Antibodies
Neutralization (Neut) 2 Antibodies
Western Blotting (WB) 18 Antibodies
Blocking Reagent (BR) 1 Antibodies
Functional Studies (Func) 2 Antibodies
Immunochromatography (IC) 1 Antibodies

General

Antigen Interleukin-6 Receptor (IL6R) Antibodies
Reactivity Mouse (Murine), Rat (Rattus)
(154), (66), (43), (1)
Host Rat
(106), (88), (31), (15), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL-6 Receptor antibody is un-conjugated
(22), (14), (12), (10), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Immunohistochemistry (IHC)
(101), (101), (81), (43), (38), (27), (27), (24), (18), (13), (11), (10), (8), (6), (4), (2), (2), (2), (1), (1), (1), (1)
Pubmed 11 references available
Supplier Log in to see

Product Details anti-IL-6 Receptor Antibody

Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2665904) Images
Brand LEAF™
Purification The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level

Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.

Clone D7715A7
Isotype IgG2b kappa

Target Details IL-6 Receptor

Product Details anti-IL-6 Receptor Antibody Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2665904) Images back to top
Antigen
Alternative Name CD126 (IL6R Antibody Abstract)
Background CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. The D7715A7 (15A7) antibody blocks IL-6/IL-6 receptor interactions.
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling References for anti-IL-6 Receptor Antibody (ABIN2665904) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details References for anti-IL-6 Receptor Antibody (ABIN2665904) Images back to top
Concentration 1.0 mg/mL
Preservative Azide free
Handling Advice This LEAF™ solution contains no preservative, handle under aseptic conditions.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL-6 Receptor Antibody (ABIN2665904)

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling Images back to top
Background publications

Sintes, Romero, de Salort, Terhorst, Engel: "Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages." in: Journal of leukocyte biology, Vol. 88, Issue 4, pp. 687-97, 2010

Walker, Zhang, Matthews, Weinstock, Nice, Ernst, Rose-John, Burgess: "IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice." in: Blood, Vol. 111, Issue 8, pp. 3978-85, 2008

Yadav, Rosenbaum, Goetzl: "Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 2772-6, 2008

Koizumi, Yamaguchi, Kawabata, Sakurai, Sasaki, Watanabe, Hayakawa, Mizuguchi: "Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 3, pp. 1767-73, 2007

Weigert, Hennige, Lehmann, Brodbeck, Baumgartner, Schaüble, Häring, Schleicher: "Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells." in: The Journal of biological chemistry, Vol. 281, Issue 11, pp. 7060-7, 2006

Sun, Tian, Kulkarni, Gao: "IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 9, pp. 5648-55, 2004

Boulanger, Chow, Brevnova, Garcia: "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex." in: Science (New York, N.Y.), Vol. 300, Issue 5628, pp. 2101-4, 2003

McKinney, Jaskot, Richards, Costa, Dreher: "Cytokine mediation of ozone-induced pulmonary adaptation." in: American journal of respiratory cell and molecular biology, Vol. 18, Issue 5, pp. 696-705, 1998

Taga, Kishimoto: "Gp130 and the interleukin-6 family of cytokines." in: Annual review of immunology, Vol. 15, pp. 797-819, 1997

Coulie, Vink, Van Snick: "A monoclonal antibody specific for the murine IL-6-receptor inhibits the growth of a mouse plasmacytoma in vivo." in: Current topics in microbiology and immunology, Vol. 166, pp. 43-6, 1991

Vink, Coulie, Warnier, Renauld, Stevens, Donckers, Van Snick: "Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor." in: The Journal of experimental medicine, Vol. 172, Issue 3, pp. 997-1000, 1990