MAP2K7 Products
(Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))
Categories
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008].
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Featured MAP2K7 Categories
MAP2K7 Antibodies
High quality antibodies with extensive validation data.
MAP2K7 ELISA Kits
Reliable ELISA kits for a wide range of species.
MAP2K7 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAP2K7 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (6)
Cat. No.
ABIN969271
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (7)
Cat. No.
ABIN3023157
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), PLA
Validations
- (5)
Cat. No.
ABIN562438
Quantity
100 μg
Datasheet
Datasheet
Recommended MAP2K7 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968653
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968652
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380777
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended MAP2K7 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN5569656
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569657
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN5570681
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our MAP2K7 products
: "Reactive oxygen species generated from skeletal muscles are required for gecko tail regeneration." in: Scientific reports, Vol. 6, pp. 20752, (2017) (PubMed).: "Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium." in: The Biochemical journal, Vol. 465, Issue 3, pp. 503-15, (2015) (PubMed).
: "Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation." in: The Biochemical journal, Vol. 427, Issue 2, pp. 237-45, (2010) (PubMed).
: "Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 5, pp. 3252-8, (2008) (PubMed).
: "Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK." in: Arthritis and rheumatism, Vol. 48, Issue 9, pp. 2450-60, (2003) (PubMed).
: "Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 15229-32, (2002) (PubMed).
: "Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest." in: Biochemical and biophysical research communications, Vol. 297, Issue 1, pp. 105-10, (2002) (PubMed).
Synonyms and alternative names related to MAP2K7
mitogen-activated protein kinase kinase 7 (MAP2K7), mitogen activated protein kinase kinase 7 (Map2k7), mitogen-activated protein kinase kinase 7 (Map2k7), mitogen-activated protein kinase kinase 7 (map2k7), mitogen-activated protein kinase kinase 7 L homeolog (map2k7.L), 2, 5930412N11Rik, JNKK, Jnkk2, JNKK 2, MAP2K7, map2k7-A, Mapkk7, MAPKK7, MAPKK 7, Mek7, MEK 7, Mkk7, MKK7, PRKMK7, Prkmk7, SAPKK-4, SAPKK4, sek2, si:ch211-254d18.2Protein level used designations for MAP2K7
- mitogen-activated protein kinase kinase 7
- JNK kinase 2
- JNK-activating kinase 2
- JNKK 2
- MAP kinase kinase 7
- MAPK/ERK kinase 7
- MAPKK 7
- MEK 7
- c-Jun N-terminal kinase kinase 2
- dual specificity mitogen-activated protein kinase kinase 7
- SAPK kinase 4
- stress-activated protein kinase kinase 4
- mitogen activated protein kinase kinase 7
- protein kinase, mitogen activated, kinase 7
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