You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1)

Full name:
Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1)
On www.antibodies-online.com are 8 Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) Proteins from 5 different suppliers available. Additionally we are shipping Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Antibodies (155) and Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Kits (51) and many more products for this protein. A total of 222 Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 products are currently listed.
Synonyms:
Ar, ArKO, aro, ARO1, Aromatase, CPV1, CYAR, cyp19, cyp19a, CYP19A1, CYP19P1, CYPXIX, Int-5, Int5, P-450AROM, P450 arom, P450AROM, p450arom-A
list all proteins Gene Name GeneID UniProt
CYP19A1 1588 P11511
CYP19A1 25147  
CYP19A1 13075 P28649

Show all synonyms

Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1) by Origin

Select your origin of interest

More Proteins for Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Interaction Partners

Pig (Porcine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. CYP19A1 is involved in sperm fertility and its expression in sperm plays an important role in fertilization.

  2. P450arom was expressed in all layers of the arterial and venous vessels of the spermatic cord with higher intensity of staining in June long daylight) compared to December(short daylight).

  3. Decreased estradiol production via suppression of aromatase may be one of the mechanisms by which miR (show MYLIP Proteins)-378 regulates the maturation of cumulus-oocyte complexes.

  4. show that micro-RNA378 (miR (show MYLIP Proteins)-378) is spatiotemporally expressed in porcine granulosa cells, the cells that generate estradiol in the ovary during follicular development, in an inverse manner compared with the expression of aromatase

  5. Pig ejaculated spermatozoa express aromatase.

  6. The presence of aromatase and 11beta-HSD 2 (show HSD11B2 Proteins) in Leydig cells increased, together with germ and Sertoli cell numbers.

  7. This study demonstrates that transferrin (show Tf Proteins) had a dose-dependent inhibitory effect on follicle stimulating hormone-stimulated aromatase activity.

Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. Estradiol synthesis in the hippocampus is regulated by several mechanisms, which are reviewed in this report. The regulation of the activity of aromatase, the final enzyme of estrogen biosynthesis, by Ca(2 (show CA2 Proteins)+) transients, is of particular interest. [review]

  2. CYP19A1 activity may contribute to disordered steroidogenesis in female patients with POR (show POR Proteins) mutations as well as in mothers with POR (show POR Proteins) variants carrying a male child

  3. deregulation of miR (show MLXIP Proteins)-320a/RUNX2 (show RUNX2 Proteins)/CYP11A1 (show CYP11A1 Proteins) (CYP19A1) cascade plays an important role in the development of estrogen deficiency in human cumulus granulosa cells

  4. The structural and functional importance of estrogen receptor (show ESR1 Proteins) and aromatase in endocrine-responsive and -resistant breast cancers will be discussed in more detail. [review]

  5. Aromatase inhibitor treatment significantly increased expression of let-7f in Ishikawa cells and endometrial stroma cells from patients with endometriosis.

  6. results show that the Aha1 (show AHSA1 Proteins)-Hsp90 (show HSP90 Proteins)-PKM2/HIF-1alpha (show HIF1A Proteins) axis mediates the induction of aromatase in Li-Fraumeni Syndrome (show TP53 Proteins).

  7. Data show that the combination of nobiletin (NOB (show NYX Proteins)), hesperetin (HES (show RRBP1 Proteins)) and letrozole (LET) had no effects on activity and expression of aromatase (cytochrome P450 CYP19) in MCF-7 breast cancer cells.

  8. The expression of P450 (show CYP2B6 Proteins) aromatase corresponds to specific cell morphology in sex cord-stromal tumors, including recurrent tumors.

  9. Association study investigated the ESR1 (show ESR1 Proteins), ESR2 (show ESR2 Proteins), and CYP19A1 gene polymorphisms in Chinese migraine patients, data suggested that ESR1 (show ESR1 Proteins) rs2234693 plays a potential role in migraine susceptibility in a Chinese population, especially for menstrually related migraine

  10. A novel 568C insertion mutation in CYP19A1 can lead to severe aromatase deficiency. Homozygosity for this mutation is associated with the development of hypoplastic ovaries

Cow (Bovine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. in granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons

  2. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.

  3. This study evaluated the relationships among aromatase, IGF-1 (show IGF1 Proteins), IGF2R (show IGF2R Proteins), and FSH (show BRD2 Proteins) levels expressed in ovarian follicles of cattle selected for twin pregnancies.

  4. Data indicated de novo DNA methylation (show HELLS Proteins) fter the luteinizing hormone-induced down-regulation of CYP19A1 expression, suggesting that DNA methylation (show HELLS Proteins) might play a role for permanent silencing of previously down-regulated genes.

  5. P450(AROM) is localized in the cytoplasm and only seldom present in the fine extensions of the cells in frontal cortex.

  6. Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1 (show HSD3B1 Proteins), and CYP17A1 (show CYP17A1 Proteins) transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.

  7. DNA methylation (show HELLS Proteins) may have a role in the permanent shutdown of promoter 2-directed cytochrome P450 19A1(CYP19A1) expression in large (granulosa derived) lutein cells

  8. fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary

  9. granulosa cell clustering is accompanied by marked increases in FSHr (show FSHR Proteins), IGF-1r (show IGF1R Proteins), and p450 arom expression, and precedes induction and subsequent peak E2 production

  10. demonstrates that cattle and sheep use different promoters to direct aromatase(Cyp19) expression during pregnancy

Mouse (Murine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. results show that the Aha1 (show AHSA1 Proteins)-Hsp90 (show HSP90 Proteins)-PKM2/HIF-1alpha (show HIF1A Proteins) axis mediates the induction of aromatase in Li-Fraumeni Syndrome (show TP53 Proteins).

