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Browse our CDT1 Proteins (CDT1)

Full name:
Chromatin Licensing and DNA Replication Factor 1 Proteins (CDT1)
On are 3 Chromatin Licensing and DNA Replication Factor 1 (CDT1) Proteins from 2 different suppliers available. Additionally we are shipping CDT1 Antibodies (55) and CDT1 Kits (5) and many more products for this protein. A total of 68 CDT1 products are currently listed.
2610318F11Rik, AW545653, C76791, CDT1, dup, fc37h07, im:7158083, ris2, wu:fc37h07, wu:fi38h09, xcdt1
list all proteins Gene Name GeneID UniProt
CDT1 81620 Q9H211
CDT1 67177 Q8R4E9
Rat CDT1 CDT1 292071  

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CDT1 Proteins (CDT1) by Origin

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More Proteins for CDT1 Interaction Partners

Zebrafish Chromatin Licensing and DNA Replication Factor 1 (CDT1) interaction partners

  1. DTL (show DTL Proteins) promotes genomic stability through two distinct mechanisms. First, it is an essential component of the CUL4-DDB1 (show DDB1 Proteins) complex that controls CDT1 levels, thereby preventing rereplication. Second, it is required for the early G2/M checkpoint.

Human Chromatin Licensing and DNA Replication Factor 1 (CDT1) interaction partners

  1. ATM (show ATM Proteins) silencing induced partial reduction in levels of Skp2, a component of SCF (show KITLG Proteins)(Skp2) ubiquitin ligase that controls Cdt1 degradation.

  2. FBXO31 (show FBXO5 Proteins) interacts with Cdt1 and regulates the degradation of Cdt1 in G2 phase.

  3. Protein levels of Geminin (show GMNN Proteins) and Cdt1 are tightly regulated through the cell cycle, and the Cdt1-Geminin (show GMNN Proteins) complex likely acts as a molecular switch that can enable or disable the firing of each origin of replication.

  4. These results demonstrate an important role for Cdt1 in human papillomavirus E7-induced rereplication and shed light on mechanisms by which human papillomavirus induces genomic instability.

  5. ATR (show ANTXR1 Proteins), activated after DNA damage, phosphorylates Cdt2 (show DTL Proteins) and promotes the rapid degradation of Cdt1 after UV irradiation in the G1 phase of the cell cycle.

  6. A lethal phenotype was seen in four individuals with compound heterozygous CDT1 mutations

  7. results support the conclusion that Cdt1 binding to Hec1 (show NDC80 Proteins) is essential for an extended Ndc80 (show NDC80 Proteins) configuration and stable kinetochore-microtubule attachment

  8. Genes in the erythroid differentiation and cell cycle regulation pathways influence interindividual variation in RBC (show CACNA1C Proteins) indices. Our results provide insights into the molecular basis underlying variation in RBC (show CACNA1C Proteins) traits.

  9. FOXO3 (show FOXO3 Proteins) is a binding partner of Cdt1.

  10. The over-expression of geminin (show GMNN Proteins) and cdt1 may play an important role in pathogenesis of acute leukemia.

Mouse (Murine) Chromatin Licensing and DNA Replication Factor 1 (CDT1) interaction partners

  1. Study shows that ablation of Geminin (show GMNN Proteins) induces massive rereplication as a result of unrestrained Cdt1 activity in embryonic stem cells, whereas it has no such effect in embryonic fibroblasts in which alternative regulation of Cdt1 activity is intact.

  2. This study reveals a conserved new regulatory Cdt1 domain crucial for proper DNA licensing activity.

  3. Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.

  4. Determined the structures of mCdt1CS (mCdt1C_small; residues 452 to 557) and mCdt1CL (mCdt1C_large; residues 420 to 557) using X-ray crystallography and NMR. This study reveals that Cdt1 is formed with a tandem repeat of the winged helix domain.

