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Collectively, our data indicate that GABPA inhibits hepatocellular carcinoma cell migration and could serve as a novel biomarker for prognosis
CRISPR-mediated reversal of mutant TERT (show TERT ELISA Kits) promoters, or deletion of its long-range interacting chromatin, abrogates GABPA binding and long-range interactions, leading to depletion of active histone marks, loss of POL2 recruitment, and suppression of TERT (show TERT ELISA Kits) transcription
potential mechanism of TERT (show TERT ELISA Kits) reactivation mediated by a novel long-range chromatin interaction between the TERT (show TERT ELISA Kits) promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT (show TERT ELISA Kits) promoters but not in wild-type promoters.
a key role for GABPA/B1 as the critical ETS (show ETS1 ELISA Kits) transcription factors deregulating SDHD (show SDHD ELISA Kits) expression in the context of highly recurrent promoter mutations in melanoma.
Analyses of data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF), and human-specific genes.
ELF1 (show EFNA2 ELISA Kits) binding occurs at both TERT (show TERT ELISA Kits) promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS (show ETS1 ELISA Kits) motifs in the TERT (show TERT ELISA Kits) promoter region.
The results suggest that NRF-2alpha is a regulator of SIRT3 (show SIRT3 ELISA Kits) expression and may shed light on how SIRT3 (show SIRT3 ELISA Kits) is upregulated during nutrient stress.
GABPalpha Binding to Overlapping ETS (show ETS1 ELISA Kits) and CRE DNA Motifs Is Enhanced by CREB1 (show CREB1 ELISA Kits)
Expression of the ETS transcription factor (show FEV ELISA Kits) GABPalpha is positively correlated to the BCR (show BCR ELISA Kits)-ABL1/ABL1 (show ABL1 ELISA Kits) ratio in CML (show BCR ELISA Kits) patients and affects imatinib sensitivity in vitro.
study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b (show ITGAM ELISA Kits) as a novel GABP target gene
conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression
Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL (show ABL1 ELISA Kits)-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.
NRF-2 (show NFE2L2 ELISA Kits) and NRF-1 (show NRF1 ELISA Kits) operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx (show ZFX ELISA Kits) and Etv6 (show ETV6 ELISA Kits) transcription factors and prosurvival Bcl-2 (show BCL2 ELISA Kits) family members including Bcl-2 (show BCL2 ELISA Kits), Bcl-X(L (show BCL2L1 ELISA Kits)), and Mcl-1 (show MCL1 ELISA Kits) as direct GABP target genes.
Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.
chemical shift and secondary structure of the PNT (show ETS2 ELISA Kits)/SAM (show TTN ELISA Kits) domains
Erralpha (show ESRRA ELISA Kits) and GA-binding protein a partner with PGC-1alpha (show PPARGC1A ELISA Kits) in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes
Gabpa function is essential and is not compensated for by other ETS (show ETS1 ELISA Kits) transcription factors and is consistent with a specific requirement for Gabp expression for the maintenance of target genes involved in embryo essential mitochondrial cellular functions
GABP is essential for the regulation of IL-7Ralpha (show IL7R ELISA Kits) expression in T cells.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
GA binding protein transcription factor, alpha subunit 60kDa
, transcription factor GABP alpha subunit
, GA binding protein transcription factor, alpha subunit (60kD)
, GA-binding protein alpha chain-like
, GA repeat binding protein, alpha
, GA-binding protein alpha chain
, nuclear respiratory factor 2 alpha
, GA binding protein transcription factor alpha subunit 60kDa
, GABP subunit alpha
, human nuclear respiratory factor-2 subunit alpha
, nuclear respiratory factor 2 alpha subunit
, nuclear respiratory factor 2 subunit alpha
, transcription factor E4TF1-60
, GA repeat binding protein alpha
, GA-binding protein alpha-subunit
, E4tf1-60 transcription factor