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Human IL11 Protein expressed in Escherichia coli (E. coli) - ABIN2667453
Barton, Hall, Hudson, Heath: Interleukin-11 signals through the formation of a hexameric receptor complex. in The Journal of biological chemistry 2000
Show all 7 references for ABIN2667453
Mouse (Murine) IL11 Protein expressed in HEK-293 - ABIN2666950
Chen, Rabach, Noble, Zheng, Lee, Homer, Elias: IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. in Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 7 references for ABIN2666950
Human IL11 Protein expressed in HEK-293 - ABIN2666948
Elias, Zheng, Einarsson, Landry, Trow, Rebert, Panuska: Epithelial interleukin-11. Regulation by cytokines, respiratory syncytial virus, and retinoic acid. in The Journal of biological chemistry 1994
Show all 7 references for ABIN2666948
Proteolysis of the IL-11R represents a molecular switch that controls the IL-11 trans-signaling pathway which is the target in intestinal tumorigenesis, lung carcinomas, and asthma.
IL-11 has a protective role and can accelerate recovery of platelets, and remarkably lessen the extent of inflammatory responses, hence reducing the mortality in sepsis patients accompanied with thrombocytopenia.
Results indicate that iterleukin-11 (IL11) is causal of Preeclampsia (PE) features in a mouse model and likely in women, and suggest potential of IL11 inhibition to rescue PE symptoms in women.
The cross-talk between Th17 and interleukin 11 (IL-11+)CD4 (show CD4 Proteins)+ T cells may induce and amplify the autoimmune response in the early stage of multiple sclerosis (MS), and thus represent an attractive therapeutic target in this and other inflammatory diseases.
Genetic variations of IL-11 may be associated with the risk of Hirschsprung disease and/or the mechanisms related to enteric nervous system development.
IL-11 expression in breast cancer correlates with poor disease outcome
data offer insight into the binding interactions of IL-11 with each of its receptors and the structural mechanisms underlying agonist and antagonist variants of the protein
The highly specific IL-11 - S100P (show S100P Proteins) interaction occurring under physiologically relevant conditions should be taken into consideration upon development of the antineoplastics inhibiting IL-11 signaling.
MTA2 (show MTA2 Proteins) overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 is one of the downstream effectors of MTA2 (show MTA2 Proteins) in regulating gastric cancer cells growth
IL-11 stimulates BSP (show KLK6 Proteins) gene transcription.
IL-11-mediated STAT3 (show STAT3 Proteins) signaling not only reduces hepatocellular apoptosis, but also inhibits inflammatory responses.
IL-1 (show IL1A Proteins) signaling antagonizes IL-11/STAT3 (show STAT3 Proteins) mediated pathology and the genetic deletion of IL-1RT1 results in increased tumor burden.
PGF2alpha inhibits adipocyte differentiation by means of an IL-11 mediated autocrine negative feedback loop, that acts via gp130 (show LRPPRC Proteins) to block adipogenesis through the essential actions of the STAT1 (show STAT1 Proteins) transcription factor.
Data indicate that colonic inflammation was more severe in mice fed an iron-supplemented compared with a control diet one week post-DSS (show PMP22 Proteins) treatment, with enhanced colonic IL-6 (show IL6 Proteins) and IL-11 release and Stat3 (show STAT3 Proteins) phosphorylation.
IL-11 reduced the production of reactive oxygen species.
IL-11 therefore drives a pathway that enhances HSPC (show PSMA7 Proteins) radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk (show SH2B3 Proteins).
IL-11 signaling may not play as significant a role in spinal cord injury as other glycoprotein gp130 (show LRPPRC Proteins) cytokines.
Data support the view that IL-11 is a key regulator of gastric damage acting to initiate chronic atrophic gastritis.
Bovine lactoferrin (show LTF Proteins) administration prevented the progression of hepatic failure in human myofibroblasts and mice, and enhanced IL-11 and BMP2 (show BMP2 Proteins) expression in the small intestine.
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, adipogenesis inhibitory factor