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Browse our Dystroglycan Proteins (DAG1)

Full name:
Dystroglycan 1 Proteins (DAG1)
On www.antibodies-online.com are 11 Dystroglycan 1 (DAG1) Proteins from 4 different suppliers available. Additionally we are shipping Dystroglycan Antibodies (98) and Dystroglycan Kits (13) and many more products for this protein. A total of 129 Dystroglycan products are currently listed.
Synonyms:
156DAG, A3a, AGRNR, D9Wsu13e, DAG, DG, Dp71, Dp427, MDDGC7, MDDGC9, RAB7
list all proteins Gene Name GeneID UniProt
DAG1 13138 Q62165
DAG1 1605 Q14118
Rat DAG1 DAG1 114489  

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Dystroglycan Proteins (DAG1) by Origin

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Top referenced Dystroglycan Proteins

  1. Human Dystroglycan Protein expressed in Wheat germ - ABIN1351078 : Hesse, Johansson, Mattsson, Bremell, Andreasson, Halim, Anckarsäter, Blennow, Anckarsäter, Zetterberg, Larson, Hagberg, Grahn: The N-terminal domain of ?-dystroglycan, released as a 38 kDa protein, is increased in cerebrospinal fluid in patients with Lyme neuroborreliosis. in Biochemical and biophysical research communications 2011 (PubMed)

More Proteins for Dystroglycan Interaction Partners

Mouse (Murine) Dystroglycan 1 (DAG1) interaction partners

  1. Fktn (show FKTN Proteins) deficient mice express moderate to severe muscular dystrophy; glycosylated alpha-dystroglycan has a unique role in muscle regeneration in these mice

  2. 5-amino-4-imidazolecarboxamide riboside treatment increases utrophin A and beta-dystroglycan expression in mdx (show DMD Proteins) mouse muscle.

  3. Phosphorylation within the cysteine-rich region of dystrophin (show DMD Proteins) enhances its association with beta-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting.

  4. Results suggest that by interfering in the cross-talk between the transmembrane form of the laminin receptor dystroglycan and F-actin, AHNAK1 (show AHNAK Proteins) influences the cytoskeleton organization of Schwann cells

  5. We evaluate the key characteristics of the mdx in comparison with other mouse mutants with inactivations in DAPC components, along with key modifiers of the disease phenotype.

  6. results indicate a novel role for laminin-dystroglycan interactions in the cooperative integration of astrocytes, endothelial cells, and pericytes in regulating the Blood Brain Barrier.

  7. Endogenous glucuronyltransferase activity of LARGE or LARGE2 (show GYLTL1B Proteins) required for functional modification of alpha-dystroglycan in cells and tissues.

  8. Beta-dystroglycan can respond to ezrin (show EZR Proteins) driven cytoskeletal and cell morphology changes,by translocating from the cytoplasm to the nucleus.

  9. Alpha dystroglycan is a perlecan (show HSPG2 Proteins) receptor that specifically functions in the stellate reticulum of the embryonic stage.

  10. The study provides evidence for at least three separate pools of dystroglycan complexes within myofibers that differ in composition and are differentially affected by loss of dystrophin (show DMD Proteins).

Human Dystroglycan 1 (DAG1) interaction partners

  1. The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol beta1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan.

  2. Data show that CD93 antigen proved to be phosphorylated on tyrosine 628 and 644 following cell adhesion on laminin through dystroglycan.

  3. Phosphorylation within the cysteine-rich region of dystrophin (show DMD Proteins) enhances its association with beta-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting.

  4. Novel mutations in DAG1 are associated with asymptomatic hyperCKemia with hypoglycosylation of alpha-dystroglycan.

  5. Depletion of DAG resulted in altered morphology and reduced properties of differentiated HL-60 cells, including chemotaxis, respiratory burst, phagocytic activities and markers of differentiation, implicating DAG as a protein involved in differentiation.

  6. A report of a homozygous novel DAG1 missense mutation c.2006G>T in the beta-subunit of dystroglycan in two Libyan siblings with with a novel muscle-eye-brain disease-like phenotype with multicystic leucodystrophy.

  7. The study provides evidence for at least three separate pools of dystroglycan complexes within myofibers that differ in composition and are differentially affected by loss of dystrophin (show DMD Proteins).

  8. These data suggest that proteolysis, tyrosine phosphorylation and translocation of dystroglycan to the nucleus resulting in altered gene transcription could be important mechanisms in the progression of prostate cancer.

  9. T192M point-mutation in dystroglycan leads to a weaker interactions with laminin-1 (show LAMA1 Proteins), which leads to hypoglycosylation and which finally leads to the limb girdle disease.

  10. GTDC2 (show GTDC2 Proteins) generates CTD110.6 antibody-reactive N-acetylglucosamine epitopes on the O-mannosylated alpha-dystroglycan.

Rabbit Dystroglycan 1 (DAG1) interaction partners

  1. Results provide evidence that MMP-2 (show MMP2 Proteins) bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.

Dystroglycan (DAG1) Protein Profile

Protein Summary

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

Alternative names and synonyms associated with Dystroglycan (DAG1)

  • dystroglycan 1 (Dag1)
  • dystroglycan 1 (dystrophin-associated glycoprotein 1) (DAG1)
  • dystroglycan 1 (dystrophin-associated glycoprotein 1) (Dag1)
  • dystroglycan-like (LOC100620392)
  • 156DAG protein
  • A3a protein
  • AGRNR protein
  • D9Wsu13e protein
  • DAG protein
  • DG protein
  • Dp71 protein
  • Dp427 protein
  • MDDGC7 protein
  • MDDGC9 protein
  • RAB7 protein

Protein level used designations for Dystroglycan 1 Proteins (DAG1)

alpha-dystroglycan , beta-dystroglycan , dystroglycan , dystrophin associated glycoprotein 1 , dystrophin-associated glycoprotein 1 , glycine cleavage system T-protein , RAB7, member RAS oncogene family

GENE ID SPECIES
13138 Mus musculus
100049058 Gallus gallus
1605 Homo sapiens
101103515 Ovis aries
114489 Rattus norvegicus
476623 Canis lupus familiaris
281439 Bos taurus
100734382 Cavia porcellus
100009278 Oryctolagus cuniculus
100620392 Sus scrofa
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