anti-Human Cortactin antibody for Enzyme Immunoassay

Recommended Cortactin Antibody (supplied by: Log in to see )

Antigen
Cortactin (CTTN) Antibodies
  • Cttn
  • CTTN
  • cttn
  • ems1
  • CG3637
  • Dmel\CG3637
  • cortactin
  • 1110020L01Rik
  • Ems1
  • CTTN1
  • P85.25
  • EMS1
  • Cttnb
  • cortactin
  • src substrate cortactin
  • Src substrate cortactin
  • CG3637 gene product from transcript CG3637-RD
  • CTTN
  • Cttn
  • cttn
  • CpipJ_CPIJ006351
  • Bm1_57220
  • LOC100533277
  • Cortactin
Epitope
AA 16-46, N-Term
29
20
17
14
14
9
8
7
4
4
4
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
202
126
76
8
8
6
4
3
3
3
3
1
1
1
1
1
1
Host
Rabbit
181
32
19
Clonality
Polyclonal
Conjugate
This Cortactin antibody is un-conjugated
4
4
4
4
4
4
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
208
102
90
39
23
18
13
5
3
2
2
2
1
1
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Catalog No. ABIN951670
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1106822 EIA IHC (p) WB Mouse IgG1 Log in to see 4C6 2
1 ABIN2718800 EIA IHC (p) WB Rabbit IgG Log in to see Polyclonal

General

Antigen Cortactin (CTTN) Antibodies
Epitope AA 16-46, N-Term
(29), (20), (17), (14), (14), (9), (8), (7), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(202), (126), (76), (8), (8), (6), (4), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1)
Host Rabbit
(181), (32), (19)
Clonality
Polyclonal
Conjugate This Cortactin antibody is un-conjugated
(4), (4), (4), (4), (4), (4)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(208), (102), (90), (39), (23), (18), (13), (5), (3), (2), (2), (2), (1), (1)
Pubmed 2 references available
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Product Details anti-Cortactin Antibody

Target Details Cortactin Application Details Handling References for anti-Cortactin antibody (ABIN951670) Images
Specificity This antibody recognizes Cortactin (SRC8) at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a Protein A column followed by peptide affinity purification
Immunogen Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 16-46aa) of human Cortactin (SRC8)
Isotype Ig

Target Details Cortactin

Product Details anti-Cortactin Antibody Application Details Handling References for anti-Cortactin antibody (ABIN951670) Images back to top
Antigen
Alternative Name Cortactin (CTTN Antibody Abstract)
Background SRC8 (CTTN) is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.Synonyms: Amplaxin, CTTN, EMS1, Oncogene EMS1
Gene ID 2017
NCBI Accession NP_005222
Research Area Cancer, Cell Cycle, Cytoskeleton, Microfilaments
Pathways MAPK Signaling

Application Details

Product Details anti-Cortactin Antibody Target Details Cortactin Handling References for anti-Cortactin antibody (ABIN951670) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Cortactin Antibody Target Details Cortactin Application Details References for anti-Cortactin antibody (ABIN951670) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-Cortactin antibody (ABIN951670)

Product Details anti-Cortactin Antibody Target Details Cortactin Application Details Handling Images back to top
Background publications

Xu, Garcia, Li, Khor, Gajapathy, Spittle, Weed, Lessin, Wu: "Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 23, Issue 2, pp. 187-96, 2010

Saitoh, Yumoto, Miwa: "alpha-tocopheryl phosphate suppresses tumor invasion concurrently with dynamic morphological changes and delocalization of cortactin from invadopodia." in: International journal of oncology, Vol. 35, Issue 6, pp. 1277-88, 2009

Images

Product Details anti-Cortactin Antibody Target Details Cortactin Application Details Handling References for anti-Cortactin antibody (ABIN951670) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Cortactin (CTTN) (AA 16-46), (N-Term) antibody (ABIN951670) Immunohistochemistry analysis of human breast carcinoma (Formalin-fixed, Paraffin-emb...
Western Blotting (WB) image for anti-Cortactin (CTTN) (AA 16-46), (N-Term) antibody (ABIN951670) Western blot analysis of Cortactin (arrow) in HL-60 cell line lysates (35ug/lane) usi...