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CaSR (show CASR Proteins) exerts a suppressive function in pancreatic tumorigenesis through a novel NCX1/Ca(2 (show CA2 Proteins)+)/beta-catenin (show CTNNB1 Proteins) signaling pathway.
Palmitoylation of cardiac NCX1 can modify its function, physical interactions, and removal from the sarcolemma by domain-dependent endocytosis.
NCX1 and the calcium binding protein (show CETN1 Proteins) calretinin (show CALB2 Proteins) cooperate within the striatum to confer tolerance against cerebral ischemia.
ADD2 (show ADD2 Proteins) and NCX1 variants influence the risk and the clinical features of systemic lupus erythematosus and lupus nephritis.
NCX1 operating in reverse mode plays a prominent role in calcium cytosolic regulation in highly metastatic melanoma cells.
The expression of miR (show MLXIP Proteins)-206 by HUVECs reduced exosome production by regulating ADP-Ribosylation Factor 6 (ARF6 (show ARF6 Proteins)) and sodium/calcium exchanger 1 (NCX1).
interaction of NHE1 (show SLC9A1 Proteins), NCX1 and CaM (show CALM1 Proteins) mediates the effects of IL6 (show IL6 Proteins) on human hepatocellular carcinoma
NCX1.3 is the predominant NCX (show TLX2 Proteins) variant in the distal convoluted and connecting tubules tubules
results demonstrate that CaM (show CALM1 Proteins) senses changes in [Ca2 (show CA2 Proteins)+]i and binds to the cytoplasmic loop of NCX1 to regulate exchange activity.
The expressions of NCX1 and NCKX4 (show Slc24a4 Proteins) were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels.
The SOCE/Cl(Ca) interaction does not require reverse-mode Na+/Ca2 (show CA2 Proteins)+ exchange in our conditions.
There were substantial transmural gradients in Cav1.2, KChIP2, ERG, KvLQT1, Kir2.1, NCX1, SERCA2a and RyR2 at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.
NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.
Induced overexpression of NCX1 attenuated pressure overload-induced pathological cardiac remodelling
The heterogeneous expression of multiple types of Na(+)/Ca(2 (show CA2 Proteins)+) exchangers and the quantitative differences found in calcium concentration, together with other risk factors specific to dopaminergic neurons such as dopamine oxidation resulting in oxidative stress, may drive these cells to undergo selective degeneration.
NCX1 is dispensable for osteoclast differentiation.
the functional role of NCX on gastrointestinal motility
These results suggested that NCX1 may play an important role in the proper spatial distribution of LTCC and JP2 (show JPH2 Proteins) in T-tubules in the context of pressure-overloading.
In this study, authors demonstrate that NCX1 regulates gastric fundus motility.
NCX1 and NCX2 play important roles in ileal motility and suggest that NCX1 and NCX2 regulate the motility in the ileum by controlling the sensitivity of smooth muscles to ACh (show FGFR3 Proteins) and SP.
Data show that transforming growth factor beta1 (TGFbeta1 (show TGFB1 Proteins)) is a powerful stimulator of both, store operated Ca2 (show CA2 Proteins)+ entry (SOCE) and Na+/Ca2+-exchanger activity in megakaryocytes.
dobutamine upregulates of voltage-gated Na+ channel function and Na+ influx-induced activation of the reverse mode of NCX
JAK3 (show JAK3 Proteins) deficiency is followed by down-regulation of cytosolic Ca(2 (show CA2 Proteins)+) release, receptor and store operated Ca(2 (show CA2 Proteins)+) entry and Na(+)/Ca(2 (show CA2 Proteins)+) exchanger activity in dendritic cells.
These results indicate that, for a proper MgATP up-regulation of NCX1, the enzyme responsible for PtdIns-4,5P2 synthesis must be (i) functionally competent and (ii) set in the NCX1 microenvironment closely associated to the exchanger.
The cleavage of NCX1 by m-calpain (show CAPN2 Proteins) in the caveolae vesicles may be interpreted as an important mechanism of Ca(2 (show CA2 Proteins)+) overload
a novel mechanism for the regulation of NCX1 activity
Na/Ca exchanger's (NCX1) associates specifically with caveolin-3 (show CAV3 Proteins)(NCX1)(caveolin-3 (show CAV3 Proteins))
the regulation of phosphatidylinositol-4,5-biphosphate binding to the bovine cardiac Na+/Ca2+ exchanger(NCX1)
Data suggest that peroxynitrite leads to calcium (Ca2 (show CA2 Proteins)+) uptake through stimulation of Ca2+-ATPase, but inhibits Ca2 (show CA2 Proteins)+ uptake through inhibition of the sodium-Ca2 (show CA2 Proteins)+ exchanger, resulting in decreased overall Ca2 (show CA2 Proteins)+ uptake in smooth muscle microsomes.
These data suggest a role for the reverse mode of the NCX in refilling the sarcoplasmic reticulum in airway smooth muscle following Ca(2 (show CA2 Proteins)+) mobilization.
Cleavage of NCX may be interpreted as the main cause of Ca(2 (show CA2 Proteins)+) overload and could lay a key role in activation of apoptotic processes in pulmonary smooth muscle.
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
solute carrier family 8 (sodium/calcium exchanger), member 1
, sodium/calcium exchanger 1
, sodium calcium exchanger 1n
, sodium/calcium exchanger 1-like
, Na(+)/Ca(2+)-exchange protein 1
, Na+/Ca++ exchanger
, Na+/Ca2+ exchanger
, sodium/calcium exchanger
, solute carrier family 8 member 1
, Na/Ca exchanger
, Na-Ca exchanger
, solute carrier family 8, member 1
, sodium-calcium exchanger
, sodium/calcium exchanger isoform NaCa13
, sodium/calcium exchanger isoform NaCa3
, sodium/calcium exchanger isoform NaCa9
, sodium/calcium exchanger isoform NaCa7
, T-cell leukemia homeobox protein 2
, T-cell leukemia, homeobox 2
, enteric neuron homeobox protein
, homeo box 11-like 1
, homeobox TLX-2
, homeobox protein Hox-11L1