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anti-Rat (Rattus) IL-6 Receptor antibody for Immunohistochemistry

Recommended IL-6 Receptor Antibody (supplied by: Log in to see )

Antigen
Interleukin-6 Receptor (IL6R) Antibodies
  • CD126
  • gp80
  • IL-6R
  • IL-6R-1
  • IL-6RA
  • il-6ra
  • IL-6Ralpha
  • IL6Q
  • Il6r
  • IL6R
  • IL6R1
  • IL6RA
  • Il6ra
  • IL6RQ
Reactivity
Mouse (Murine), Rat (Rattus)
154
66
43
1
Host
Rat
106
88
31
15
1
Clonality
Monoclonal
Conjugate
This IL-6 Receptor antibody is conjugated to Biotin
21
14
12
10
5
4
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA (Capture), ELISpot (Capture) (ELISPOT (Capture)), Intracellular Flow Cytometry (ICFC), Neutralization (Neut), Immunohistochemistry (IHC), Western Blotting (WB)
102
101
80
43
38
27
27
24
18
12
11
10
7
5
4
2
2
1
1
1
1
1
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Catalog No. ABIN2660934
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0011340706 ABIN2660933 ELISA (Capture) ELISPOT (Capture) ICFC Neut IHC WB Biotin Rat IgG2b kappa Log in to see D7715A7 11
0.0011340706 ABIN2665904 FACS IHC Rat IgG2b kappa Log in to see D7715A7 11
0.0011340706 ABIN2665905 FACS IHC Rat IgG2b kappa Log in to see D7715A7 11
0.0011340706 ABIN1175059 IHC ELISA WB Biotin Rabbit IgG Log in to see Polyclonal

Top referenced anti-IL-6 Receptor antibody for Immunohistochemistry

Similar anti-IL-6 Receptor Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 15 Antibodies 16 Antibodies
ELISA (Capture) 4 Antibodies 4 Antibodies
ELISpot (Capture) (ELISPOT (Capture)) 2 Antibodies 2 Antibodies
Flow Cytometry (FACS) 2 Antibodies 22 Antibodies
Immunocytochemistry (ICC) 6 Antibodies
Immunofluorescence (IF) 3 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 5 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 9 Antibodies
Intracellular Flow Cytometry (ICFC) 4 Antibodies
Neutralization (Neut) 2 Antibodies
Western Blotting (WB) 18 Antibodies
Blocking Reagent (BR) 1 Antibodies
Functional Studies (Func) 2 Antibodies
Immunochromatography (IC) 1 Antibodies

General

Antigen Interleukin-6 Receptor (IL6R) Antibodies
Reactivity Mouse (Murine), Rat (Rattus)
(154), (66), (43), (1)
Host Rat
(106), (88), (31), (15), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL-6 Receptor antibody is conjugated to Biotin
(21), (14), (12), (10), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA (Capture), ELISpot (Capture) (ELISPOT (Capture)), Intracellular Flow Cytometry (ICFC), Neutralization (Neut), Immunohistochemistry (IHC), Western Blotting (WB)
(102), (101), (80), (43), (38), (27), (27), (24), (18), (12), (11), (10), (7), (5), (4), (2), (2), (1), (1), (1), (1), (1)
Pubmed 11 references available
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Product Details anti-IL-6 Receptor Antibody

Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2660934) Images
Purification The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Clone D7715A7
Isotype IgG2b kappa

Target Details IL-6 Receptor

Product Details anti-IL-6 Receptor Antibody Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2660934) Images back to top
Antigen
Alternative Name CD126 (IL6R Antibody Abstract)
Background CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. The D7715A7 (15A7) antibody blocks IL-6/IL-6 receptor interactions.
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling References for anti-IL-6 Receptor Antibody (ABIN2660934) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details References for anti-IL-6 Receptor Antibody (ABIN2660934) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL-6 Receptor Antibody (ABIN2660934)

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling Images back to top
Background publications

Sintes, Romero, de Salort, Terhorst, Engel: "Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages." in: Journal of leukocyte biology, Vol. 88, Issue 4, pp. 687-97, 2010

Walker, Zhang, Matthews, Weinstock, Nice, Ernst, Rose-John, Burgess: "IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice." in: Blood, Vol. 111, Issue 8, pp. 3978-85, 2008

Yadav, Rosenbaum, Goetzl: "Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 2772-6, 2008

Koizumi, Yamaguchi, Kawabata, Sakurai, Sasaki, Watanabe, Hayakawa, Mizuguchi: "Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 3, pp. 1767-73, 2007

Weigert, Hennige, Lehmann, Brodbeck, Baumgartner, Schaüble, Häring, Schleicher: "Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells." in: The Journal of biological chemistry, Vol. 281, Issue 11, pp. 7060-7, 2006

Sun, Tian, Kulkarni, Gao: "IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 9, pp. 5648-55, 2004

Boulanger, Chow, Brevnova, Garcia: "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex." in: Science (New York, N.Y.), Vol. 300, Issue 5628, pp. 2101-4, 2003

McKinney, Jaskot, Richards, Costa, Dreher: "Cytokine mediation of ozone-induced pulmonary adaptation." in: American journal of respiratory cell and molecular biology, Vol. 18, Issue 5, pp. 696-705, 1998

Taga, Kishimoto: "Gp130 and the interleukin-6 family of cytokines." in: Annual review of immunology, Vol. 15, pp. 797-819, 1997

Coulie, Vink, Van Snick: "A monoclonal antibody specific for the murine IL-6-receptor inhibits the growth of a mouse plasmacytoma in vivo." in: Current topics in microbiology and immunology, Vol. 166, pp. 43-6, 1991

Vink, Coulie, Warnier, Renauld, Stevens, Donckers, Van Snick: "Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor." in: The Journal of experimental medicine, Vol. 172, Issue 3, pp. 997-1000, 1990

Images

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2660934) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-IL-6 Receptor antibody (Interleukin-6 Receptor)  (Biotin) (ABIN2660934) anti-Interleukin-6 Receptor (IL6R) antibody (Biotin)