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Browse our MAP3K11 Proteins (MAP3K11)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 11 Proteins (MAP3K11)
On www.antibodies-online.com are 5 Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11) Proteins from 3 different suppliers available. Additionally we are shipping MAP3K11 Antibodies (59) and many more products for this protein. A total of 68 MAP3K11 products are currently listed.
Synonyms:
2610017K16Rik, MEKK11, Mlk-3, Mlk3, PTK1, RHOE, SPRK
list all proteins Gene Name GeneID UniProt
MAP3K11 4296 Q16584
MAP3K11 26403 Q80XI6
Rat MAP3K11 MAP3K11 309168 Q66HA1

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MAP3K11 Proteins (MAP3K11) by Origin

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Human Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11) interaction partners

  1. During hepatocyte lipotoxicity, activated MLK3 induces the release of CXCL10 (show CXCL10 Proteins)-bearing vesicles from hepatocytes, which are chemotactic for macrophages.

  2. MLK3 serves as a common upstream kinase of AMPK (show PRKAA1 Proteins) and JNK (show MAPK8 Proteins) and functions as a direct upstream kinase for AMPK (show PRKAA1 Proteins) independent of LKB1 (show STK11 Proteins)

  3. MLK3 represents a newly recognized integral component of HER2 (show ERBB2 Proteins) biology in HER2 (show ERBB2 Proteins)+ breast tumors.

  4. MLK3 is a critical factor controlling the activity of kinase networks that control the cellular responses to different concentrations of reactive oxygen species.

  5. Signaling pathways associated with the Pro252His mutation in MLK3 are located in the kinase domain which is an important domain for the regulation of downstream signaling pathways.

  6. CHIP modulates MLK3 protein levels in response to Geldanamycin and stress stimuli, and CHIP-dependent regulation of MLK3 is required for suppression of SKOV3 ovarian cancer cell invasion.

  7. Data indicate URMC-099 as an orally bioavailable, potent mixed lineage kinase 3 MLK3 inhibitor.

  8. CTGF acting through Rac1 activates the MLK3/JNK signaling pathway, which in turn initiates AP-1 activation and recruitment of c-Jun and c-Fos to the collagen I promoter and ultimately induces collagen I expression in human lung fibroblasts

  9. NS5A targets MLK3 with multiple downstream consequences for both apoptosis and K(+) homeostasis.

  10. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 (show MAPK8IP1 Proteins) scaffold protein (show HOMER1 Proteins) in cytokine-induced pancreatic beta cell death

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11) interaction partners

  1. MAP3K11 might function as an important tumor suppressor neutralized by oncomiR-125b in B-cell leukemia.

  2. During hepatocyte lipotoxicity, activated MLK3 induces the release of CXCL10 (show CXCL10 Proteins)-bearing vesicles from hepatocytes, which are chemotactic for macrophages.

  3. TRB3 (show TRIB3 Proteins)(-/-) islets show a decrease in both the amplitude and duration of cytokine-stimulated MLK3 induction and JNK (show MAPK8 Proteins) activation.

  4. MLK3 limits RhoA (show RHOA Proteins) activation and injury-induced neointima formation by binding to and inhibiting the activation of p63Rho guanine nucleotide exchange factor (show ARHGEF12 Proteins), a RhoA (show RHOA Proteins) activator.

  5. Genetic or pharmacologic inhibition of MLK3 blocks fMLP (show FPR1 Proteins)-mediated motility of neutrophils both in vitro and in vivo, suggesting that MLK3 may be a therapeutic target in human diseases characterized by exuberant neutrophil migration.

  6. Data indicate URMC-099 as an orally bioavailable, potent mixed lineage kinase 3 MLK3 inhibitor.

  7. Data from knockout mice suggest that MLK3 plays role in saturated fatty acid-induced activation of MAP kinase (show MAPK1 Proteins) signaling; MLK3 appears to be involved in pathogenesis of obesity, adipose tissue in fl ammation, insulin (show INS Proteins) resistance, and fatty liver disease.

  8. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 (show MAPK8IP1 Proteins) scaffold protein (show HOMER1 Proteins) in cytokine-induced pancreatic beta cell death

  9. These results reveal a novel role for MLK3 signaling in the regulation of intestinal epithelial migration in vivo and suggest that MLK3 may be an important target for the regulation of intestinal mucosal healing.

  10. mice with a targeted deletion of Mlk3 displayed multiple skeletal defects, including dental abnormalities, deficient calvarial mineralization, and reduced bone mass

MAP3K11 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

Alternative names and synonyms associated with MAP3K11

  • mitogen-activated protein kinase kinase kinase 11 (MAP3K11)
  • mitogen-activated protein kinase kinase kinase 11 (Map3k11)
  • 2610017K16Rik protein
  • MEKK11 protein
  • Mlk-3 protein
  • Mlk3 protein
  • PTK1 protein
  • RHOE protein
  • SPRK protein

Protein level used designations for MAP3K11

SH3 domain-containing proline-rich kinase , mixed lineage kinase 3 , protein-tyrosine kinase PTK1 , src-homology 3 domain-containing proline-rich kinase , mitogen activated protein kinase kinase kinase 11

GENE ID SPECIES
4296 Homo sapiens
26403 Mus musculus
309168 Rattus norvegicus
483732 Canis lupus familiaris
514210 Bos taurus
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