|Application / Reactivity||Human||Mouse (Murine)|
|Western Blotting (WB)||210 Antibodies||70 Antibodies|
|Intracellular Staining (ICS)||12 Antibodies||9 Antibodies|
|Immunoprecipitation (IP)||33 Antibodies||14 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||35 Antibodies||19 Antibodies|
|Immunohistochemistry (IHC)||109 Antibodies||29 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||33 Antibodies||22 Antibodies|
|Immunofluorescence (IF)||33 Antibodies||9 Antibodies|
|Immunocytochemistry (ICC)||10 Antibodies||3 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunoassay (IA)||1 Antibodies|
|Antigen||Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This STAT6 antibody is un-conjugated Alternatives|
Biochemical Assay (BCA)
|6 references available|
|Supplier||Log in to see|
Product Details anti-STAT6 AntibodyTarget Details STAT6 Application Details Handling References for anti-STAT6 Antibody (ABIN2666296) Images
Target Details STAT6Product Details anti-STAT6 Antibody Application Details Handling References for anti-STAT6 Antibody (ABIN2666296) Images back to top
|Alternative Name||STAT6 (STAT6 Antibody Abstract)|
|Background||STAT6 is a member of the signal transducer and activator of transcription (STAT) family, activating gene expression in response to IL-4 and IL-13 stimulation. Upon cytokine stimulation, the receptor is phosphorylated by the associated Janus Kinases (Jak), followed by recruiting cytoplasmic STAT6. The Y641 residue of STAT6 is, in turn, phosphorylated by Jak. Phosphorylated STAT6 forms homodimers, transclocates to the nucleus, and regulates transcription of target genes. STAT6 plays crucial roles in differentiation of T helper 2 (Th2) cells, class switch of immunoglobulins in B cells, expression of cell surface markers such as MHC class II, and the development of allergic inflammation.|
|Research Area||Chromatin and Nuclear Signaling, Signaling, Receptors, Inflammation|
Application DetailsProduct Details anti-STAT6 Antibody Target Details STAT6 Handling References for anti-STAT6 Antibody (ABIN2666296) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT6 Antibody Target Details STAT6 Application Details References for anti-STAT6 Antibody (ABIN2666296) Images back to top
|Buffer||phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Upon receipt, store undiluted between 2°C and 8°C.|
References for anti-STAT6 Antibody (ABIN2666296)Product Details anti-STAT6 Antibody Target Details STAT6 Application Details Handling Images back to top
Goenka, Kaplan: "Transcriptional regulation by STAT6." in: Immunologic research, Vol. 50, Issue 1, pp. 87-96, 2011 (PubMed).
Zamorano, Rivas, Setien et al.: "Proteolytic regulation of activated STAT6 by calpains." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 5, pp. 2843-8, 2005 (PubMed).
David, Ford, Bertoglio et al.: "Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways." in: Oncogene, Vol. 20, Issue 46, pp. 6660-8, 2001 (PubMed).
Wurster, Tanaka, Grusby: "The biology of Stat4 and Stat6." in: Oncogene, Vol. 19, Issue 21, pp. 2577-84, 2000 (PubMed).
Akira: "Functional roles of STAT family proteins: lessons from knockout mice." in: Stem cells (Dayton, Ohio), Vol. 17, Issue 3, pp. 138-46, 1999 (PubMed).
Takeda, Tanaka, Shi et al.: "Essential role of Stat6 in IL-4 signalling." in: Nature, Vol. 380, Issue 6575, pp. 627-30, 1996 (PubMed).
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