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|Antigen||Mitogen-Activated Protein Kinase 8 (MAPK8) Antibodies|
|Epitope||AA 170-210, pThr183, pTyr185 Alternatives|
|Reactivity||Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This JNK antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|11 references available|
|Supplier||Log in to see|
Product Details anti-JNK AntibodyTarget Details JNK Application Details Handling References for anti-JNK antibody (ABIN732368) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human JNK1 around the phosphorylation site of Thr183/Tyr185|
Target Details JNKProduct Details anti-JNK Antibody Application Details Handling References for anti-JNK antibody (ABIN732368) Images back to top
|Alternative Name||JNK1 , 2 , 3 (MAPK8 Antibody Abstract)|
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
Subcellular location: Cytoplasm, Nucleus
Synonyms: JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2, Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, Stress-activated protein kinase 1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK8
|Pathways||MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor|
Application DetailsProduct Details anti-JNK Antibody Target Details JNK Handling References for anti-JNK antibody (ABIN732368) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-JNK Antibody Target Details JNK Application Details References for anti-JNK antibody (ABIN732368) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-JNK antibody (ABIN732368)Product Details anti-JNK Antibody Target Details JNK Application Details Handling Images back to top
|Product cited in:||
Ning, Wang, Gao, Mu, Wang, Liu, Zhu, Meng: "Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro." in: Molecular nutrition & food research, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).
Cong, Chen: "Neuroprotective Effect of Ginsenoside Rd in Spinal Cord Injury Rats." in: Basic & clinical pharmacology & toxicology, Vol. 119, Issue 2, pp. 193-201, 2016
Zhang, Lin, Jin, Lin, Cao, Zheng: "Overexpression of WNT5B promotes COLO 205 cell migration and invasion through the JNK signaling pathway." in: Oncology reports, Vol. 36, Issue 1, pp. 23-30, 2016
Iriyama, Hatta, Takei: "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes." in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, 2016
Yu, Shi, Qi, Zhao, Gao, Li: "Gypenoside Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of Mitogen-Activated Protein Kinase Mediated Nuclear Factor Kappa B Pathway In Vitro and In Vivo." in: Frontiers in pharmacology, Vol. 7, pp. 148, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).
Zhao, Xue, Guo, Sun, Liu, Wang: "Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension." in: International immunopharmacology, Vol. 42, pp. 115-121, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).
Zhao, Liu, Liu, Han, Zhao: "Betulin attenuates lung and liver injuries in sepsis." in: International immunopharmacology, Vol. 30, pp. 50-6, 2015
Król, Mucha, Majchrzak, Homa, Bulkowska, Majewska, Gajewska, Pietrzak, Perszko, Romanowska, Paw?owski, Manuali, Hellmen, Motyl: "Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors." in: PLoS ONE, Vol. 9, Issue 1, pp. e83995, 2014
Rosenzweig, Ou, Quinn: "P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture." in: Journal of cellular and molecular medicine, Vol. 17, Issue 4, pp. 508-17, 2013
Song, Liu, Li, Liu, Song, Song: "Protective effects of lipoic acid and mesna on cyclophosphamide-induced haemorrhagic cystitis in mice." in: Cell biochemistry and function, 2013
Rosenzweig, Djap, Ou, Quinn: "Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 20, Issue 12, pp. 1591-602, 2012
ImagesProduct Details anti-JNK Antibody Target Details JNK Application Details Handling References for anti-JNK antibody (ABIN732368) back to top