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Browse our Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteins (SRD5A2)

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Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteins (SRD5A2)
On www.antibodies-online.com are 4 Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Proteins from 2 different suppliers available. Additionally we are shipping Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antibodies (69) and Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Kits (22) and many more products for this protein. A total of 101 Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) products are currently listed.
Synonyms:
5ART2, S5AR 2, Srd5a2, SRD5alpha2
list all proteins Gene Name GeneID UniProt
SRD5A2 94224 Q99N99
SRD5A2 6716 P31213
Rat SRD5A2 SRD5A2 64677 P31214

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Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteins (SRD5A2) by Origin

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More Proteins for Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Interaction Partners

Mouse (Murine) Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) interaction partners

  1. observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes

  2. The induction of Srd5a2 through SREBP-2 (show SREBF2 Proteins) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.

Human Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) interaction partners

  1. Mutations in the SRD5A2 cause a disorder of 46,XY sex development, termed 5alpha-reductase type 2 deficiency. (Review)

  2. Meta-analysis of 20 publications incorporating 30 case-control studies indicated that the SRD5A2 rs9282858 polymorphism may be a susceptible factor to prostate cancer.

  3. Although 4-dione is the main source of 5alpha-dihydrotestosterone in human preadipocytes, production of this steroid by 5 alpha-reductase isoenzymes (SRD5A1 (show SRD5A1 Proteins), 2 and 3) mediates the inhibitory effect of both 4-dione and testosterone on preadipocyte differentiation.

  4. Mutations of the SRD5A2 gene is associated with 46, XY disorders of sex development.

  5. p.Ala65Pro mutation in the SRD5A2 gene causes 5alphaRD2 deficiency, especially in Turkey. V89L polymorphism may also be an important factor in the development of external genitalia

  6. deletion of exon 2 in the SRD5A2 gene causes various degrees of genital ambiguity leading to different sex of rearing in affected family members

  7. Mutations in SRD5A2 gene were found in 46, XY DSD (show FADS1 Proteins) children with pediatric hypospadias.

  8. Diagnosis of 5alpha-reductase 2 deficiency with assessment of the SRD5A2 gene may help in appropriate gender assignment.

  9. Results suggest that SRD5A2 controls cell migration by indirectly regulating ERK/MAPK (show MAPK1 Proteins) pathway in prostate cancer cells.

  10. Metabolic syndrome develops more frequently in testicular cancer survivors homozygous or heterozygous variant for SNP rs523349 in SRD5A2.

Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Protein Profile

Protein Summary

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).

Alternative names and synonyms associated with Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2)

  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (SRD5A2)
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (srd5a2)
  • steroid-5-alpha-reductase alpha polypeptide 2 (srd5a2)
  • steroid 5 alpha-reductase 2 (Srd5a2)
  • steroid 5-alpha-reductase 2 (ST5AR2)
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (Srd5a2)
  • 5ART2 protein
  • S5AR 2 protein
  • Srd5a2 protein
  • SRD5alpha2 protein

Protein level used designations for SRD5A2

3-oxo-5-alpha-steroid 4-dehydrogenase 2 , steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) , steroid-5-alpha-reductase alpha polypeptide 2 , 5 alpha-SR2 , SR type 2 , steroid 5 alpha reductase type2 , steroid 5-alpha-reductase 2 , S5AR 2 , type II 5-alpha reductase , prostatic steroid 5-alpha-reductase type II

GENE ID SPECIES
527024 Bos taurus
772291 Gallus gallus
549867 Xenopus (Silurana) tropicalis
705676 Macaca mulatta
100125532 Oryzias latipes
94224 Mus musculus
397048 Sus scrofa
6716 Homo sapiens
64677 Rattus norvegicus
403715 Canis lupus familiaris
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