Browse our PEX5 Proteins (PEX5)

Full name:
Peroxisomal Biogenesis Factor 5 Proteins (PEX5)
On www.antibodies-online.com are 5 Peroxisomal Biogenesis Factor 5 (PEX5) Proteins from 4 different suppliers available. Additionally we are shipping PEX5 Antibodies (43) and many more products for this protein. A total of 53 PEX5 products are currently listed.
Synonyms:
AW212715, ESTM1, PBD2A, PBD2B, Peroxin-5, PTS1-BP, PTS1R, PXR1, X83306
list all proteins Gene Name GeneID UniProt
PEX5 19305 O09012
PEX5 312703 Q2M2R8
PEX5 5830 P50542

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Mouse (Murine) Peroxisomal Biogenesis Factor 5 (PEX5) interaction partners

  1. monoubiquitination of the N-terminal cysteine of peroxisome-associated PEX5 not only functions to recycle the peroxin back to the cytosol, but also serves as a quality control mechanism to eliminate peroxisomes with a defective protein import machinery

  2. Demyelination in cerebellum and brain stem preceded major myelin loss in corpus callosum of Pex5 deficient mice.

  3. interaction of PEX5 with catalase (show CAT Proteins) and PEX14 (show PEX14 Proteins)

  4. Peroxisomes were selectively reconstituted in brain or liver of Pex5 knock-out mice, a model for Zellweger syndrome (show PEX1 Proteins), by tissue-selective overexpression of Pex5p. We found that both rescue strains exhibited a correction of the neuronal migration defect

Human Peroxisomal Biogenesis Factor 5 (PEX5) interaction partners

  1. data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 (show PEX14 Proteins) and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes.

  2. our data suggest that insertion of the trimeric PEX5-PEX7 (show PEX7 Proteins)-PTS2 protein complex into the DTM is probably accompanied by conformational alterations in PEX5 to allow release of the PTS2 protein into the organelle matrix

  3. Our data suggest that the functional polymorphism rs3814058C>T in 3'-UTR of PXR (show NR1I2 Proteins) may be a functional biomarker to predict risk of colorectal cancer

  4. PEX5 encodes two isoforms, PEX5L & PEX5S, & a homozygous frame shift mutation c.722dupA (p.Val242Glyfs( *)33), located in the PEX5L-specific exon 9, results in loss of PEX5L only. Loss of PEX5L results in deficient import of PTS2-tagged proteins

  5. bulky side chain within the recognition motif, which blocks contraction of the PEX5 binding cavity

  6. Data show that ataxia-telangiectasia mutated (ATM (show ATM Proteins)) phosphorylates peroxisomal biogenesis factor 5 (PEX5) at serine 141 in response to reactive oxygen species.

  7. ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulating PTS1 protein import

  8. PEX5 has a role in regulating peroxisome numbers by signaling to mediate pexophagy

  9. Cys11 in PEX5 serves as a functional redox switch regulating the peroxisomal/cytosolic localization of peroxisomal proteins.

  10. The novel Pex14 (show PEX14 Proteins)-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner.

PEX5 Protein Profile

Protein Summary

The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PEX5

  • peroxisomal biogenesis factor 5 (pex5)
  • peroxisomal biogenesis factor 5 (Pex5)
  • peroxisomal biogenesis factor 5 (PEX5)
  • AW212715 protein
  • ESTM1 protein
  • PBD2A protein
  • PBD2B protein
  • Peroxin-5 protein
  • PTS1-BP protein
  • PTS1R protein
  • PXR1 protein
  • X83306 protein

Protein level used designations for PEX5

peroxisome biogenesis factor 5 , PTS1 receptor , PTS1-BP , PXR1P , peroxin 5 , peroxisomal C-terminal targeting signal import receptor , peroxisomal targeting signal 1 receptor , peroxisome receptor 1 , peroxin-5 , peroxisomal targeting signal 1 (SKL type) receptor , peroxisomal targeting signal import receptor , peroxisomal targeting signal receptor 1 , PTS1R , Peroxisomal C-terminal targeting signal import receptor , Peroxisome receptor 1

GENE ID SPECIES
496849 Xenopus (Silurana) tropicalis
19305 Mus musculus
312703 Rattus norvegicus
5830 Homo sapiens
486710 Canis lupus familiaris
514832 Bos taurus
418299 Gallus gallus
100135597 Cavia porcellus
100689015 Cricetulus griseus
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