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Browse our ABCC8 Proteins (ABCC8)

Full name:
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 Proteins (ABCC8)
On www.antibodies-online.com are 7 ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Proteins from 4 different suppliers available. Additionally we are shipping ABCC8 Antibodies (84) and ABCC8 Kits (2) and many more products for this protein. A total of 97 ABCC8 products are currently listed.
Synonyms:
ABC36, D930031B21Rik, HHF1, HI, HRINS, MRP8, PHHI, Sur, Sur1, SUR1delta2, TNDM2
list all proteins Gene Name GeneID UniProt
ABCC8 6833 Q09428
Mouse ABCC8 ABCC8 20927  
Rat ABCC8 ABCC8 25559 Q09429

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ABCC8 Proteins (ABCC8) by Origin

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More Proteins for ABCC8 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. ABCC8 mutation is associated with neonatal diabetes mellitus and iDEND syndrome.

  2. The most frequently seen mutations in Turkish patients with congenital hyperinsulinism (CHI) were ATP binding cassette subfamily C member 8 (ABCC8) gene, followed by 3-hydroxyacyl CoA dehydrogenase (HADH (show HADH Proteins)) and kcnj11 (show KCNJ11 Proteins) channel (KCNJ11 (show KCNJ11 Proteins)) genes.

  3. Mutations in the ABCC8 gene were the most common cause of congenital hyperinsulinism in our cohort.

  4. ABCC8 mutation is associated with persistently elevated insulin (show INS Proteins) concentrations.

  5. A study of mutations in the ABCC8 gene that cause congenital hyperinsulinism demonstrate a clear functional distinction between SUR1 nucleotide-binding domain two (NBD2) and transmembrane domain (TMD (show TTN Proteins)) mutants

  6. up-regulation of SUR1 in humans point to this channel as one of the important molecular players in the pathophysiology of Post-traumatic brain contusions

  7. HNF1A (show HNF1A Proteins) gene mutations represented the second most frequent genetic cause of congenital hyperinsulinism of infancy in the Czech Republic

  8. single amino acid difference can account for the markedly different diazoxide sensitivities between channels containing either the SUR1 or SUR2A (show ABCC9 Proteins) subunit isoforms.

  9. Mutations in ABCC8 are associated with neonatal diabetes mellitus.

  10. First description of a homozygous p.R1419H mutation in ABCC8 in a family leading to postprandial hyperglycemia followed by hypoglycemia.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. study provides evidence for a role of Abcc8(ATP-binding cassette sub-family C) in early-phase glucose-mediated insulin (show INS Proteins) secretion and validates this gene as a contributor to beta-cell dysfunction in type 2 diabetes

  2. We conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin (show INS Proteins) secretion due a failure of insulin (show INS Proteins) content to increase with age.

  3. The results confirm that Kir6.2 (show KCNJ11 Proteins) contributes to APD shortening in both atria and ventricle during metabolic stress, and that SUR1 is required for atrial APD shortening while SUR2A (show ABCC9 Proteins) is required for ventricular APD shortening.

  4. EPAC (show RAPGEF3 Proteins) interaction with SUR1 controls seizure susceptibility and possibly acts via regulation of glutamate (show GRIN1 Proteins) release.

  5. the role of CpG methylation in regulating SUR1 and SUR2 (show ABCC9 Proteins) expression

  6. SUR1 controls K(ATP) channel activity but not TRPM4 (show TRPM4 Proteins) channels.

  7. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC (show ABCB6 Proteins)) transporters ABCB6 (show ABCB6 Proteins) and sulfonylurea receptor 1 (SUR1)/ABCC8.

  8. ATP regulates pancreatic beta-cell K(ATP) channel activity, not only by its direct actions on Kir6.2 pore subunit, but also via ATP modulation of Syn-1A binding to SUR1.

  9. Diazoxide does not open the ventricular sarcolemmal adenosine triphosphate-sensitive potassium channel but provides volume homeostasis via an SUR1-dependent pathway in mouse ventricular myocytes.

  10. The role of Abcc8, which encodes sulfonylurea receptor 1 (SUR1), was assessed in progressive hemorrhagic necrosis.

Pig (Porcine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (show KCNAB2 Proteins) (Kir6.2 (show KCNJ11 Proteins), associated with Sur1), glucagon-like peptide 1 receptor (GLP1R (show GLP1R Proteins)), and adrenergic receptor alpha 2A (show ADRA2A Proteins) (ADRalpha2A)

ABCC8 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed\; however, the transcript variants have not been fully described.

Alternative names and synonyms associated with ABCC8

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC8)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (Abcc8)
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 8 (Abcc8)
  • ABC36 protein
  • D930031B21Rik protein
  • HHF1 protein
  • HI protein
  • HRINS protein
  • MRP8 protein
  • PHHI protein
  • Sur protein
  • Sur1 protein
  • SUR1delta2 protein
  • TNDM2 protein

Protein level used designations for ABCC8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8 , ATP-binding cassette, sub-family C, member 8 , ATP-binding cassette sub-family C member 8 , ATP-binding cassette transporter sub-family C member 8 , sulfonylurea receptor (hyperinsulinemia) , sulfonylurea receptor 1 , sulfonylurea receptor , sulphonylurea receptor 1

GENE ID SPECIES
423072 Gallus gallus
451056 Pan troglodytes
654490 Macaca mulatta
6833 Homo sapiens
20927 Mus musculus
485402 Canis lupus familiaris
538996 Bos taurus
100158245 Sus scrofa
100722700 Cavia porcellus
25559 Rattus norvegicus
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