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anti-Mouse (Murine) rala Antibodies:
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Chicken Monoclonal rala Primary Antibody for IHC (f), IF - ABIN967836
Goi, Rusanescu, Urano, Feig: Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. in Molecular and cellular biology 1999
Show all 5 Pubmed References
Chicken Monoclonal rala Primary Antibody for IHC (f), IF - ABIN967835
Kinashi, Katagiri, Watanabe, Vanhaesebroeck, Downward, Takatsu: Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras. in The Journal of biological chemistry 2000
Show all 5 Pubmed References
This study identifies a novel regulatory crosstalk between Ral and Arf6 (show ARF6 Antibodies) that controls Ral function in cells.
striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB (show Ralb Antibodies).
RalA activation was remarkably impaired in rac1-deficient skeletal muscle fibres.
Our results provide the first in vivo characterization of RalA function in the mammalian brain and highlight a novel molecular mechanism for cell polarization.
The constitutively increased RalA activity occludes further increases in RalA activity during induction of long-term depression, causing impaired NMDAR (show GRIN1 Antibodies)-long-term depression.
findings show either RALA or RALB (show Ralb Antibodies) is sufficient for tumor growth; either RALA or RALB (show Ralb Antibodies) is sufficient for cell proliferation; RALA and RALB (show Ralb Antibodies) act in a redundant fashion
study reports the identification and characterization of a Ral GAP complex (RG1 (show PPP1R3A Antibodies), RGC2 (show RALGAPA2 Antibodies)) that mediates the activation of RalA downstream of the PI 3 (show PI3 Antibodies)-kinase/Akt (show AKT1 Antibodies) pathway
A novel regulatory pathway involves RalA and phospholipase D (show PLD Antibodies) in the production of phosphatidic acid during Fc gamma receptor (show FCGR1A Antibodies)-mediated phagocytosis and phagosome formation.
RalA but not RalB (show Ralb Antibodies) mediates integrin-dependent membrane raft exocytosis through the exocyst complex. Constitutively active RalA restores membrane raft targeting to promote anchorage-independent growth signaling.
RalA activation elicited by the exchange factor RalGDS (show RALGDS Antibodies) in response to a rise in intracellular Ca2 (show CA2 Antibodies)+ and cAMP controls hormone release from pancreatic beta-cells
This study demonstrated that RalA is overactivated in medulloblastoma.
Study shows the additional benefits of anti-RalA autoantibody as a potential serological biomarker for prostate cancer (PCa (show FLVCR1 Antibodies)), particularly in patients with normal PSA (show PLAG1 Antibodies), and further demonstrate the utility of biomarker combinations in the immunodiagnosis of PCa (show FLVCR1 Antibodies).
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of the D2R and D3R, through GRK2 and beta-arrestins, respectively. Active RalA was found to interact with GRK2 to sequester it from D2R. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
results suggest that the small GTPase (show RACGAP1 Antibodies) RalA plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (show CAV1 Antibodies) and FilA but by stimulating PLD2 (show PLD2 Antibodies)-mediated generation of phosphatidic acid.
agonist-induced Gbetagamma-mediated conversion of RalA from the GTP (show AK3 Antibodies)-bound form to the GDP-bound form could be a mechanism to facilitate agonist-induced internalization of GPCRs.
RCC2 (show RCC2 Antibodies) exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase (show RACGAP1 Antibodies) RalA. RCC2 (show RCC2 Antibodies) and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis.
expression of K-Ras (show HRAS Antibodies) and RalB (show Ralb Antibodies) and possibly RalA proteins is critical for maintaining low levels of p53 (show TP53 Antibodies), and down-regulation of these GTPases reactivates p53 (show TP53 Antibodies) by significantly enhancing its stability, contributing to suppression of malignant transformation
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
RAS-like, family 1
, ral-A protein
, ras-related protein Ral-A
, -ral simian leukemia viral oncogene homolog A (ras related)
, RAS-like protein A
, Ras family small GTP binding protein RALA
, ras related v-ral simian leukemia viral oncogene homolog A