  5. Cdt1 function is negatively regulated by the Cdk (show CDK4 Proteins) phosphorylation independent of geminin (show GMNN Proteins) binding

  6. crystal structure of the mouse geminin (show GMNN Proteins)-Cdt1 complex using tGeminin (residues 79-157, truncated geminin (show GMNN Proteins)) and tCdt1 (residues 172-368, truncated Cdt1)

  7. In situ hybridization and immunohistochemistry localize Cdt1 as well as geminin (show GMNN Proteins) to the proliferative compartment of the developing mouse gut (show GUSB Proteins) epithelium

  8. Cdt1 expression characterizes progenitor cells in G1 phase

  9. These results suggested that, at least in vitro, oleic acid-containing cell membranes of the lipid bilayer inhibit Cdt1-geminin (show GMNN Proteins) complex formation by binding to Cdt1 and thereby liberating Cdt1 from inhibition by geminin (show GMNN Proteins).

  10. DNA binding and helicase activities of Mcm4 (show MCM4 Proteins)/6/7 are significantly stimulated by Cdt1

Xenopus laevis Chromatin Licensing and DNA Replication Factor 1 (CDT1) interaction partners

  1. These findings suggested that excess Cdt1 suppressed the progression of replication forks.

  2. Dynamic interactions of high Cdt1 and geminin (show GMNN Proteins) levels regulate S phase in early Xenopus embryos.

  3. p97 (show vcp Proteins) is an essential regulator of DNA damage-dependent CDT1 destruction

  4. CDC-48/p97 (show vcp Proteins) coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication

  5. Loading of geminin (show GMNN Proteins) onto chromatin requires Cdt1, suggesting that geminin (show GMNN Proteins) is targeted at replication origins.

  6. results allow us to build a comprehensive model of how re-replication of DNA is prevented in Xenopus, with Cdt1 regulation being the key feature

  7. Removal of Cdt1 from chromatin and its nuclear exclusion in G2 is critical in regulating licensing and limiting DNA replication in S phase to only one round.

  8. Cdt1 and DDB1 (show DDB1 Proteins) interact in extracts, and DDB1 (show DDB1 Proteins) chromatin loading is dependent on the binding of Cdt1 to PCNA (show PCNA Proteins), which indicates that PCNA (show PCNA Proteins) docking activates the pre-formed Cdt1-Cul4(DDB1 (show DDB1 Proteins)) ligase complex.

  9. These results suggest a model in which the MCM2-7 (show MCM2 Proteins) helicase is loaded onto chromatin by a Cdt1-geminin (show GMNN Proteins) complex, which is inactivated upon origin firing by binding additional geminin (show GMNN Proteins).

  10. Cdt1, with its two opposing regulatory binding factors MCM9 (show MCM9 Proteins) and geminin (show GMNN Proteins), appears to be a major platform on the pre-replication complexes to integrate cell-cycle signals.

CDT1 Protein Profile

Protein Summary

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein.

Alternative names and synonyms associated with CDT1

  • chromatin licensing and DNA replication factor 1 (CDT1)
  • chromatin licensing and DNA replication factor 1 (cdt1)
  • chromatin licensing and DNA replication factor 1 (Cdt1)
  • 2610318F11Rik protein
  • AW545653 protein
  • C76791 protein
  • CDT1 protein
  • dup protein
  • fc37h07 protein
  • im:7158083 protein
  • ris2 protein
  • wu:fc37h07 protein
  • wu:fi38h09 protein
  • xcdt1 protein

Protein level used designations for CDT1

chromatin licensing and DNA replication factor 1 , DNA replication factor Cdt1-like , DNA replication factor Cdt1 , Double parked, Drosophila, homolog of , DUP , double parked homolog , retroviral insertion site 2 protein , retroviral integration site 1 , retroviral integration site 2 , DNA replication factor

426254 Gallus gallus
479616 Canis lupus familiaris
566787 Danio rerio
100051139 Equus caballus
100379812 Xenopus (Silurana) tropicalis
100388665 Callithrix jacchus
100525749 Sus scrofa
100583916 Nomascus leucogenys
81620 Homo sapiens
67177 Mus musculus
292071 Rattus norvegicus
398024 Xenopus laevis
519016 Bos taurus
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