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Elevated levels of p-Mnk1, p-eIF4E (show EIF4E ELISA Kits) and p-p70S6K (show RPS6KB1 ELISA Kits) proteins are associated with tumor recurrence and poor prognosis in astrocytomas. Overexpression of p-eIF4E (show EIF4E ELISA Kits) and co-expression of p-Mnk1, p-eIF4E (show EIF4E ELISA Kits) and p-p70S6K (show RPS6KB1 ELISA Kits) proteins could be used as novel independent poor prognostic biomarkers for patients with astrocytomas.
MNK-1 controls chemokine (show CCL1 ELISA Kits) secretion and proliferation in human airway smooth muscle cells.
MNK1 encodes a Ser/Thr protein kinase that interacts with extracellular signal-regulated kinase 1 (show MAPK3 ELISA Kits) and p38 mitogen-activated protein kinase (show MAPK14 ELISA Kits), a pathway that is involved in Blood Pressure regulation through norepinephrine and angiotensin II.
Data show that galeterone (gal (show GAL ELISA Kits)) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1/2-eIF4E (show EIF4E ELISA Kits) axis.
data suggest a physiological role for MNK1a-Ser (show SIGLEC1 ELISA Kits)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (show EIF4E ELISA Kits) phosphorylation in vitro and in vivo.
Data suggest MNK1/MNK2 (show MKNK2 ELISA Kits) stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (show EIF4E ELISA Kits) (via decreased binding to eIF4G (show EIF4G1 ELISA Kits)).
Simultaneous targeting of androgen receptor (show AR ELISA Kits) and MNK1 by novel retinamides inhibits growth of human prostate cancer cell lines.
MNK1 and MNK2 (show MKNK2 ELISA Kits) inhibition ablates eIF4E1 (show EIF4E ELISA Kits) phosphorylation and concurrently enhances eIF4E3 (show EIF4E3 ELISA Kits) expression in diffuse large B-cell lymphoma.
Data show that interferon-gamma (show IFNG ELISA Kits) regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E (show EIF4E ELISA Kits)).
Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML).
North American ginseng inhibits myocardial NOX2 (show CYBB ELISA Kits)-ERK1/2 (show MAPK1/3 ELISA Kits)-TNF-alpha (show TNF ELISA Kits) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (show GFAP ELISA Kits)-positive astrocytes for normal neurodevelopment.
These findings suggested that USP14 induces NF-kappaB (show NFKB1 ELISA Kits) activity and ERK1/2 (show MAPK1/3 ELISA Kits) phosphorylation triggered by microbial infection.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 (show MAPK3 ELISA Kits) or Erk2 (show MAPK1 ELISA Kits) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (show CD44 ELISA Kits) expression, and increased CD44 (show CD44 ELISA Kits) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (show ICAM1 ELISA Kits) and VCAM-1 (show VCAM1 ELISA Kits) by activating the ERK1/2 (show MAPK1/3 ELISA Kits) pathway, resulting in the expression of ETB (show EDNRB ELISA Kits) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (show NFkBP65 ELISA Kits), ERK1 (show MAPK3 ELISA Kits), ERK2 (show MAPK1 ELISA Kits) and STAT1 (show STAT1 ELISA Kits) pathways.
MAPK3 (show MAPK3 ELISA Kits)/1 participates in primordial follicle activation through mTORC1-KITL (show KITLG ELISA Kits) signaling.
At low oxLDL levels LOX-1 (show OLR1 ELISA Kits) activates the protective Oct-1 (show POU2F1 ELISA Kits)/SIRT1 (show SIRT1 ELISA Kits) pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 (show MAPK1/3 ELISA Kits) pathway.
Studies indicate that progesterone receptor (show PGR ELISA Kits) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (show CXCL9 ELISA Kits)-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (show MAPK1/3 ELISA Kits) and its target genes.
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.
MAP kinase interacting serine/threonine kinase 1
, MAP kinase-interacting serine/threonine-protein kinase 1
, MAP kinase signal-integrating kinase 1
, MAPK signal-integrating kinase 1
, MAP kinase 1
, MAP kinase 3
, MAP kinase isoform p44
, MAPK 1
, MAPK 3
, extracellular signal-regulated kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, mitogen-activated 3
, mitogen-activated protein kinase 1
, mitogen-activated protein kinase 3
, p44 MAP kinase
, pp42/MAP kinase