|Application / Reactivity||Mouse (Murine)||Human||Rat (Rattus)|
|Western Blotting (WB)||289 Antibodies||588 Antibodies||249 Antibodies|
|Proximity Ligation Assay (PLA)||2 Antibodies|
|Luminex Assay (LMNX)||6 Antibodies|
|Immunoprecipitation (IP)||41 Antibodies||60 Antibodies||39 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||106 Antibodies||57 Antibodies||48 Antibodies|
|Immunohistochemistry (IHC)||355 Antibodies||199 Antibodies||177 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||3 Antibodies||3 Antibodies||2 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||1 Antibodies||1 Antibodies||1 Antibodies|
|Antigen||Jun Proto-Oncogene (JUN) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This C-JUN antibody is un-conjugated Alternatives|
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Western Blotting (WB)
|7 references available|
|Supplier||Log in to see|
Product Details anti-C-JUN AntibodyTarget Details C-JUN Application Details Handling References for anti-C-JUN Antibody (ABIN967578) Images
|Cross-Reactivity (Details)||Predicted: Mouse, Rat|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
Target Details C-JUNProduct Details anti-C-JUN Antibody Application Details Handling References for anti-C-JUN Antibody (ABIN967578) Images back to top
|Alternative Name||C-Jun (JUN Antibody Abstract)|
The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation of serines 63 (S63) and 73 in its activation domain. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity.
The 2/c-Jun/(S63) monoclonal antibody recognizes the phosphorylated S63 of c-Jun.
|Molecular Weight||39 kDa|
|Pathways||MAPK Signaling, RTK Signaling, WNT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-C-JUN Antibody Target Details C-JUN Handling References for anti-C-JUN Antibody (ABIN967578) Images back to top
Related Products: ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-C-JUN Antibody Target Details C-JUN Application Details References for anti-C-JUN Antibody (ABIN967578) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-C-JUN Antibody (ABIN967578)Product Details anti-C-JUN Antibody Target Details C-JUN Application Details Handling Images back to top
|Product cited in:||
Weiss, Bohmann: "Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis." in: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 2, pp. 111-3, 2004 (PubMed).
Dunn, Wiltshire, MacLaren et al.: "Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor." in: Cellular signalling, Vol. 14, Issue 7, pp. 585-93, 2002 (PubMed).
Shaulian, Karin: "AP-1 in cell proliferation and survival." in: Oncogene, Vol. 20, Issue 19, pp. 2390-400, 2001 (PubMed).
Behrens, Sibilia, Wagner: "Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation." in: Nature genetics, Vol. 21, Issue 3, pp. 326-9, 1999 (PubMed).
Wisdom, Johnson, Moore: "c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms." in: The EMBO journal, Vol. 18, Issue 1, pp. 188-97, 1999 (PubMed).
Lamph, Wamsley, Sassone-Corsi et al.: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." in: Nature, Vol. 334, Issue 6183, pp. 629-31, 1988 (PubMed).
Smeal, Binetruy, Mercola et al.: "Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73." in: Molecular and cellular biology, Vol. 12, Issue 8, pp. 3507-13, 1992 (PubMed).
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