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anti-Mouse (Murine) IL2 Receptor beta antibody for Blocking Reagent

Recommended IL2 Receptor beta Antibody (supplied by: Log in to see )

Antigen
Interleukin 2 Receptor, beta (IL2RB) Antibodies
  • CD122
  • Il-2/15Rbeta
  • il-2rb
  • Il-2Rbeta
  • IL-15Rbeta
  • IL2RB
  • IL2RBC
  • IL15RB
  • IL15Rbeta
  • p70
  • P70-75
Reactivity
Chemical, Mouse (Murine)
186
135
77
28
6
1
Host
Rat
118
110
62
Clonality
Monoclonal
Conjugate
This IL2 Receptor beta antibody is conjugated to Biotin
36
30
22
11
5
4
4
3
3
2
2
2
2
2
2
2
2
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS), Immunohistochemistry (IHC)
174
90
51
46
26
22
12
11
9
6
2
2
2
2
2
1
1
Supplier
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Catalog No. ABIN2660928
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008676689 ABIN1177313 BR FACS IP Rat IgG2b, kappa Log in to see TM-beta 1 18
0.0008676689 ABIN2660927 BR FACS IHC Biotin Rat IgG2a kappa Log in to see 5H4 4

Top referenced anti-IL2 Receptor beta antibody for Blocking Reagent

Similar anti-IL2 Receptor beta Antibodies

Application / Reactivity Mouse (Murine) Chemical
Blocking Reagent (BR) 3 Antibodies 2 Antibodies
ELISA 28 Antibodies
Flow Cytometry (FACS) 123 Antibodies 29 Antibodies
Functional Studies (Func) 6 Antibodies
Immunocytochemistry (ICC) 3 Antibodies 2 Antibodies
Immunofluorescence (IF) 8 Antibodies 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 22 Antibodies
Immunohistochemistry (IHC) 17 Antibodies 5 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 10 Antibodies
Immunoprecipitation (IP) 50 Antibodies
Mass Cytometry (CyTOF) 2 Antibodies
Neutralization (Neut) 1 Antibodies
Western Blotting (WB) 47 Antibodies

General

Antigen Interleukin 2 Receptor, beta (IL2RB) Antibodies
Reactivity Chemical, Mouse (Murine)
(186), (135), (77), (28), (6), (1)
Host Rat
(118), (110), (62)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL2 Receptor beta antibody is conjugated to Biotin
(36), (30), (22), (11), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Blocking Reagent (BR), Flow Cytometry (FACS), Immunohistochemistry (IHC)
(174), (90), (51), (46), (26), (22), (12), (11), (9), (6), (2), (2), (2), (2), (2), (1), (1)
Pubmed 4 references available
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Product Details anti-IL2 Receptor beta Antibody

Target Details IL2 Receptor beta Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2660928) Images
Purification The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Clone 5H4
Isotype IgG2a kappa

Target Details IL2 Receptor beta

Product Details anti-IL2 Receptor beta Antibody Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2660928) Images back to top
Antigen
Alternative Name CD122 (IL2RB Antibody Abstract)
Target Type Chemical
Background CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit(CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Handling References for anti-IL2 Receptor beta Antibody (ABIN2660928) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details References for anti-IL2 Receptor beta Antibody (ABIN2660928) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL2 Receptor beta Antibody (ABIN2660928)

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details Handling Images back to top
Background publications

Suzuki, Kündig, Furlonger, Wakeham, Timms, Matsuyama, Schmits, Simard, Ohashi, Griesser: "Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta." in: Science (New York, N.Y.), Vol. 268, Issue 5216, pp. 1472-6, 1995

He, Adkins, Furse, Malek: "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1596-605, 1995

Furse, Malek et al.: "Selection of internalization-deficient cells by interleukin-2-Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin-2 receptor beta chain does not contribute to ..." in: European journal of immunology, Vol. 23, Issue 12, pp. 3181-8, 1994

Minami, Kono, Miyazaki, Taniguchi: "The IL-2 receptor complex: its structure, function, and target genes." in: Annual review of immunology, Vol. 11, pp. 245-68, 1993

Images

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2660928) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-IL2 Receptor beta antibody (Interleukin 2 Receptor, beta)  (Biotin) (ABIN2660928) anti-Interleukin 2 Receptor, beta (IL2RB) antibody (Biotin)