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Browse our Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1)

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Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1)
On www.antibodies-online.com are 8 Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) Proteins from 5 different suppliers available. Additionally we are shipping Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Antibodies (155) and Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Kits (42) and many more products for this protein. A total of 212 Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 products are currently listed.
Synonyms:
Ar, ArKO, aro, ARO1, Aromatase, CPV1, CYAR, cyp19, cyp19a, CYP19A1, CYP19P1, CYPXIX, Int-5, Int5, P-450AROM, P450 arom, P450AROM, p450arom-A
list all proteins Gene Name GeneID UniProt
CYP19A1 1588 P11511
CYP19A1 25147  
CYP19A1 13075 P28649

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Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1) by Origin

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More Proteins for Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Interaction Partners

Pig (Porcine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. P450arom was expressed in all layers of the arterial and venous vessels of the spermatic cord with higher intensity of staining in June long daylight) compared to December(short daylight).

  2. Decreased estradiol production via suppression of aromatase may be one of the mechanisms by which miR (show MYLIP Proteins)-378 regulates the maturation of cumulus-oocyte complexes.

  3. show that micro-RNA378 (miR (show MYLIP Proteins)-378) is spatiotemporally expressed in porcine granulosa cells, the cells that generate estradiol in the ovary during follicular development, in an inverse manner compared with the expression of aromatase

  4. Pig ejaculated spermatozoa express aromatase.

  5. The presence of aromatase and 11beta-HSD 2 (show HSD11B2 Proteins) in Leydig cells increased, together with germ and Sertoli cell numbers.

  6. This study demonstrates that transferrin (show Tf Proteins) had a dose-dependent inhibitory effect on follicle stimulating hormone-stimulated aromatase activity.

Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. Significant reduction of CYP19A1 gene expression in Cumulus cells of endometriosis patients may be the result of epigenetic alterations in its regulatory regions, either by DNA methylation (show HELLS Proteins) or histone modifications.

  2. we genotyped five hormone-related genes: estrogen receptor-alpha (ESR1 (show ESR1 Proteins)), aromatase (CYP19), catechol-O-methyl transferase (COMT (show COMT Proteins)), sex hormone-binding globulin (SHBG (show SHBG Proteins))and glutathione S-transferase (show GSTa2 Proteins) (GSTP1 (show GSTP1 Proteins)). Our data demonstrate that these ESR1 (show ESR1 Proteins), GSTP1 (show GSTP1 Proteins), and CYP19 polymorphisms are associated with risk of BC, and the risk haplotype TGGGGTC could help to identify populations with high susceptibility to BC in Chinese women.

  3. In the bone marrow, cyclin A1 (show CCNA1 Proteins) and aromatase enhanced local bone marrow-releasing factors, including androgen receptor (show AR Proteins), estrogen and matrix metalloproteinase (show MMP20 Proteins) MMP9 (show MMP9 Proteins) and promoted the metastatic growth of prostate cancer cells

  4. No association of functional polymorphisms in the estrogen metabolism genes CYP19A1 with menstrual migraine.

  5. The results demonstrated that the rs3751592 A/G polymorphism of the CYP19A1 gene was associated with the incidence of Alzheimer disease in a Chinese Han population, which suggests that CYP19A1 rs3751592 is a predisposing genetic factor for Alzheimer disease.

  6. CYP19 Gene Polymorphism is associated with Breast Cancer.

  7. The data showed that the effect of Activin A (show INHBA Proteins) on ESCs (show NR2E3 Proteins) was partially abrogated by pretreatment with an inhibitor of ALK4 (show ACVR1B Proteins) (the type I receptor, ActRIB (show ACVR1B Proteins)) and Smad4 (show SMAD4 Proteins)-siRNA. Cumulatively, these data suggest that Activin A (show INHBA Proteins) promotes the secretion of estradiol from ESCs (show NR2E3 Proteins) by increasing the expression of P450arom via the ALK4 (show ACVR1B Proteins)-Smad (show SMAD1 Proteins) pathway. These findings indicate the ALK4 (show ACVR1B Proteins)-Smad (show SMAD1 Proteins) pathway may promote ectopic lesion survival and developmen

  8. Results show downregulation of CYP19A1 mRNA level in postmenopausal invasive ductal cancer which correlates with tumor prognosis.

  9. Present meta-analysis reveals that CYP19 rs10046 polymorphism may be not correlated to endometriosis risk.

  10. results indicated that there was a significant association between migraine and gene-gene interaction among the CYP19A1, FSHR (show FSHR Proteins), ESR1 (show ESR1 Proteins) and NRIP1 (show NRIP1 Proteins).

Cow (Bovine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. in granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons

  2. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.

  3. This study evaluated the relationships among aromatase, IGF-1 (show IGF1 Proteins), IGF2R (show IGF2R Proteins), and FSH (show BRD2 Proteins) levels expressed in ovarian follicles of cattle selected for twin pregnancies.

  4. Data indicated de novo DNA methylation (show HELLS Proteins) fter the luteinizing hormone-induced down-regulation of CYP19A1 expression, suggesting that DNA methylation (show HELLS Proteins) might play a role for permanent silencing of previously down-regulated genes.

  5. P450(AROM) is localized in the cytoplasm and only seldom present in the fine extensions of the cells in frontal cortex.

  6. Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1 (show HSD3B1 Proteins), and CYP17A1 (show CYP17A1 Proteins) transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.

