This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
IL21
Origin: Human
Host: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ELISA
IL21
Origin: Human
Host: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
IL21
Origin: Human
Host: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Yoon, Zhang, Berner, Blom, Choi: "Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 1, pp. 352-8, (2009) (PubMed).
Yoon, Zhang, Berner, Choi: "IL-21 and IL-10 have redundant roles but differential capacities at different stages of Plasma Cell generation from human Germinal Center B cells." in: Journal of leukocyte biology, Vol. 86, Issue 6, pp. 1311-8, (2009) (PubMed).