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RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal.
RGS19 may play an important role in controlling the degree of synergism between FGF-1 (show FGF1 Proteins) receptors and 5-HT1A (show HTR1A Proteins) receptors, that may work together to mediate an anti-depressant effect.
Overall methylation levels in the promoter regions of three genes (ALDH1A1 (show ALDH1A1 Proteins), OPRL1 (show OPRL1 Proteins) and RGS19) are elevated in subjects who were exposed to childhood adversity.
The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein (show HOMER1 Proteins) KSR1 (show KSR1 Proteins) and a nucleoside diphosphate kinase Nm23 (show NME1 Proteins).
elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases
cyclin D1 (show CCND1 Proteins)/3 and Cdk6 (show CDK6 Proteins) were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B (show CDKN2B Proteins) were reduced
GIPC (show GIPC1 Proteins) recruits GAIP (RGS19) to attenuate dopamine D2 receptor (show DRD2 Proteins) signaling
Our findings provide insight for the first time into the mechanisms involved in Rgs19 regulation of mouse ESC proliferation and differentiation.
Notch (show NOTCH1 Proteins) signaling positively regulates phosphorylation of Akt (show AKT1 Proteins), possibly via phosphorylation of RGS19
RGS19 and its partner Galpha (show SUCLG1 Proteins)-inhibiting activity polypeptide 3 (GNAI3 (show GNAI3 Proteins)) are involved in zVAD-, but not TNF (show TNF Proteins)-, induced cell death.
level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3 (show GNAI3 Proteins), AGS3 (show GPSM1 Proteins), or RGS19; or had been treated with pertussis toxin, were similar to controls
Rgs19 plays important roles in palatal fusion.
Regulator of G protein signaling 19 enhances cell proliferation through binding to GAIP-interacting protein C (show PROC Proteins)-terminus.
RGS19 influenced cardiac development and had negative effects on heart function.
RGS19 prefers regulating ORL1 (show OPRL1 Proteins) receptor signaling over other opioid receptors, and the N-terminal domain of RGS19 plays a crucial role in its receptor preference
Results suggest a complex role for RGS19 in regulating the ability of Wnt3a (show WNT3A Proteins) to signal to the level of beta-catenin (show CTNNB1 Proteins) and gene transcription.
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
regulator of G-protein signaling 19
, regulator of G-protein signalling 19
, G alpha interacting protein
, G protein signalling regulator 19
, G-alpha-interacting protein
, guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
, G-alpha interacting protein
, calcium/calmodulin-dependent protein kinase I