Browse our anti-MKNK2 (MKNK2) Antibodies

Full name:
anti-MAP Kinase Interacting serine/threonine Kinase 2 Antibodies (MKNK2)
On are 86 MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) Antibodies from 13 different suppliers available. Additionally we are shipping MKNK2 Proteins (10) and many more products for this protein. A total of 104 MKNK2 products are currently listed.
2010016G11Rik, Gprk7, mknk2, Mnk2, wu:fb37e05, wz5090
list all antibodies Gene Name GeneID UniProt
MKNK2 2872 Q9HBH9
MKNK2 17347 Q8CDB0
MKNK2 299618 Q5U2N4

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anti-Human MKNK2 Antibodies:

anti-Mouse (Murine) MKNK2 Antibodies:

anti-Rat (Rattus) MKNK2 Antibodies:

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Top referenced anti-MKNK2 Antibodies

  1. Human Polyclonal MKNK2 Primary Antibody for EIA, WB - ABIN359310 : Scheper, Parra, Wilson, Van Kollenburg, Vertegaal, Han, Proud: The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. in Molecular and cellular biology 2003 (PubMed)
    Show all 5 references for 359310

  2. Mouse (Murine) Polyclonal MKNK2 Primary Antibody for WB - ABIN657843 : Ueda, Sasaki, Elia, Chio, Hamada, Fukunaga, Mak: Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 references for 657843

  3. Cow (Bovine) Polyclonal MKNK2 Primary Antibody for IHC, WB - ABIN2786162 : Wang, Wang, Wang, Cai, Luo: Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex. in Science in China. Series C, Life sciences / Chinese Academy of Sciences 2006 (PubMed)

More Antibodies against MKNK2 Interaction Partners

Human MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) interaction partners

  1. Data show that galeterone (gal (show GAL Antibodies)) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1 (show MKNK1 Antibodies)/2-eIF4E (show EIF4E Antibodies) axis.

  2. Data suggest MNK1 (show MKNK1 Antibodies)/MNK2 stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (show EIF4E Antibodies) (via decreased binding to eIF4G (show EIF4G1 Antibodies)).

  3. MNK1 (show MKNK1 Antibodies) and MNK2 inhibition ablates eIF4E1 (show EIF4E Antibodies) phosphorylation and concurrently enhances eIF4E3 (show EIF4E3 Antibodies) expression in diffuse large B-cell lymphoma.

  4. Data show that interferon-gamma (show IFNG Antibodies) regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1 (show MKNK1 Antibodies)/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E (show EIF4E Antibodies)).

  5. Provide evidence for the existence of a Mnk2/eIF4E (show EIF4E Antibodies)-controlled feedback loop in medulloblastoma cells that accounts for resistance to mTORC1 inhibitors.

  6. Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML).

  7. These findings provide evidence for key and essential roles of the Mnk kinase pathway in the generation of the antineoplastic effects of type I IFNs in Jak2V617F-dependent myeloproliferative neoplasms.

  8. eIF4E (show EIF4E Antibodies) phosphorylation is enhanced by Rapamycin, which activates Mnk2a

  9. MNK2-dependent phosphorylation of eIF4E (show EIF4E Antibodies) represents a novel drug resistance, pro-survival pathway in pancreatic ductal carcinoma.

  10. siRNA-mediated Mnk1 (show MKNK1 Antibodies)/2 knockdown results in partial reversal of the suppressive effects of IFNgamma on human CD34 (show CD34 Antibodies)+-derived myeloid (CFU-GM) and erythroid (BFU-E) progenitors.

Mouse (Murine) MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) interaction partners

  1. MNK2 plays a role in adipogenesis and/or lipogenesis and in macrophage biology

  2. Data suggest that Mnk1 (show MKNK1 Antibodies) and Mnk2 regulate cell migration/wound healing, expression of vimentin (show VIM Antibodies), stability of vimentin (show VIM Antibodies) protein, and binding of eIF4E (eukaryotic translation initiation factor 4E (show EIF4E Antibodies)) and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (show CYFIP1 Antibodies)).

  3. Mnk2a directly interacts with and translocates p38alpha (show MAPK14 Antibodies)-MAPK (show MAPK1 Antibodies) into the nucleus. Alternatively, Mnk2b does not activate p38-MAPK (show MAPK14 Antibodies).

  4. eIF4E (show EIF4E Antibodies) phosphorylation is enhanced by Rapamycin, which activates Mnk2a

  5. Mnk1 (show MKNK1 Antibodies)/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 (show HAND1 Antibodies) and Th17 differentiation in vivo.

  6. Data indicate that MNK2 plays a unique role, not shared by its closest paralog MNK1 (show MKNK1 Antibodies), in limiting protein translation through its negative effect on eIF4G (show EIF4G1 Antibodies) Ser1108 phosphorylation and p70S6K (show RPS6KB1 Antibodies) activation.

  7. MAP kinase (show MAPK1 Antibodies)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.

  8. oncogenic role for Mnk1 (show MKNK1 Antibodies)/2 in tumor development

  9. Mnk2 and Mnk1 (show MKNK1 Antibodies) are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E (show EIF4EBP2 Antibodies) but not for cell growth or development

  10. The roles of features in the catalytic domains and C termini in determining the regulatory properties and basal activities of Mnk1 (show MKNK1 Antibodies) AND Mnk2 are reported.

MKNK2 Antigen Profile

Antigen Summary

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization.

Alternative names and synonyms associated with MKNK2

  • MAP kinase interacting serine/threonine kinase 2 (MKNK2) antibody
  • MAP kinase interacting serine/threonine kinase 2 (mknk2) antibody
  • MAP kinase-interacting serine/threonine kinase 2 (Mknk2) antibody
  • MAP kinase-interacting serine/threonine kinase 2b (mknk2b) antibody
  • 2010016G11Rik antibody
  • Gprk7 antibody
  • mknk2 antibody
  • Mnk2 antibody
  • wu:fb37e05 antibody
  • wz5090 antibody

Protein level used designations for MKNK2

MAP kinase interacting serine/threonine kinase 2 , MAP kinase-interacting serine/threonine kinase 2 , MAP kinase signal-integrating kinase 2 , MAP kinase-interacting serine/threonine-protein kinase 2 , MAPK signal-integrating kinase 2 , G protein-coupled receptor kinase 7 , mnk2

429269 Gallus gallus
455561 Pan troglodytes
780232 Xenopus (Silurana) tropicalis
100517077 Sus scrofa
2872 Homo sapiens
399068 Xenopus laevis
612212 Canis lupus familiaris
538519 Bos taurus
17347 Mus musculus
299618 Rattus norvegicus
373121 Danio rerio
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