  2. aromatase could modulate pituitary LH-positive cells in males through local estradiol synthesis.

  3. Findings indicate that sex chromosome factors determine sex differences in aromatase expression in the stria terminalis and in the anterior amygdaloid area of mouse embryos.

  4. CELF1 (show CELF1 Proteins) downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.

  5. Aromatase plays an important role in the survival of metastatic ERalpha (show ESR1 Proteins) breast cancer cells by suppressing anoikis.

  6. aromatase may play a key role in the pathogenesis of Sjogren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage; increased MPC1 (show BRP44L Proteins) protein expression has a role in adiposity

  7. The protective effect of female gender on abdominal aortic aneurysms is due to estrogen synthesis and requires the presence of both ovarian and extragonadal/peripheral aromatase.

  8. Aromatase signaling is common in the mouse brain; locally synthesized brain estrogens could mediate biological effects by activating pre- and post-synaptic estrogen alpha and beta receptors, and androgen receptors.

  9. Male Aromatase knockout mice develop hepatic glucose intolerance.

  10. Cerebrovascular endothelial aromatase plays an important and sexually dimorphic role in cerebrovascular function and that aromatase inhibitors in clinical use may have cardiovascular consequences in both males and females.

Horse (Equine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. co-localization of estrogen receotirs with aromatase in horse trophoblast suggests auto- or intracrine functions of oestrogens in this cell type

Goat Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.

  2. Relative mRNA expression for insulin (show INS Proteins) and FSH (show BRD2 Proteins) receptors and cytochrome P450 aromatase in cultured follicles.

Xenopus laevis Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. We found that cyp19a1 expression is highly regionalized in the brains of both sexes.

  2. Cyp19a1 expression leads to female sex determination in Xenopus laevis.

  3. brain-specific (show CALY Proteins) promoter/exon I.f of the cyp19a1 has cis (show CISH Proteins)-elements for several transcriptional factors

  4. binding sequences to a specific trans-activating factor upstream of the p450 (show POR Proteins) aromatase promoter II

  5. The ontogenetic patterns of Aro, Srd5a1 (show SRD5A1 Proteins) and Srd5a2 (show SRD5A2 Proteins) suggest that these genes are involved in sexual differentiation of gonads and brain already in early developmental stages.

Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity\; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.

Alternative names and synonyms associated with Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1)

  • aromatase (SAV_2383)
  • cytochrome P450 aromatase (pfcyp19b-tstr)
  • cytochrome P450 19A1 (CYP19A1)
  • cytochrome P450 19A3 (CYP19A3)
  • cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP19A1)
  • cytochrome P450, family 19 (CYP19)
  • cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1)
  • cytochrome P450, family 19, subfamily a, polypeptide 1 (Cyp19a1)
  • cytochrome P450, family 19, subfamily A, polypeptide 1 (cyp19a1)
  • Ar protein
  • ArKO protein
  • aro protein
  • ARO1 protein
  • Aromatase protein
  • CPV1 protein
  • CYAR protein
  • cyp19 protein
  • cyp19a protein
  • CYP19A1 protein
  • CYP19P1 protein
  • CYPXIX protein
  • Int-5 protein
  • Int5 protein
  • P-450AROM protein
  • P450 arom protein
  • P450AROM protein
  • p450arom-A protein

Protein level used designations for CYP19A1

aromatase , cytochrome P450 aromatase , CYPXIXA1 , cytochrome P-450AROM , cytochrome P450 19 type I , cytochrome P450, family19, subfamily A, polypeptide 1 , estrogen synthase , CYPXIXA3 , aromatase cytochrome P450 , cytochrome P450 19 type III , cytochrome P450, family 19, subfamily A, polypeptide 3 , type I cytochrome p450 aromatase , CYPXIX , cytochrome P450 19A1 , estrogen synthetase , cytochrome P450, subfamily XIX (aromatization of androgens) , flavoprotein-linked monooxygenase , microsomal monooxygenase , Cytochrome P450, 19, aromatase , P-450AROM , cytochrome P450 family 19 subfamily a , cytochrome P450, subfamily 19 , cytochrome P450, family XIX (conversion of androgen to estrogen), aromatase , cytochrome P450, 19, aromatase , cytochrome P450 17-alpha , Cytochrome P-450AROM , Cytochrome P450 19A1 , Estrogen synthase , p450 aromatase A

GENE ID SPECIES
1213743 Streptomyces avermitilis MA-4680
100379639 Takifugu rubripes
403331 Sus scrofa
403333 Sus scrofa
494003 Canis lupus familiaris
100144423 Ovis aries
414854 Gallus gallus
1588 Homo sapiens
25147 Rattus norvegicus
281740 Bos taurus
13075 Mus musculus
100009712 Equus caballus
100328545 Oryctolagus cuniculus
100861413 Capra hircus
373656 Xenopus laevis
Selected quality suppliers for Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1)
Did you look for something else?