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PEX5 (show PEX5 Proteins) binding to the PEX14N-terminal domain (PEX14N) has no effect on the affinity of PEX5 (show PEX5 Proteins) for a PTS1 containing peptides.
PEX14 facilitates peroxisomal matrix protein import in plants.
Data suggest that soluble/cytosolic PEX5 (show PEX5 Proteins) interacts with PEX14/PEX13 (show PEX13 Proteins) complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14/PEX13 (show PEX13 Proteins) complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 (show PEX5 Proteins) can enter to release its cargo. (PEX (show PHEX Proteins) = peroxisomal biogenesis factor)
data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 and PEX5 (show PEX5 Proteins) or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes.
PEX14 is the 13th PEX (show PHEX Proteins) gene responsible for peroxisome biogenesis disorders. Thus far, only two patients with PEX14 deficiency have been reported.
The novel Pex14-binding site may represent the initial tethering site of Pex5 (show PEX5 Proteins) from which the cargo-loaded receptor is further processed in a sequential manner.
interaction of PEX5 (show PEX5 Proteins) with catalase (show CAT Proteins) and PEX14
PEX14 is a multi-tasking protein that not only facilitates peroxisomal protein (show FNDC5 Proteins) import but is also required for peroxisome motility by serving as membrane anchor for microtubules.
peroxisomal localization of Pex14p is affected by Pex13p (show PEX13 Proteins)
a new complementation group of the peroxisome biogenesis disorders with PEX14 as the defective gene
This report represents the second PEX14-deficiency associated with Zellweger syndrome (show PEX1 Proteins) and the first documentation of a PEX14-deficient patient with detailed clinical follow-up and biochemical, morphological, and radiological data.
N-terminal domain of Pex14, Pex14(N), adopts a three-helical fold. Pex5 (show PEX5 Proteins) and Pex19 (show PEX19 Proteins) ligand helices bind competitively to the same surface in Pex14(N) albeit with opposite directionality.
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.
peroxisomal membrane protein PEX14
, NF-E2 associated polypeptide 2
, PTS1 receptor docking protein
, PTS1 receptor-docking protein
, peroxisomal membrane anchor protein PEX14
, peroxisomal membrane anchor protein Pex14p
, peroxisomal protein Pex14