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|Antigen||Mitogen-Activated Protein Kinase 14 (MAPK14) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This MAPK14 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-MAPK14 AntibodyTarget Details MAPK14 Application Details Handling References for anti-MAPK14 antibody (ABIN359424) Images
|Specificity||This antibody detects MAPK14.|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding T180 of human MAPK14.|
Target Details MAPK14Product Details anti-MAPK14 Antibody Application Details Handling References for anti-MAPK14 antibody (ABIN359424) Images back to top
|Alternative Name||MAP Kinase p38 alpha / MAPK14 (MAPK14 Antibody Abstract)|
|Background||MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.Synonyms: CSBP, CSBP1, CSBP2, CSPB1, Cytokine suppressive anti-inflammatory drug-binding protein, MAX-interacting protein 2, MXI2, Mitogen-activated protein kinase 14, SAPK2A, p38 alpha|
|Molecular Weight||41293 Da|
|Gene ID||1432, 9606|
|Pathways||MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagy, Thromboxane A2 Receptor Signaling|
Application DetailsProduct Details anti-MAPK14 Antibody Target Details MAPK14 Handling References for anti-MAPK14 antibody (ABIN359424) Images back to top
ELISA 1: 1,000. Western blot 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPK14 Antibody Target Details MAPK14 Application Details References for anti-MAPK14 antibody (ABIN359424) Images back to top
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.|
References for anti-MAPK14 antibody (ABIN359424)Product Details anti-MAPK14 Antibody Target Details MAPK14 Application Details Handling Images back to top
Cheung, Campbell, Nebreda, Cohen: "Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha." in: The EMBO journal, Vol. 22, Issue 21, pp. 5793-805, 2003
Dean, Sarsfield, Tsounakou, Saklatvala: "p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 39470-6, 2003
Sun, Liu, Nguyen, Bing: "P38 MAP kinase is activated at early stages in Alzheimer's disease brain." in: Experimental neurology, Vol. 183, Issue 2, pp. 394-405, 2003
Yustein, Xia, Kahlenburg, Robinson, Templeton, Kung: "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38." in: Oncogene, Vol. 22, Issue 40, pp. 6129-41, 2003
Frevel, Bakheet, Silva, Hissong, Khabar, Williams: "p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts." in: Molecular and cellular biology, Vol. 23, Issue 2, pp. 425-36, 2003
ImagesProduct Details anti-MAPK14 Antibody Target Details MAPK14 Application Details Handling References for anti-MAPK14 antibody (ABIN359424) back to top