Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

MAP3K4 Proteins

(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
MAP3K4 Protein (AA 1201-1300) (GST tag) MAP3K4 Protein (AA 1201-1300) (GST tag) MAP3K4 Protein (AA 1201-1300) (GST tag) (ABIN1310218)

MAP3K4 Origin: Human Host: Wheat germ Recombinant WB, AP, AA, ELISA

MAP3K4 Protein (ABIN2750508)

MAP3K4 Origin: Human, Mouse, Rat Host: Escherichia coli (E. coli) Recombinant WB, PC

MAP3K4 Proteins by Origin

Find MAP3K4 Proteins for a variety of species such as anti-Human MAP3K4, anti-Mouse MAP3K4, anti-Rat MAP3K4. The species listed below are among those available. Click on a link to go to the corresponding products.

MAP3K4 Proteins by Source

Here you will find MAP3K4 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

MAP3K4 Proteins by Protein Type

Here you can find MAP3K4 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

MAP3K4 Proteins by Application

Find MAP3K4 Proteins validated for a specific application such as WB, AP, AA, ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular MAP3K4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310218
Quantity 10 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2750508
Quantity 5 applications
Datasheet Datasheet

Aliases for MAP3K4 Proteins

mitogen activated protein kinase kinase kinase 4 (Map3k4) Proteins
mitogen-activated protein kinase kinase kinase 4 (MAP3K4) Proteins
mitogen-activated protein kinase kinase kinase 4 (Map3k4) Proteins
D17Rp17 Proteins
D17Rp17e Proteins
MAPKKK4 Proteins
Mek4b Proteins
MEKK4 Proteins
MEKK 4 Proteins
Mekk4 Proteins
mKIAA0213 Proteins
MTK1 Proteins
PRO0412 Proteins
RP17 Proteins
Rp17a Proteins
Tas Proteins
You are here:
Support