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anti-Xenopus laevis MAP2K1 antibody for Immunofluorescence

Recommended MAP2K1 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Antibodies
  • ATMEK1
  • CFC3
  • F20B18.180
  • F20B18_180
  • MAP kinase/ ERK kinase 1
  • MAPKK1
  • MEK
  • mek-2
  • MEK1
  • Mek1
  • MEKK1
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 1
  • MKK1
  • NMAPKK
  • PRKMK1
  • Prkmk1
  • si:ch211-242m18.2
  • wu:fj56a12
  • wu:fj61b01
  • zgc:56557
Epitope
N-Term
43
37
34
32
32
32
30
26
25
22
20
15
15
13
13
13
11
9
7
7
6
6
6
6
5
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
605
322
279
60
38
24
14
14
13
6
4
4
4
2
2
Host
Rabbit
492
123
2
2
1
Clonality
Polyclonal
Conjugate
This MAP2K1 antibody is un-conjugated
14
14
14
11
9
8
8
8
6
6
6
6
6
6
6
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
452
208
157
115
94
66
23
22
14
10
9
6
6
2
2
2
2
2
Supplier
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Catalog No. ABIN615073
$ 500.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0010843406 ABIN1736705 IF IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal
0.0010843406 ABIN2467433 IF IHC WB Rabbit N-Term Log in to see Polyclonal
0.0010843406 ABIN2449346 IF IHC WB Rabbit N-Term Log in to see Polyclonal

Similar anti-MAP2K1 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Xenopus laevis
Western Blotting (WB) 441 Antibodies 232 Antibodies 207 Antibodies 15 Antibodies
Proximity Ligation Assay (PLA) 2 Antibodies
Luminex Assay (LMNX) 10 Antibodies
Intracellular Staining (ICS) 9 Antibodies 9 Antibodies 3 Antibodies
Immunoprecipitation (IP) 14 Antibodies 10 Antibodies 8 Antibodies 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 96 Antibodies 49 Antibodies 44 Antibodies 2 Antibodies

General

Antigen Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Antibodies
Epitope N-Term
(43), (37), (34), (32), (32), (32), (30), (26), (25), (22), (20), (15), (15), (13), (13), (13), (11), (9), (7), (7), (6), (6), (6), (6), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(605), (322), (279), (60), (38), (24), (14), (14), (13), (6), (4), (4), (4), (2), (2)
Host Rabbit
(492), (123), (2), (2), (1)
Clonality
Polyclonal
Conjugate This MAP2K1 antibody is un-conjugated
(14), (14), (14), (11), (9), (8), (8), (8), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Application Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(452), (208), (157), (115), (94), (66), (23), (22), (14), (10), (9), (6), (6), (2), (2), (2), (2), (2)
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Product Details anti-MAP2K1 Antibody

Target Details MAP2K1 Application Details Handling Images
Specificity This antibody reacts to Mitogen-Activated Protein Kinase Kinase 1 (MEK1/MAP2K1).
Purification Protein A Chromatography
Immunogen MAP2K1 antibody was raised against synthetic peptide derived from sequence near the amino-terminus of human MEK1, conjugated to KLH Genename: MAP2K1

Target Details MAP2K1

Product Details anti-MAP2K1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name MAP2K1 (MAP2K1 Antibody Abstract)
Background MEK1, a MAP2K type protein kinase, is a member of the Ras MAPK pathway. This pathway modulates the activity of transcription factors, structural proteins and other protein kinases, leading to biological responses such as cell proliferation and differentiation. MEK1 contains a proline-rich segment that is recognized by the scaffold protein MEK binding partner-1 (MP1). MP1 associates with non-phosphorylated MEK1, forming a complex which associates with and phosphorylates MAP kinases ERK1 and 2. Additionally, MEK1 signaling is reported to have a strong negative effect on myogenic differentiation antigen (MYOD) activity via a mechanism involving the binding of MEK1 to the nuclear MYOD transcriptional complex. MEK1 is phosphorylated by several kinases, including Raf1, c-Mos and MEKK1. PAK1 also phosphorylates MEK1 resulting in enhancement of MEK's interaction with Raf-1. Constitutive activation of MEK1 results in cellular transformation, thus, it is a likely target for pharmacologic intervention in proliferative disease. MEK inhibitors have been studied for clinical management of colon cancer and inhibition of viral replication in host cells. MEK1 is a substrate for the anthrax lethal factor (LF).Synonyms: Dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAP kinase kinase 1, MAPK/ERK kinase 1, MAPKK 1, MEK1, PRKMK1
Gene ID 5604
NCBI Accession NP_002746
UniProt Q02750
Research Area Kinases/Phosphatases, Phospho-specific antibodies
Pathways MAPK Signaling, RTK Signaling, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-MAP2K1 Antibody Target Details MAP2K1 Handling Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-MAP2K1 Antibody Target Details MAP2K1 Application Details Images back to top
Concentration 1,0 mg/mL
Buffer PBS, pH 7.2, 50 % glycerol containing 0.09 % azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Images

Product Details anti-MAP2K1 Antibody Target Details MAP2K1 Application Details Handling back to top
Supplier Images
Immunofluorescence (IF) image for anti-MAP2K1 antibody (Mitogen-Activated Protein Kinase Kinase 1) (N-Term) (ABIN615073) Confocal immunofluorescent staining of HeLa cells using (green); nuclei are stained i...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MAP2K1 antibody (Mitogen-Activated Protein Kinase Kinase 1) (N-Term) (ABIN615073) Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with MAP2K1at 10 ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MAP2K1 antibody (Mitogen-Activated Protein Kinase Kinase 1) (N-Term) (ABIN615073) Human Prostate (formalin-fixed, paraffin-embedded) stained with MAP2K1at 10 µg/ml fol...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MAP2K1 antibody (Mitogen-Activated Protein Kinase Kinase 1) (N-Term) (ABIN615073) Human Tonsil (formalin-fixed, paraffin-embedded) stained with MAP2K1at 10 µg/ml follo...
Western Blotting (WB) image for anti-MAP2K1 antibody (Mitogen-Activated Protein Kinase Kinase 1) (N-Term) (ABIN615073) Western blot analysis of human thymus HS67 cell lysate