  7. DNA methylation (show HELLS Proteins) may have a role in the permanent shutdown of promoter 2-directed cytochrome P450 19A1(CYP19A1) expression in large (granulosa derived) lutein cells

  8. fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary

  9. granulosa cell clustering is accompanied by marked increases in FSHr (show FSHR Proteins), IGF-1r (show IGF1R Proteins), and p450 arom expression, and precedes induction and subsequent peak E2 production

  10. demonstrates that cattle and sheep use different promoters to direct aromatase(Cyp19) expression during pregnancy

Mouse (Murine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. aromatase could modulate pituitary LH-positive cells in males through local estradiol synthesis.

  2. Findings indicate that sex chromosome factors determine sex differences in aromatase expression in the stria terminalis and in the anterior amygdaloid area of mouse embryos.

  3. CELF1 (show CELF1 Proteins) downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.

  4. Aromatase plays an important role in the survival of metastatic ERalpha (show ESR1 Proteins) breast cancer cells by suppressing anoikis.

  5. aromatase may play a key role in the pathogenesis of Sjogren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage; increased MPC1 (show BRP44L Proteins) protein expression has a role in adiposity

  6. The protective effect of female gender on abdominal aortic aneurysms is due to estrogen synthesis and requires the presence of both ovarian and extragonadal/peripheral aromatase.

  7. Aromatase signaling is common in the mouse brain; locally synthesized brain estrogens could mediate biological effects by activating pre- and post-synaptic estrogen alpha and beta receptors, and androgen receptors.

  8. Male Aromatase knockout mice develop hepatic glucose intolerance.

  9. Cerebrovascular endothelial aromatase plays an important and sexually dimorphic role in cerebrovascular function and that aromatase inhibitors in clinical use may have cardiovascular consequences in both males and females.

  10. CYP19A1 gene is driven by promoters PII, I.4, and I.3 in the seminal vesicles, and by promoters PII and I.4 in the urinary bladder.

Horse (Equine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. co-localization of estrogen receotirs with aromatase in horse trophoblast suggests auto- or intracrine functions of oestrogens in this cell type

Goat Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.

  2. Relative mRNA expression for insulin (show INS Proteins) and FSH (show BRD2 Proteins) receptors and cytochrome P450 aromatase in cultured follicles.

Xenopus laevis Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. We found that cyp19a1 expression is highly regionalized in the brains of both sexes.

  2. Cyp19a1 expression leads to female sex determination in Xenopus laevis.

  3. brain-specific (show CALY Proteins) promoter/exon I.f of the cyp19a1 has cis (show CISH Proteins)-elements for several transcriptional factors

  4. binding sequences to a specific trans-activating factor upstream of the p450 (show POR Proteins) aromatase promoter II

  5. The ontogenetic patterns of Aro, Srd5a1 (show SRD5A1 Proteins) and Srd5a2 (show SRD5A2 Proteins) suggest that these genes are involved in sexual differentiation of gonads and brain already in early developmental stages.

Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity\; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.

Alternative names and synonyms associated with Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1)

  • aromatase (SAV_2383)
  • cytochrome P450 aromatase (pfcyp19b-tstr)
  • cytochrome P450 19A1 (CYP19A1)
  • cytochrome P450 19A3 (CYP19A3)
  • cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP19A1)
  • cytochrome P450, family 19 (CYP19)
  • cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1)
  • cytochrome P450, family 19, subfamily a, polypeptide 1 (Cyp19a1)
  • cytochrome P450, family 19, subfamily A, polypeptide 1 (cyp19a1)
  • Ar protein
  • ArKO protein
  • aro protein
  • ARO1 protein
  • Aromatase protein
  • CPV1 protein
  • CYAR protein
  • cyp19 protein
  • cyp19a protein
  • CYP19A1 protein
  • CYP19P1 protein
  • CYPXIX protein
  • Int-5 protein
  • Int5 protein
  • P-450AROM protein
  • P450 arom protein
  • P450AROM protein
  • p450arom-A protein

Protein level used designations for CYP19A1

aromatase , cytochrome P450 aromatase , CYPXIXA1 , cytochrome P-450AROM , cytochrome P450 19 type I , cytochrome P450, family19, subfamily A, polypeptide 1 , estrogen synthase , CYPXIXA3 , aromatase cytochrome P450 , cytochrome P450 19 type III , cytochrome P450, family 19, subfamily A, polypeptide 3 , type I cytochrome p450 aromatase , CYPXIX , cytochrome P450 19A1 , estrogen synthetase , cytochrome P450, subfamily XIX (aromatization of androgens) , flavoprotein-linked monooxygenase , microsomal monooxygenase , Cytochrome P450, 19, aromatase , P-450AROM , cytochrome P450 family 19 subfamily a , cytochrome P450, subfamily 19 , cytochrome P450, family XIX (conversion of androgen to estrogen), aromatase , cytochrome P450, 19, aromatase , cytochrome P450 17-alpha , Cytochrome P-450AROM , Cytochrome P450 19A1 , Estrogen synthase , p450 aromatase A

GENE ID SPECIES
1213743 Streptomyces avermitilis MA-4680
100379639 Takifugu rubripes
403331 Sus scrofa
403333 Sus scrofa
494003 Canis lupus familiaris
100144423 Ovis aries
414854 Gallus gallus
1588 Homo sapiens
25147 Rattus norvegicus
281740 Bos taurus
13075 Mus musculus
100009712 Equus caballus
100328545 Oryctolagus cuniculus
100861413 Capra hircus
373656 Xenopus laevis
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