IL-11 Protein (AA 22-199) (Fc Tag)

Catalog No. ABIN7320821

This Recombinant IL-11 protein is produced in HEK-293 Cells.

Quick Overview for IL-11 Protein (AA 22-199) (Fc Tag) (ABIN7320821)

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 22-199

Purification tag / Conjugate: This IL-11 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse Interleukin-11/IL-11 Protein (Fc Tag)

Sequence: Pro22-Leu199

Characteristics: Recombinant Mouse Interleukin-11 is produced by our Mammalian expression system and the target gene encoding Pro22-Leu199 is expressed with a Fc tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 10 mM HAc-NaAc, 150 mM NaCl, 0.004 % Tween 80, 5 % Mannitol, pH 4.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Alternative Name: Interleukin-11/IL-11

Background: Interleukin,IL-11,Interleukin-11,Zcyto1,Zcyto10,Il11,AGIF,interleukin 11,Interleukin-11(IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cellproliferation and differentiation and could be use as a therapeutic for osteoporosis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. In addition to having lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many other tissues, including the brain, gut, testis and bone.

Molecular Weight:

Calculated MW: 46.3 kDa

Observed MW: 50-60 kDa

UniProt: P47873

Pathways: JAK-STAT Signaling, Negative Regulation of Hormone Secretion