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ADD1 rs4963 polymorphism showed an increased hypertension risk.
This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.
Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC (show CALR Proteins)) suggesting an association between ADD1 and CRC (show CALR Proteins) risk.
The T allele of ADD1 is associated with essential hypertension in Asians.
study of potential effects of interaction between DNA methylation (show HELLS Proteins) of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation (show HELLS Proteins) of ADD1 gene promoter have a significant role in modifying EH susceptibility
There were significant differences between the control group and pediatric hypertensive group in terms of ACE (show ACE Proteins) I/D (P<0.05) and AGT (show AGXT Proteins) M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
When alpha-adducin complexes with sodium potassium ATPase in astrocytes, non-cell autonomous neurodegeneration is triggered.
Phosphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin-X (Myo10).
Fnnctional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer.
adducin activity is not essential for actin ring assembly and periodicity but is necessary to control the diameter of both actin rings and axons and actin filament growth within rings.
observations suggest that MALAT1 promotes hepatic steatosis and insulin (show INS Proteins) resistance by increasing nuclear SREBP-1c (show SREBF1 Proteins) protein stability.
Advanced glycation end products overproduction in mice liver and skeletal muscle is associated to increased lipogenesis due to the activation of SREBP-1c (show SREBF1 Proteins).
Srebp-1 (show SREBF1 Proteins) interacts with c-Myc (show MYC Proteins), facilitates its binding to downstream pluripotent targets.
SREBP1a or -1c could be acting as transcriptional repressors for rarg2 and when srebf1a expression is down-regulated, its repressing activity disappears.
SREBP-2 (show SREBF2 Proteins) is critical for survival and limb patterning during development
The two cereal dietary fibers potently decreased protein expressions of sterol regulatory element binding protein-1 (show SREBF1 Proteins) and key factors involved in lipogenesis
SREBP-1 (show SREBF1 Proteins) acts as a positive regulator of Sfrp2 (show SFRP2 Proteins) transcription in chondrogenic cells.
regulatory mechanism by which insulin (show INS Proteins) inhibits cardiac UCP3 expression through activation of the lipogenic factor SREBP-1 (show SREBF1 Proteins).
Taken together, our results suggest that an NCE-box within the clusterin (show CLU Proteins) promoter is necessary for insulin (show INS Proteins)-stimulated hepatic expression of clusterin (show CLU Proteins) via SREBP-1c (show SREBF1 Proteins).
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms\; however, not all variants have been fully described.
adducin 1 (alpha)
, adducin 2 (beta)
, erythrocyte adducin alpha subunit
, erythrocyte adducin subunit alpha
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element-binding protein 1