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this study shows that recombinant IL-11 is effective with tolerable adverse effects in Chinese patients with autoimmune thrombocytopenic purpura
HMGA2 promoted colorectal cancer metastasis and epithelial-mesenchymal transition via activation of the FN1 (show FN1 Proteins) and IL11/STAT3 (show STAT3 Proteins) signaling pathways.
Together, these results suggest that the IL-11/STAT3 (show STAT3 Proteins) signaling pathway plays a critical role in human chronic atrophic gastritis , and may provide new targets to prevent and treat gastric cancer
Proteolysis of the IL-11R represents a molecular switch that controls the IL-11 trans-signaling pathway which is the target in intestinal tumorigenesis, lung carcinomas, and asthma.
IL-11 has a protective role and can accelerate recovery of platelets, and remarkably lessen the extent of inflammatory responses, hence reducing the mortality in sepsis patients accompanied with thrombocytopenia.
Results indicate that iterleukin-11 (IL11) is causal of Preeclampsia (PE) features in a mouse model and likely in women, and suggest potential of IL11 inhibition to rescue PE symptoms in women.
The cross-talk between Th17 and interleukin 11 (IL-11+)CD4 (show CD4 Proteins)+ T cells may induce and amplify the autoimmune response in the early stage of multiple sclerosis (MS), and thus represent an attractive therapeutic target in this and other inflammatory diseases.
Genetic variations of IL-11 may be associated with the risk of Hirschsprung disease and/or the mechanisms related to enteric nervous system development.
IL-11 expression in breast cancer correlates with poor disease outcome
data offer insight into the binding interactions of IL-11 with each of its receptors and the structural mechanisms underlying agonist and antagonist variants of the protein
IL-11-mediated STAT3 (show STAT3 Proteins) signaling not only reduces hepatocellular apoptosis, but also inhibits inflammatory responses.
IL-1 (show IL1A Proteins) signaling antagonizes IL-11/STAT3 (show STAT3 Proteins) mediated pathology and the genetic deletion of IL-1RT1 results in increased tumor burden.
PGF2alpha inhibits adipocyte differentiation by means of an IL-11 mediated autocrine negative feedback loop, that acts via gp130 (show LRPPRC Proteins) to block adipogenesis through the essential actions of the STAT1 (show STAT1 Proteins) transcription factor.
Data indicate that colonic inflammation was more severe in mice fed an iron-supplemented compared with a control diet one week post-DSS (show PMP22 Proteins) treatment, with enhanced colonic IL-6 (show IL6 Proteins) and IL-11 release and Stat3 (show STAT3 Proteins) phosphorylation.
IL-11 reduced the production of reactive oxygen species.
IL-11 therefore drives a pathway that enhances HSPC (show PSMA7 Proteins) radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk (show SH2B3 Proteins).
IL-11 signaling may not play as significant a role in spinal cord injury as other glycoprotein gp130 cytokines.
Data support the view that IL-11 is a key regulator of gastric damage acting to initiate chronic atrophic gastritis.
Bovine lactoferrin (show LTF Proteins) administration prevented the progression of hepatic failure in human myofibroblasts and mice, and enhanced IL-11 and BMP2 (show BMP2 Proteins) expression in the small intestine.
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, adipogenesis inhibitory factor