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Human GABPA Protein expressed in Wheat germ - ABIN1354635
Makowski, Willems, Fang, Choi, Zhang, Jansen, Brown, Vermeulen: An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations. in Proteomics 2016
a key role for GABPA/B1 as the critical ETS (show ETS1 Proteins) transcription factors deregulating SDHD (show SDHD Proteins) expression in the context of highly recurrent promoter mutations in melanoma.
Analyses of data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF), and human-specific genes.
ELF1 (show EFNA2 Proteins) binding occurs at both TERT (show TERT Proteins) promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS (show ETS1 Proteins) motifs in the TERT (show TERT Proteins) promoter region.
The results suggest that NRF-2alpha is a regulator of SIRT3 (show SIRT3 Proteins) expression and may shed light on how SIRT3 (show SIRT3 Proteins) is upregulated during nutrient stress.
GABPalpha Binding to Overlapping ETS (show ETS1 Proteins) and CRE DNA Motifs Is Enhanced by CREB1 (show CREB1 Proteins)
Expression of the ETS transcription factor (show FEV Proteins) GABPalpha is positively correlated to the BCR (show BCR Proteins)-ABL1/ABL1 (show ABL1 Proteins) ratio in CML (show BCR Proteins) patients and affects imatinib sensitivity in vitro.
study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b (show ITGAM Proteins) as a novel GABP target gene
GABPA thus directly links TERT (show TERT Proteins) promoter mutations to aberrant expression in multiple cancers.
GABPA exhibits an increase in binding signal with higher numbers of ETS (show ETS1 Proteins) motifs per promoter. Analysis of the distance between inverted pairs of ETS (show ETS1 Proteins) motifs within promoters and binding by p53 (show TP53 Proteins), ETS1 (show ETS1 Proteins) and GABPA, shows a coordination of binding for the 3.
results demonstrate the functional importance of the C/EBPalpha (show CEBPA Proteins) C-terminus beyond the bZIP DNA-binding and dimerization region, which may mediate cooperative activation by C/EBPalpha (show CEBPA Proteins) and GABP of myeloid-specific genes
conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression
Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL (show ABL1 Proteins)-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.
NRF-2 (show NFE2L2 Proteins) and NRF-1 (show NRF1 Proteins) operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx (show ZFX Proteins) and Etv6 (show ETV6 Proteins) transcription factors and prosurvival Bcl-2 (show BCL2 Proteins) family members including Bcl-2 (show BCL2 Proteins), Bcl-X(L (show BCL2L1 Proteins)), and Mcl-1 (show MCL1 Proteins) as direct GABP target genes.
Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.
chemical shift and secondary structure of the PNT (show ETS2 Proteins)/SAM (show TTN Proteins) domains
Erralpha and GA-binding protein a partner with PGC-1alpha in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes
Gabpa function is essential and is not compensated for by other ETS (show ETS1 Proteins) transcription factors and is consistent with a specific requirement for Gabp expression for the maintenance of target genes involved in embryo essential mitochondrial cellular functions
GABP is essential for the regulation of IL-7Ralpha (show IL7R Proteins) expression in T cells.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
GA binding protein transcription factor, alpha subunit 60kDa
, transcription factor GABP alpha subunit
, GA binding protein transcription factor, alpha subunit (60kD)
, GA-binding protein alpha chain-like
, GA repeat binding protein, alpha
, GA-binding protein alpha chain
, nuclear respiratory factor 2 alpha
, GA binding protein transcription factor alpha subunit 60kDa
, GABP subunit alpha
, human nuclear respiratory factor-2 subunit alpha
, nuclear respiratory factor 2 alpha subunit
, nuclear respiratory factor 2 subunit alpha
, transcription factor E4TF1-60
, GA repeat binding protein alpha
, GA-binding protein alpha-subunit
, E4tf1-60 transcription factor