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Browse our MAP2K7 Proteins (MAP2K7)

Full name:
Mitogen-Activated Protein Kinase Kinase 7 Proteins (MAP2K7)
On www.antibodies-online.com are 10 Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) Proteins from 6 different suppliers available. Additionally we are shipping MAP2K7 Antibodies (128) and MAP2K7 Kits (11) and many more products for this protein. A total of 159 MAP2K7 products are currently listed.
Synonyms:
2, 5930412N11Rik, JNKK, JNKK 2, Jnkk2, MAP2K7, map2k7-A, MAPKK7, MAPKK 7, Mek7, MEK 7, MKK7, Prkmk7, SAPKK-4, SAPKK4, sek2, si:ch211-254d18.2
list all proteins Gene Name GeneID UniProt
MAP2K7 363855 Q4KSH7
MAP2K7 5609 O14733
MAP2K7 26400 Q8CE90

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MAP2K7 Proteins (MAP2K7) by Origin

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More Proteins for MAP2K7 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) interaction partners

  1. combined pan-RAF and MEK inhibition can overcome intrinsic and acquired resistance to single-agent RAF/MEK inhibition, supporting dual pan-RAF and MEK inhibition as a novel therapeutic strategy for BRAF- and KRAS-mutant cancers

  2. our study suggested that black rice anthocyanins extract suppress metastasis in breast cancer cells by targeting the RAS/RAF (show RAF1 Proteins)/MAPK (show MAPK1 Proteins) pathway

  3. Crystal structures of the wild type and C218S mutant of MAP2K7 were determined. Cys218 plays a crucial role in configuring an auto-inhibition form of MAP2K7.

  4. We found that the MKK7 p.Glu116Lys rare polymorphism was significantly associated with lung cancer risk, progression and prognosis

  5. we explored the effects of selumetinib in combination with gefitinib in a panel of TNBC cells, in order to evaluate whether the simultaneous blockade of the EGFR (show EGFR Proteins) and the RAS/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway might increase the antitumor activity of selumetinib in TNBC.

  6. a widespread role for the JNK (show MAPK8 Proteins)-CELF2 (show CELF2 Proteins) axis in controlling splicing during T-cell activation, including a specific role in propagating JNK (show MAPK8 Proteins) signaling.

  7. This review will focus on the science and clinical findings related to targeted therapies that inhibit BRAF (show BRAF Proteins) or MEK (show MAP2K1 Proteins) as well as the immunotherapies that block the CTLA-4 (show CTLA4 Proteins) or PD-1 (show PDCD1 Proteins) pathways

  8. BCR-ABL (show ABL1 Proteins) promotes PTEN downregulation through a MEK (show MAP2K1 Proteins) dependent pathway.

  9. The crystal structure of JNK1 (show MAPK8 Proteins) in complex with the second docking site of MKK7, was determined, revealing two different binding modes of the docking motif correlating with observations from NMR exchange spectroscopy.

  10. In conclusion, the expression of hepatitis B virus core protein sensitized hepatocytes to TNF-alpha (show TNF Proteins)-induced apoptosis by disrupting the interaction between MKK7 and RACK1 (show GNB2L1 Proteins).

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) interaction partners

  1. The loss of mkk4 (show MAP2K4 Proteins) and mkk7 locks damaged exocrine cells in a permanently de-differentiated state.

  2. Arrestin-3 (show ARRB2 Proteins) directly interacts with MKK7 and promotes JNK3alpha2 phosphorylation by both MKK4 (show MAP2K4 Proteins) and MKK7 in vitro as well as in intact cells.

  3. MKK7 is specifically phosphorylated in the neurite shaft which triggers Map1b phosphorylation to regulate microtubule bundling leading to neurite elongation.

  4. Data indicate that mitogen activated protein kinase kinase 7 (MKK7) plays a critical regulatory role in the c-Jun N-terminal kinase pathway in a murine model of rheumatoid arthritis.

  5. a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state.

  6. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.

  7. MKK4 (show MAP2K4 Proteins)/7 and JNK1 (show MAPK8 Proteins)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.

  8. This study demonistrated that Stress-activated protein kinase (show CDK7 Proteins) MKK7 regulates axon elongation in the developing cerebral cortex.

  9. The results reveal an essential role of MKK7 in cardiomyocytes for protecting the heart from hypertrophic insults thereby preventing the transition to heart failure.

  10. The role of NF-kappaB (show NFKB1 Proteins) and c-jun N-terminal kinase (JNK) activation in RANKL (show TNFSF11 Proteins)-induced osteoclast differentiation was investigated using an adenovirus vector carrying the dominant negative 1kappaB kinase 2 gene or dominant negative MKK7 gene.

MAP2K7 Protein Profile

Protein Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

Alternative names and synonyms associated with MAP2K7

  • mitogen-activated protein kinase kinase 7 (MAP2K7)
  • mitogen activated protein kinase kinase 7 (Map2k7)
  • mitogen-activated protein kinase kinase 7 (Map2k7)
  • mitogen-activated protein kinase kinase 7 (map2k7)
  • 2 protein
  • 5930412N11Rik protein
  • JNKK protein
  • JNKK 2 protein
  • Jnkk2 protein
  • MAP2K7 protein
  • map2k7-A protein
  • MAPKK7 protein
  • MAPKK 7 protein
  • Mek7 protein
  • MEK 7 protein
  • MKK7 protein
  • Prkmk7 protein
  • SAPKK-4 protein
  • SAPKK4 protein
  • sek2 protein
  • si:ch211-254d18.2 protein

Protein level used designations for MAP2K7

mitogen-activated protein kinase kinase 7 , JNK kinase 2 , JNK-activating kinase 2 , JNKK 2 , MAP kinase kinase 7 , MAPK/ERK kinase 7 , MAPKK 7 , MEK 7 , c-Jun N-terminal kinase kinase 2 , dual specificity mitogen-activated protein kinase kinase 7 , SAPK kinase 4 , stress-activated protein kinase kinase 4 , mitogen activated protein kinase kinase 7 , protein kinase, mitogen activated, kinase 7

GENE ID SPECIES
787278 Bos taurus
100302082 Ovis aries
363855 Rattus norvegicus
5609 Homo sapiens
485004 Canis lupus familiaris
26400 Mus musculus
560913 Danio rerio
394391 Xenopus laevis
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