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This study demonistrated that loss of htr5A gene strongly upregulates 5-HT1A receptor (show CC2D1A Proteins)-mediated currents in the prefrontal cortex.
Results suggest that TPH1 (show TPH1 Proteins) 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression
Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders.
Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels
Association of a SNP of HTR5A gene is a susceptibility factor to bipolar disease in Bulgarian population.
N-glycosylation of the N6 residue is important for the membrane expression of this 5-HT5A neurotransmitter receptor (show GRIN1 Proteins); a requirement for receptor function.
The receptor has been transiently expressed in Cos M6 cells and exhibits a pharmacological profile closely resembling the mouse and rat 5-HT5A receptors with high, specific binding for ergotamine and methiothepin.
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization.
5-hydroxytryptamine (serotonin) receptor 5A
, 5-hydroxytryptamine receptor 5A
, 5-hydroxytryptamine receptor 5A-like
, serotonin receptor 5A