Browse our ATP2A2 Proteins (ATP2A2)

Full name:
ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 Proteins (ATP2A2)
On www.antibodies-online.com are 8 ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Proteins from 3 different suppliers available. Additionally we are shipping ATP2A2 Antibodies (59) and ATP2A2 Kits (8) and many more products for this protein. A total of 83 ATP2A2 products are currently listed.
Synonyms:
9530097L16Rik, ATP2, atp2a2, ATP2B, ca-p60a, D5Wsu150e, DAR, DD, mKIAA4195, Serca2, SERCA2A, SERCA2B, SercaII, zgc:55380
list all proteins Gene Name GeneID UniProt
ATP2A2 488 P16615
Rat ATP2A2 ATP2A2 29693 P11507
ATP2A2 11938 O55143

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ATP2A2 Proteins (ATP2A2) by Origin

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Top referenced ATP2A2 Proteins

  1. Human ATP2A2 Protein expressed in Wheat germ - ABIN1775707 : Ahmad, Shen, Vandeput, Szabo-Fresnais, Krall, Degerman, Goetz, Klussmann, Movsesian, Manganiello: Regulation of Sarcoplasmic Reticulum Ca2+ ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium: PHOSPHORYLATION-DEPENDENT INTERACTION OF PDE3A1 WITH SERCA2. in The Journal of biological chemistry 2015 (PubMed)

More Proteins for ATP2A2 Interaction Partners

Xenopus laevis ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. Atp2a2/serca2 is found in a larger subset of cells, but is not ubiquitous as reported in adults.

Horse (Equine) ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. the genomic organization and the equine ATP2A2 coding sequence and an association analysis for chronic pastern dermatitis using a sample of South German draft horses

Human ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. Results show that ATP2A2 is variably expressed in astrocytoma tissues and its expression correlates with tumor grade. Its overexpression suppresses growth of astrocytoma cells.

  2. study identifies a novel splice acceptor site mutation in the ATP2A2 gene, in a family showing Darier disease

  3. Data suggest that mutations of the sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) gene may lead to the occurrence of Darier disease (DD) in both familial and sporadic cases with DD.

  4. Phospholamban (show PLN Proteins) and sarcolipin are membrane proteins that differentially regulate SERCA (show ATP2A3 Proteins) function. (Review)

  5. CAPN3 (show CAPN3 Proteins) deficiency leads to degradation of SERCA (show ATP2A3 Proteins) proteins and Ca2 (show CA2 Proteins)+ dysregulation in the skeletal muscle.

  6. High SERCA2 expression is associated with colorectal cancer.

  7. Quantification of SERCA2 mRNA or protein expression levels revealed no differences in airway smooth muscle cells obtained from subjects with asthma compared to non-asthmatic controls.

  8. Inhibition of SERCA2 activity by curcumin disrupts the Ca(2 (show CA2 Proteins)+) homeostasis and thereby promotes apoptosis in ovarian cancer cells.

  9. The association between Darier disease and bipolar disorder is manifest also in the population, and data suggest that genetic variability within the ATP2A2 gene that causes Darier disease also confers susceptibility for bipolar disorder.

  10. ATP2A2 mutation was found in patients diagnosed with Darier disease.

Pig (Porcine) ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. Data suggest that the beneficial effects of SERCA2a gene transfer may involve the attenuation of ER stress-associated myocardial apoptosis.

  2. Oxidative/nitrosative stress associated with lung resection influences SERCA2a activity independent of any influence on protein expression or phospholamban (show PLN Proteins) phosphorylation.

  3. overexpression of SERCA2a by in vivo rAAV1-mediated intracoronary gene transfer preserved systolic function, potentially prevented diastolic dysfunction, and improved ventricular remodeling.

Rabbit ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. Data show that rabbit cold tolerance is probably related to increased muscle oxidative metabolism and heat production by SERCA1 (show ATP2A1 Proteins) and that these changes are not completely dependent on normal thyroid function.

  2. These results indicate a mechanism relating SERCA1 (show ATP2A1 Proteins) vicinal-cysteines oxidation to muscle fatigue.

