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Browse our ARHGEF12 Proteins (ARHGEF12)

Full name:
rho Guanine Nucleotide Exchange Factor (GEF) 12 Proteins (ARHGEF12)
On www.antibodies-online.com are 3 rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12) Proteins from 2 different suppliers available. Additionally we are shipping ARHGEF12 Antibodies (30) and many more products for this protein. A total of 34 ARHGEF12 products are currently listed.
Synonyms:
2310014B11Rik, ARHGEF12, AU019857, LARG, mKIAA0382, PRO2792
list all proteins Gene Name GeneID UniProt
ARHGEF12 23365 Q9NZN5
ARHGEF12 69632  
Rat ARHGEF12 ARHGEF12 367072  

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ARHGEF12 Proteins (ARHGEF12) by Origin

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More Proteins for ARHGEF12 Interaction Partners

Xenopus laevis rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12) interaction partners

Human rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12) interaction partners

  1. that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1 (show CDK1 Proteins)

  2. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF (show ARHGEF11 Proteins) and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.

  3. this study identified a novel association between IOP and ARHGEF12.

  4. TGF-beta (show TGFB1 Proteins) regulates LARG and GEF-H1 (show ARHGEF2 Proteins) during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.

  5. LARG is a novel and temporally distinct Rho Guanine Nucleotide Exchange Factor required for completion of abscission.

  6. Data indicate that ICAM-1 (show ICAM1 Proteins) signaling activates leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as Rho GEF (show SLC2A4RG Proteins) 12 (ARHGEF12).

  7. Agonist-induced Ca2 (show CA2 Proteins)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.

  8. RhoGEF (show ARHGEF11 Proteins) activity of p210 BCR/ABL (show ABL1 Proteins) directly contributes to transforming activity, and may account for the difference in disease outcome associated with p190 (show CNTNAP1 Proteins) BCR/ABL (show ABL1 Proteins) and p210 BCR/ABL (show ABL1 Proteins).

  9. NIS enhanced cell migration and invasion by binding to leukemia-associated RhoA (show RHOA Proteins) guanine exchange factor

  10. The PDZ domain of LARG is required HRH1 (show DHX8 Proteins)-mediated activation of the strictly Rho-dependent transcriptional activity of serum response factor and can be mimicked by activated Galpha(q (show GNAQ Proteins))(Q209L).

Mouse (Murine) rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12) interaction partners

  1. LARG may play a housekeeper role in regulating constitutive RhoA (show RHOA Proteins) activity. Its role in regulating platelet function may principally be through RhoA (show RHOA Proteins)-independent pathways.

  2. The increase in LARG expression was accompanied by a significant increase in ACh (show FGFR3 Proteins)-stimulated Rho kinase (show ROCK2 Proteins) and ZIP kinase (show DAPK3 Proteins) activities, and sustained muscle contraction

  3. Agonist-induced Ca2 (show CA2 Proteins)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.

  4. PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.

  5. LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras

  6. new insight into the mechanism by which p115RhoGEF (show ARHGEF1 Proteins) is activated by Galpha (show SUCLG1 Proteins)(13).

  7. S1PR2 (show S1PR2 Proteins)-dependent activation of RhoA (show RHOA Proteins) in smooth muscle cells is mediated by LARG and that this signaling mechanism promotes the differentiated SMC (show DYM Proteins) phenotype.

  8. Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q (show GNAQ Proteins)-coupled activation of RhoA (show RHOA Proteins) (larg protein)

  9. We demonstrate colocalization of the LARG protein with the IGF-1 (show IGF1 Proteins) receptor, suggesting a potential physiologic role for LARG as an activator of RhoA (show RHOA Proteins) in response to IGF-1 (show IGF1 Proteins).

  10. mLARG is highly expressed in hematopoietic stem cell fractions, as well as in immature erythroid cells, and provide further support to the hypothesis of the potential involvement of LARG in regulation of early stages of hematopoiesis.

Cow (Bovine) rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12) interaction partners

  1. cDNA of LARG (leukemia-associated guanine nucleotide exchange factor) was identified, and its gene expression was observed to be downregulated under clinorotation, which subsequently resulted in the repression of RhoA (show RHOA Proteins) activation

ARHGEF12 Protein Profile

Protein Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with ARHGEF12

  • Rho guanine nucleotide exchange factor (GEF) 12 (arhgef12)
  • Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12)
  • Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12)
  • 2310014B11Rik protein
  • ARHGEF12 protein
  • AU019857 protein
  • LARG protein
  • mKIAA0382 protein
  • PRO2792 protein

Protein level used designations for ARHGEF12

guanine nucleotide exchange factor , Rho guanine nucleotide exchange factor (GEF) 12 , rho guanine nucleotide exchange factor 12-like , leukemia-associated RhoGEF , leukemia-associated rho guanine nucleotide exchange factor , rho guanine nucleotide exchange factor 12 , leukemia-associated Rho guanine-nucleotide exchange factor , leukemia-associated Rho guanine nucleotide exchange factor

GENE ID SPECIES
398710 Xenopus laevis
419752 Gallus gallus
451618 Pan troglodytes
479409 Canis lupus familiaris
712096 Macaca mulatta
779951 Xenopus (Silurana) tropicalis
100030904 Monodelphis domestica
100457621 Pongo abelii
100471078 Ailuropoda melanoleuca
100523324 Sus scrofa
100548723 Meleagris gallopavo
100602658 Nomascus leucogenys
23365 Homo sapiens
69632 Mus musculus
367072 Rattus norvegicus
503575 Bos taurus
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