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This study identifies a novel regulatory crosstalk between Ral and Arf6 (show ARF6 ELISA Kits) that controls Ral function in cells.
striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB (show Ralb ELISA Kits).
RalA activation was remarkably impaired in rac1-deficient skeletal muscle fibres.
Our results provide the first in vivo characterization of RalA function in the mammalian brain and highlight a novel molecular mechanism for cell polarization.
The constitutively increased RalA activity occludes further increases in RalA activity during induction of long-term depression, causing impaired NMDAR (show GRIN1 ELISA Kits)-long-term depression.
findings show either RALA or RALB (show Ralb ELISA Kits) is sufficient for tumor growth; either RALA or RALB (show Ralb ELISA Kits) is sufficient for cell proliferation; RALA and RALB (show Ralb ELISA Kits) act in a redundant fashion
study reports the identification and characterization of a Ral GAP complex (RG1 (show PPP1R3A ELISA Kits), RGC2 (show RALGAPA2 ELISA Kits)) that mediates the activation of RalA downstream of the PI 3 (show PI3 ELISA Kits)-kinase/Akt (show AKT1 ELISA Kits) pathway
A novel regulatory pathway involves RalA and phospholipase D (show PLD ELISA Kits) in the production of phosphatidic acid during Fc gamma receptor (show FCGR1A ELISA Kits)-mediated phagocytosis and phagosome formation.
RalA but not RalB (show Ralb ELISA Kits) mediates integrin-dependent membrane raft exocytosis through the exocyst complex. Constitutively active RalA restores membrane raft targeting to promote anchorage-independent growth signaling.
RalA activation elicited by the exchange factor RalGDS (show RALGDS ELISA Kits) in response to a rise in intracellular Ca2 (show CA2 ELISA Kits)+ and cAMP controls hormone release from pancreatic beta-cells
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of the D2R and D3R, through GRK2 and beta-arrestins, respectively. Active RalA was found to interact with GRK2 to sequester it from D2R. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
results suggest that the small GTPase (show RACGAP1 ELISA Kits) RalA plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (show CAV1 ELISA Kits) and FilA but by stimulating PLD2 (show PLD2 ELISA Kits)-mediated generation of phosphatidic acid.
agonist-induced Gbetagamma-mediated conversion of RalA from the GTP (show AK3 ELISA Kits)-bound form to the GDP-bound form could be a mechanism to facilitate agonist-induced internalization of GPCRs.
RCC2 exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase (show RACGAP1 ELISA Kits) RalA. RCC2 and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis.
expression of K-Ras (show HRAS ELISA Kits) and RalB (show Ralb ELISA Kits) and possibly RalA proteins is critical for maintaining low levels of p53 (show TP53 ELISA Kits), and down-regulation of these GTPases reactivates p53 (show TP53 ELISA Kits) by significantly enhancing its stability, contributing to suppression of malignant transformation
These results indicate that MLN8237 treatment may be effective for a subset of patients with PDAC independent of RalA S194 phosphorylation
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 (show SOX9 ELISA Kits) and ACAN (show ACAN ELISA Kits).
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
RAS-like, family 1
, ral-A protein
, ras-related protein Ral-A
, -ral simian leukemia viral oncogene homolog A (ras related)
, RAS-like protein A
, Ras family small GTP binding protein RALA
, ras related v-ral simian leukemia viral oncogene homolog A