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this genetic association study represents the first to show an association of the RASGRF2 G>A (rs26907) polymorphism with Alcoholic Liver Cirrhosis in men, particularly in the subgroup of patients with alcohol dependence. The findings suggest the potential relevance of the RAS gene family in alcoholism and Alcoholic Liver Cirrhosis.
Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF.
these results suggest that betaarrestin1 regulates rasgrf2 gene expression and Rac (show AKT1 Antibodies) activation to affect membrane protrusion and cell migration and invasion.
Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1 (show SDK1 Antibodies), CRTAM (show CRTAM Antibodies) and RASGRF2 genes.
RASGRF2 has a role in the regulation of mesolimbic dopamine neuron activity, reward response, and alcohol use and abuse
Demonstrate a role for RasGRF1 (show RASGRF1 Antibodies)/2 as negative regulators of Cdc42 (show CDC42 Antibodies) activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation.
Farnesylated but not geranylgeranylated TC21 (show RRAS2 Antibodies) can be activated by RasGRF2 due to its pleckstrin (show PLEK Antibodies) homology 1 domain, by a mechanism independent of localization & of its ability to associate to membranes.
These data reveal unexpected negative roles for Vav1 (show VAV1 Antibodies) and RasGRF2 in different stages of T-cell lymphoma progression.
Aberrant methylation of RASGRF2 is associated with human non-small cell lung cancer
These results identify RasGRF2 as an additional component of the signaling machinery involved in T-cell receptor- and NF-AT (show NFATC3 Antibodies)-mediated immune responses.
Nuclear migration in retinal cone photoreceptors is altered in GRF2 knockout mice.
adaptations in the noradrenergic system contribute to the Rasgrf2 enhanced risk of alcoholism.
Findings indicate that GRF2 regulates both the basal level and environmentally induced increase of newborn neuron survival, as well as in the induction of a distinct form of synaptic plasticity of newborn neurons that contributes to learning and memory
These data suggest that Rasgrf2 controls dopaminergic signalling and adaptations to alcohol also in other brain regions, beyond the nucleus accumbens.
Ras-GRF1 (show RASGRF1 Antibodies) and -GRF2 may act as adaptors that bind PLCgamma1 (show PLCG1 Antibodies) and restrict Ca2 (show CA2 Antibodies)+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 (show IL1A Antibodies) induction of the Ras-->ERK (show EPHB2 Antibodies) pathway and MMP-3 (show MMP3 Antibodies) expression
Study demonstrates that NR2A (show GRIN2A Antibodies)-, but not NR2B (show GRIN2B Antibodies), containing NMDA receptors induce LTP (show SCP2 Antibodies) in pyramidal neurons of the CA1 (show CA1 Antibodies) hippocampus from 1 month old mice through Ras-GRF2 and Erk (show EPHB2 Antibodies).
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways.
ras guanine nucleotide exchange factor 2
, ras-specific guanine nucleotide-releasing factor 2
, guanine nucleotide-releasing factor 2
, Ras protein-specific guanine nucleotide-releasing factor 2