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This is the first study to indicate that 3beta-HSD (show CHST3 ELISA Kits) type 1 is a potent prognostic factor in hormone-dependent breast cancer.
HSD3B1 is involved in aldosterone production, despite its lower levels of expression compared with HSD3B2 (show HSD3B2 ELISA Kits), and also possibly associated with KCNJ5 (show KCNJ5 ELISA Kits) mutation in aldosterone-producing adenoma.
Expression of the genes HSD3B1, HSD17B3 (show HSD17B3 ELISA Kits), and SRD5A2 (show SRD5A2 ELISA Kits) was significantly increased in BPH (show GLI3 ELISA Kits) tissues compared to normal adjacent prostate tissues.
prostate cancer patients who harbored the heterozygous variant HSD3B1 (1245C) are more likely to develop to castration-resistant prostate cancer but do not have shorter time to biochemical recurrence, shorter survival time or higher mortality risk
No evidence to support that HSD3B1 is involved in aldosterone synthesis in the human adrenal cortex or that genetic variation in HSD3B1 affects blood pressure or hypertension.
Results indicate that orexin-A significantly enhanced the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD (show CHST3 ELISA Kits)) and the production of cortisol, and increased the phosphorylation of AKT (show AKT1 ELISA Kits) protein in the NCI-H295R adrenocortical cells.
The AngII-NGFIB/NURR1 (show NR4A2 ELISA Kits) pathway controls HSD3B1 expression.
The AAT haplotype of the HSD3B1 gene was significantly associated with increased risks of acne vulgaris in Han Chinese from the Southwest China.
HSD3B1 T-->C Leu338, HTR2A T102C, GNAS (show GNAS ELISA Kits) T393C, and RGS2 (show RGS2 ELISA Kits) G638A polymorphisms were not associated with hypertension risk.
Risk-conferring genetic variations in the HSD3beta gene influenced susceptibility of primary aldosteronism. Concomitant presence of rs6203 CC and rs12410453 GA genotypes synergistically increased aldosterone-to-renin (show REN ELISA Kits) ratio
We found that adiponectin and insulin (show INS ELISA Kits) alone regulates the expression of StAR, CYP11A1 (show CYP11A1 ELISA Kits) and HSD3B1 genes and secretion of P4 and A4 by the porcine endometrial and myometrial tissue explants during early pregnancy and the oestrous cycle.
The effects of androgen blockade on the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD (show HAL ELISA Kits)), CYP17 (show CYP17A1 ELISA Kits), and 17beta-hydroxysteroid dehydrogenase (show HSD17B7 ELISA Kits) type 1 (17beta-HSD1 (show SPAG8 ELISA Kits)) in the porcine fetus are reported.
Study found that uncastrated Duroc pigs with the GG SNP5 genotype had significantly higher 3beta-HSD (show HAL ELISA Kits) mRNA levels than did uncastrated Duroc pigs with other SNP5 genotypes.
Significant sequence variations were found in the 5'flanking region of the 3beta-HSD (show HAL ELISA Kits) gene, where differences in the number of TTAT repeats and 3 SNP were observed in the different breeds
The expression of 3betaHSD mRNA was detected by the use of RT-PCR technique in all investigated samples isolated at different stages of pregnancy.
Genistein and daidzein have direct effects on porcine granulosa cell progesterone synthesis involving the inhibition of 3-beta-HSD enzyme activity.
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1 (show CYP19A1 ELISA Kits), HSD3B1, and CYP17A1 (show CYP17A1 ELISA Kits) transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
Serum free culture conditions significantly enhanced Cyp17 (show CYP17A1 ELISA Kits) and Csh1 but not Hsd3b expression in trophoblast.
LH induction of 3beta-HSD (show HAL ELISA Kits) in nonpregnant mouse endometrium.
HIF-1alpha (show HIF1A ELISA Kits) is constitutively present in the Leydig cells of the murine testis, where it potentially regulates Hsd3b1 transcription, and thus male reproductive function.
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
3 beta-hydroxysteroid dehydrogenase
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
, 3-beta-HSD I
, 3-beta-hydroxy-5-ene steroid dehydrogenase
, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase
, delta-5-3-ketosteroid isomerase
, hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1
, progesterone reductase
, short chain dehydrogenase/reductase family 11E, member 1
, steroid Delta-isomerase
, trophoblast antigen FDO161G
, 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase
, hydroxy-delta-MAY-steroid dehydrogenase, 3 beta- and steroid delta-isomerase
, hydroxysteroid dehydrogenase-1, delta<5>-3-beta
, 3 beta-hydroxysteroid dehydrogenase 1
, 3-beta-hydroxysteroid dehydrogenase