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kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E (show CENPE ELISA Kits) motor.
These data strongly indicated that KNTC2 is a promising target for the treatment of HCC (show FAM126A ELISA Kits) and that phosphorylated HH3 (show PROKR2 ELISA Kits) at serine 10 is one of the target engagement markers for KNTC2.
Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
Hec1-dependent cyclin B2 (show CCNB2 ELISA Kits) stabilization during early metaphase is important for early-stage spindle assembly.
Disruption of Ndc80 function by either siRNA injection or antibody injection resulted in severe chromosome misalignment, spindle disruption, and precocious polar body extrusion.
overexpression of Hec1 results in mitotic checkpoint (show BUB3 ELISA Kits) hyperactivation that leads to aneuploidy sufficient to generate tumors
Whereas CENP-C (show CENPC1 ELISA Kits) recruits a single MIS12 (show MIS12 ELISA Kits):NDC80 complex, the authors show here that CENP-T (show CENPT ELISA Kits) binds one MIS12 (show MIS12 ELISA Kits):NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1 (show CDK1 ELISA Kits):Cyclin B complex at three distinct CENP-T (show CENPT ELISA Kits) sites.
Ska is recruited to kinetochores by clusters of Ndc80 proteins.
Expression of NDC80 in colon cancer cells and tissues was higher than that in controls. NDC80 promotes the proliferation and metastasis of colon cancer cells.
Ndc80 complex bound to microtubules binds every tubulin (show TUBB ELISA Kits) monomer along the microtubule protofilament.
we conclude that Hec1 is consistently overexpressed in human PCa (show FLVCR1 ELISA Kits) and Hec1 is closely linked with human PCa (show FLVCR1 ELISA Kits) progression through the meditator LncRNA BX647187
Independent molecular binding events to microtubules (MTs (show TIMM8A ELISA Kits)) by individual NDC80 complexes, rather than their structured oligomers, regulate the dynamics and stability of kinetochore-MT attachments in dividing cells.
The Ndc80 complex binds straight microtubules by recognizing the dimeric interface of tubulin (show TUBB ELISA Kits).
Overproduction of Ndc80 in cancer cells may unfavourably absorb protein interactors through the internal loop domain and lead to a change in the equilibrium of microtubule-associated proteins. [Review]
N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics
Mechanisms of mitosis-specific assembly of the checkpoint platform Knl1 (show CASC5 ELISA Kits)/MIS12 (show MIS12 ELISA Kits)/NDC80 at human kinetochores.
mature attachment via the Ndc80 complex is essential for metaphase alignment and anaphase A
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.
kinetochore associated 2
, NDC80 homolog, kinetochore complex component (S. cerevisiae)
, NDC80 homolog, kinetochore complex component
, kinetochore protein NDC80 homolog
, kinetochore protein Ndc80
, Kinetochore protein NDC80 homolog
, highly expressed in cancer, rich in leucine heptad repeats
, kinetochore protein Hec1
, kinetochore-associated protein 2
, HEC (highly expressed in cancer)
, NDC80 kinetochore complex component homolog
, highly expressed in cancer protein
, retinoblastoma-associated protein HEC
, kinetochore spindle checkpoint protein Ndc80