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|Antigen||Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Antibodies|
|Reactivity||Dog (Canine), Human Alternatives|
|Conjugate||This STAT6 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
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Product Details anti-STAT6 AntibodyTarget Details STAT6 Application Details Handling Images
|Specificity||This antibody specifically recognizes STAT6 at 100 kDa.|
|Characteristics||Synonyms: STAT-6, IL-4 Stat, IL-4-STAT, Signal transducer and activator of transcription 6|
|Purification||Size Exclusion Chromatography|
|Components||incl. positive Control|
|Immunogen||Synthetic peptide conjuagted to KLH|
Target Details STAT6Product Details anti-STAT6 Antibody Application Details Handling Images back to top
|Alternative Name||STAT6 (STAT6 Antibody Abstract)|
|Background||The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STATs are mediators involved in cytokine signalling. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their SH2 domains and move to the nucleus. The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT6 is activated primarily by IL-4 and IL-13. Upon activation, STAT6 is phosphorylated at tyrosine 641 by Janus Kinase (JAK). Phosphorylated STAT6 forms head-to-tail heterodimers and translocates to the nucleus where it paricipates in transcriptional control.Synonyms: IL-4 Stat, Signal transducer and activator of transcription 6|
|Research Area||Chromatin and Nuclear Signaling, Signaling, Receptors, Inflammation|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response|
Application DetailsProduct Details anti-STAT6 Antibody Target Details STAT6 Handling Images back to top
Western Blot: 1 μg/mL for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubationbuffer. ELISA: 0.05 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT6 Antibody Target Details STAT6 Application Details Images back to top
|Reconstitution||Restore with 1 mL H2O (15 min, RT).|
|Buffer||1 mL2 x PBS / 0.09 % Sodium Azide / PEG and Sucrose|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||-20 °C/-80 °C|
Store lyophilized (preferably in a desiccator) at -20 °C and reconstituted (aliquote andfreeze in liquid nitrogen) at -80 °C. Avoid repeated freezing and thawing. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 4 °C up to 3 months.
Shelf life: one year from despatch.
|Expiry Date||12 months|
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