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anti-Mouse (Murine) rala Antibodies:
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Human Polyclonal rala Primary Antibody for IHC, WB - ABIN350787
Cantor, Urano, Feig: Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. in Molecular and cellular biology 1995
Show all 9 references for ABIN350787
Chicken Monoclonal rala Primary Antibody for IHC (f), IF - ABIN967835
Goi, Rusanescu, Urano, Feig: Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. in Molecular and cellular biology 1999
Show all 5 references for ABIN967835
striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB (show Ralb Antibodies).
RalA activation was remarkably impaired in rac1-deficient skeletal muscle fibres.
Our results provide the first in vivo characterization of RalA function in the mammalian brain and highlight a novel molecular mechanism for cell polarization.
The constitutively increased RalA activity occludes further increases in RalA activity during induction of long-term depression, causing impaired NMDAR (show GRIN1 Antibodies)-long-term depression.
findings show either RALA or RALB (show Ralb Antibodies) is sufficient for tumor growth; either RALA or RALB (show Ralb Antibodies) is sufficient for cell proliferation; RALA and RALB (show Ralb Antibodies) act in a redundant fashion
study reports the identification and characterization of a Ral GAP complex (RG1 (show PPP1R3A Antibodies), RGC2 (show RALGAPA2 Antibodies)) that mediates the activation of RalA downstream of the PI 3 (show PI3 Antibodies)-kinase/Akt (show AKT1 Antibodies) pathway
A novel regulatory pathway involves RalA and phospholipase D (show PLD Antibodies) in the production of phosphatidic acid during Fc gamma receptor (show FCGR1A Antibodies)-mediated phagocytosis and phagosome formation.
RalA but not RalB (show Ralb Antibodies) mediates integrin-dependent membrane raft exocytosis through the exocyst complex. Constitutively active RalA restores membrane raft targeting to promote anchorage-independent growth signaling.
RalA activation elicited by the exchange factor RalGDS (show RALGDS Antibodies) in response to a rise in intracellular Ca2 (show CA2 Antibodies)+ and cAMP controls hormone release from pancreatic beta-cells
RalA is activated by H-Ras (show HRAS Antibodies), which along with ARF6 (show ARF6 Antibodies), leads to phospholipase D (show PLD Antibodies) activation
agonist-induced Gbetagamma-mediated conversion of RalA from the GTP (show AK3 Antibodies)-bound form to the GDP-bound form could be a mechanism to facilitate agonist-induced internalization of GPCRs.
RCC2 (show RCC2 Antibodies) exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase (show RACGAP1 Antibodies) RalA. RCC2 (show RCC2 Antibodies) and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis.
expression of K-Ras (show HRAS Antibodies) and RalB (show Ralb Antibodies) and possibly RalA proteins is critical for maintaining low levels of p53 (show TP53 Antibodies), and down-regulation of these GTPases reactivates p53 (show TP53 Antibodies) by significantly enhancing its stability, contributing to suppression of malignant transformation
These results indicate that MLN8237 treatment may be effective for a subset of patients with PDAC independent of RalA S194 phosphorylation
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 (show SOX9 Antibodies) and ACAN (show ACAN Antibodies).
Data show that small GTPase (show RACGAP1 Antibodies) RALA regulates formation of a JIP1 (show MAPK8IP1 Antibodies) (C-Jun (show JUN Antibodies)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (show MAPK8 Antibodies) signaling toward FOXO4 (show FOXO4 Antibodies) (forkhead box O (show FOXO Antibodies) transcription factor) in response to reactive oxygen species (ROS (show ROS1 Antibodies)).
RalA and RalB (show Ralb Antibodies) exhibit both distinct and redundant roles in tumorigenesis (Review).
Targeted interference of EP2 (show SPAG11B Antibodies)/EP4 (show PTGER4 Antibodies) signal to RalA.GTP may provide benefit to patients diagnosed with advanced kidney cancer.
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
RAS-like, family 1
, ral-A protein
, ras-related protein Ral-A
, -ral simian leukemia viral oncogene homolog A (ras related)
, RAS-like protein A
, Ras family small GTP binding protein RALA
, ras related v-ral simian leukemia viral oncogene homolog A