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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|BioImaging (BI)||1 Antibodies|
|ELISA||52 Antibodies||60 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||3 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies||3 Antibodies|
|Immunochromatography (IC)||5 Antibodies||4 Antibodies|
|Immunocytochemistry (ICC)||11 Antibodies||12 Antibodies|
|Immunofluorescence (IF)||40 Antibodies||41 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||38 Antibodies||38 Antibodies|
|Immunohistochemistry (IHC)||123 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||33 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies|
|Western Blotting (WB)||142 Antibodies|
|Antigen||Stathmin 1 (STMN1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Stathmin 1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
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Product Details anti-Stathmin 1 AntibodyTarget Details Stathmin 1 Application Details Handling References for anti-Stathmin 1 Antibody (ABIN500417) Images
|Specificity||This antibody detects Stathmin / STMN1 at N-term.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, mouse, rat|
|Purification||Peptide affinity chromatography|
|Immunogen||Op18 antibody was raised against a 17 amino acid peptide from near the amino terminus of human op18.|
Target Details Stathmin 1Product Details anti-Stathmin 1 Antibody Application Details Handling References for anti-Stathmin 1 Antibody (ABIN500417) Images back to top
|Alternative Name||Stathmin / STMN1 (STMN1 Antibody Abstract)|
|Background||Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.Synonyms: LAP18, Leukemia-associated phosphoprotein p18, Metablastin, OP18, Oncoprotein 18, Op18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, pp19|
|Pathways||MAPK Signaling, Microtubule Dynamics|
Application DetailsProduct Details anti-Stathmin 1 Antibody Target Details Stathmin 1 Handling References for anti-Stathmin 1 Antibody (ABIN500417) Images back to top
ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Stathmin 1 Antibody Target Details Stathmin 1 Application Details References for anti-Stathmin 1 Antibody (ABIN500417) Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|
References for anti-Stathmin 1 Antibody (ABIN500417)Product Details anti-Stathmin 1 Antibody Target Details Stathmin 1 Application Details Handling Images back to top
Mizumura, Takeda, Hashimoto et al.: "Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade." in: Journal of cellular physiology, Vol. 206, Issue 2, pp. 363-70, 2005 (PubMed).
Curmi, Gavet, Charbaut et al.: "Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin." in: Cell structure and function, Vol. 24, Issue 5, pp. 345-57, 2004 (PubMed).
Mistry, Atweh: "Role of stathmin in the regulation of the mitotic spindle: potential applications in cancer therapy." in: The Mount Sinai journal of medicine, New York, Vol. 69, Issue 5, pp. 299-304, 2002 (PubMed).
Belmont, Mitchison: "Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules." in: Cell, Vol. 84, Issue 4, pp. 623-31, 1996 (PubMed).
ImagesProduct Details anti-Stathmin 1 Antibody Target Details Stathmin 1 Application Details Handling References for anti-Stathmin 1 Antibody (ABIN500417) back to top