Mouse (Murine) ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. Nevertheless, the functional role of protein serotonylation in controlling SAN automaticity is largely unexplored. In this study, we screened the cardiomyocytes proteins and found that sarco(endo)plasmic reticulum Ca ATPase type 2a (SERCA2a) can be serotonylated. Simulation studies using mathematical SAN cell model showed that variation of Ca(2 (show CA2 Proteins)+) affinity of SERCA2a pump cause either tachycardia or bradycardia.

  2. Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2 (show CA2 Proteins)+)storage and SERCA (show ATP2A3 Proteins) activity, ultimately affecting denervated skeletal muscle function.

  3. Generated were mice harboring N-ethyl-N-nitrosourea (ENU)-induced allelic mutations in Serca2: three missense mutations and one nonsense mutation. Mice harboring these Serca2 mutations developed tumors that were categorized as either early onset squamous cell tumors (SCT), with development similar to null-type knockout mice [2,4] (aggressive form; M682, M814), or late onset tumors (mild form; M1049, M1162).

  4. Identify Atrap as a novel regulatory protein of the cardiac Ca(2+)-ATPase SERCA2a. Suggest that Atrap enhances the activity of SERCA2a and, consequently, facilitates ventricular relaxation.

  5. CAPN3 (show CAPN3 Proteins) deficiency leads to degradation of SERCA (show ATP2A3 Proteins) proteins and Ca2 (show CA2 Proteins)+ dysregulation in the skeletal muscle.

  6. Sustained activation of Toll-like receptor 9 (show TLR9 Proteins) causes cardiac and systemic inflammation, and deterioration of SERCA2a depletion-mediated diastolic heart failure.

  7. The LRP1 (show LRP1 Proteins)/Pyk2 (show PTK2B Proteins) axis represses SERCA2 mRNA expression via HIF-1a (show HIF1A Proteins).

  8. This first-in-class small-molecule activator targeting SERCA2a SUMOylation may serve as a potential therapeutic strategy for treatment of heart failure

  9. privileged signal communication between the beta1-adrenergic receptor and SERCA2a impaired in cardiac hypertrophy

  10. These data reveal myofibrillar Ca(2 (show CA2 Proteins)+)-sensitivity to be an important determinant of the cardiac effects of SERCA2 haploinsufficiency and raise the possibility that Darier disease patients are more susceptible to heart failure under certain conditions.

Guinea Pig ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. SERCA2a gene transfer in the failing heart not only improves contractile function but also directly restores electric stability through amelioration of key arrhythmogenic substrate.

ATP2A2 Protein Profile

Protein Summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with ATP2A2

  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (atp2a2)
  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2)
  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2)
  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a (atp2a2a)
  • 9530097L16Rik protein
  • ATP2 protein
  • atp2a2 protein
  • ATP2B protein
  • ca-p60a protein
  • D5Wsu150e protein
  • DAR protein
  • DD protein
  • mKIAA4195 protein
  • Serca2 protein
  • SERCA2A protein
  • SERCA2B protein
  • SercaII protein
  • zgc:55380 protein

Protein level used designations for ATP2A2

Calcium ATPase at 60A , ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 , Atp2a2 , sarcoplasmic/endoplasmic reticulum calcium ATPase 2 , sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like , ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2 , SR Ca(2+)-ATPase 2 , calcium pump 2 , calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform , cardiac Ca2+ ATPase , endoplasmic reticulum class 1/2 Ca(2+) ATPase , SERCA2 , calcium ATPase , sarcoplasmic reticulum Ca2+-transport ATPase isoform , Ca(2+)-transport ATPase class 3 , sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2 , ATPase, Ca++ transporting, slow twitch 2 , sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2 , sarco/endoplasmic reticulum Ca2+-ATPase 2 , sarcoplasmic reticulum slow-twitch Ca2 ATPase , serca2

GENE ID SPECIES
380096 Xenopus laevis
452231 Pan troglodytes
540568 Bos taurus
791242 Equus caballus
100398261 Callithrix jacchus
100597073 Nomascus leucogenys
488 Homo sapiens
403878 Canis lupus familiaris
396875 Sus scrofa
100038308 Oryctolagus cuniculus
29693 Rattus norvegicus
11938 Mus musculus
100174978 Cavia porcellus
493691 Felis catus
396446 Gallus gallus
393940 Danio rerio
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