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anti-Mouse (Murine) STAT6 antibody for Biochemical Assay

Recommended STAT6 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Antibodies
  • D12S1644
  • IL-4-STAT
  • STAT6B
  • STAT6C
Reactivity
Human, Mouse (Murine)
293
113
97
12
8
7
6
4
2
Host
Mouse
248
72
3
1
Clonality
Monoclonal
Conjugate
This STAT6 antibody is un-conjugated
10
9
8
7
5
5
5
3
3
3
3
3
3
3
2
1
1
Application
Biochemical Assay (BCA)
222
107
83
38
33
33
32
18
15
12
6
4
1
1
1
Supplier
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Catalog No. ABIN2666296
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Top referenced anti-STAT6 antibody for Biochemical Assay

Similar anti-STAT6 Antibodies

Application / Reactivity Human Mouse (Murine)
Western Blotting (WB) 210 Antibodies 70 Antibodies
Intracellular Staining (ICS) 12 Antibodies 9 Antibodies
Immunoprecipitation (IP) 33 Antibodies 14 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 35 Antibodies 19 Antibodies
Immunohistochemistry (IHC) 109 Antibodies 29 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 4 Antibodies 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 33 Antibodies 22 Antibodies
Immunofluorescence (IF) 33 Antibodies 9 Antibodies
Immunocytochemistry (ICC) 10 Antibodies 3 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunoassay (IA) 1 Antibodies

General

Antigen Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Antibodies
Reactivity Human, Mouse (Murine)
(293), (113), (97), (12), (8), (7), (6), (4), (2)
Host Mouse
(248), (72), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This STAT6 antibody is un-conjugated
(10), (9), (8), (7), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1)
Application Biochemical Assay (BCA)
(222), (107), (83), (38), (33), (33), (32), (18), (15), (12), (6), (4), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-STAT6 Antibody

Target Details STAT6 Application Details Handling References for anti-STAT6 Antibody (ABIN2666296) Images
Purification Affinity purified.
Clone 16G12A08
Isotype IgG1 kappa

Target Details STAT6

Product Details anti-STAT6 Antibody Application Details Handling References for anti-STAT6 Antibody (ABIN2666296) Images back to top
Antigen
Alternative Name STAT6 (STAT6 Antibody Abstract)
Background STAT6 is a member of the signal transducer and activator of transcription (STAT) family, activating gene expression in response to IL-4 and IL-13 stimulation. Upon cytokine stimulation, the receptor is phosphorylated by the associated Janus Kinases (Jak), followed by recruiting cytoplasmic STAT6. The Y641 residue of STAT6 is, in turn, phosphorylated by Jak. Phosphorylated STAT6 forms homodimers, transclocates to the nucleus, and regulates transcription of target genes. STAT6 plays crucial roles in differentiation of T helper 2 (Th2) cells, class switch of immunoglobulins in B cells, expression of cell surface markers such as MHC class II, and the development of allergic inflammation.
Research Area Chromatin and Nuclear Signaling, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling

Application Details

Product Details anti-STAT6 Antibody Target Details STAT6 Handling References for anti-STAT6 Antibody (ABIN2666296) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details References for anti-STAT6 Antibody (ABIN2666296) Images back to top
Concentration 0.5 mg/mL
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store undiluted between 2°C and 8°C.

References for anti-STAT6 Antibody (ABIN2666296)

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details Handling Images back to top
Background publications

Goenka, Kaplan: "Transcriptional regulation by STAT6." in: Immunologic research, Vol. 50, Issue 1, pp. 87-96, 2011

Zamorano, Rivas, Setien, Perez-G: "Proteolytic regulation of activated STAT6 by calpains." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 5, pp. 2843-8, 2005

David, Ford, Bertoglio, Maizel, Pierre: "Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways." in: Oncogene, Vol. 20, Issue 46, pp. 6660-8, 2001

Wurster, Tanaka, Grusby: "The biology of Stat4 and Stat6." in: Oncogene, Vol. 19, Issue 21, pp. 2577-84, 2000

Akira: "Functional roles of STAT family proteins: lessons from knockout mice." in: Stem cells (Dayton, Ohio), Vol. 17, Issue 3, pp. 138-46, 1999

Takeda, Tanaka, Shi, Matsumoto, Minami, Kashiwamura, Nakanishi, Yoshida, Kishimoto, Akira: "Essential role of Stat6 in IL-4 signalling." in: Nature, Vol. 380, Issue 6575, pp. 627-30, 1996

Images

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details Handling References for anti-STAT6 Antibody (ABIN2666296) back to top
Supplier Images
Immunofluorescence (IF) image for anti-STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (ABIN2666296) anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) antibody
Western Blotting (WB) image for anti-STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (ABIN2666296) anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) antibody (Image 2)