Browse our RIT1 Proteins (RIT1)

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Ras-Like Without CAAX 1 Proteins (RIT1)
On are 4 Ras-Like Without CAAX 1 (RIT1) Proteins from 3 different suppliers available. Additionally we are shipping RIT1 Antibodies (67) and RIT1 Kits (3) and many more products for this protein. A total of 83 RIT1 products are currently listed.
MGC79097, NS8, RGD1559874, RIBB, Rit, rit1, ROC1, si:ch211-93a2.3
list all proteins Gene Name GeneID UniProt
Rat RIT1 RIT1 499652  
RIT1 6016 Q92963
RIT1 19769 P70426

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RIT1 Proteins (RIT1) by Origin

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Pig (Porcine) Ras-Like Without CAAX 1 (RIT1) interaction partners

  1. swine UCHL3 (show Uchl3 Proteins), RIT1 and CCND3 (show CCND3 Proteins) genes were differentially expressed in tissues including small intestine, large intestine, liver, muscle, fat, lung, spleen and kidney

Human Ras-Like Without CAAX 1 (RIT1) interaction partners

  1. RIT1 is one of the major genes for NS. The RIT1-associated phenotype differs gradually from other NS subtypes, with a high prevalence of cardiovascular manifestations, especially hypertrophic cardiomyopathy.

  2. Congenital left main coronary artery atresia in a Noonan syndrome is associated with RIT1 variant, leading to unrescued sudden death.

  3. Noonan patients with germline RIT1 mutations are not at high risk to developing JMML or ALL, and that RIT1 has at most a marginal role in these sporadic malignancies.

  4. Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

  5. We report on a 2.5-year-old male patient with clinical signs of NS and hematologic abnormalities, in whom a novel heterozygous substitution in RIT1 with probable pathogenicity was detected.

  6. Mutations in RIT1 cause Noonan syndrome. Mutations in RIT1 affect RAS-MAPK (show MAPK1 Proteins)/MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) signaling. The mutant RIT1 protein may possess reduced GTPase (show RACGAP1 Proteins) activity or a diminished ability to interact with cellular GTPase (show RACGAP1 Proteins) activating proteins.

  7. elevated expression of RIT1 may contribute to the progression of endometrial cancer and thus may serve as a novel prognostic marker and a promising molecular target for the treatment of endometrial cancer.

  8. Because of the relatively high frequency of mutations in RIT1 among patients with NS and its occurrence in different populations, we suggest that it should be added to the list of genes included in panels for the molecular diagnosis of NS.

  9. A genotype-phenotype correlation analysis of available records indicated that germline RIT1 mutations cause a noonan syndrome phenotype characterized by a mild facial appearance.

  10. four additional cases of Noonan syndrome with mutations in RIT1, were identified.

Mouse (Murine) Ras-Like Without CAAX 1 (RIT1) interaction partners

  1. In adult hippocampal neuronal precursor cells, RIT1 controls an Akt (show AKT1 Proteins)-dependent signaling cascade, resulting in the stabilization and transcriptional activation of phosphorylated Sox2 (show SOX2 Proteins). This study supports a role for RIT1 in relaying niche-derived signals to neural/stem progenitor cells to control transcription of genes involved in self-renewal and differentiation

  2. the Rit-p38 (show CRK Proteins)-MSK1 (show RPS6KA5 Proteins)/2 signaling pathway may have an important role in the stress-dependent regulation of CREB (show CREB1 Proteins)-dependent gene expression.

  3. these data identify a new and unexpected role for Rit in injury-induced neurogenesis, functioning as a selective survival mechanism for immature hippocampal neurons within the subgranular zone of the dentate gyrus following TBI (show TBPL1 PLURAL_@42429@).

  4. our studies establish the Rit GTPases as critical regulators of an evolutionarily conserved, p38 MAPK (show MAPK14 Proteins)-dependent signaling cascade

  5. Rin (show RIT2 Proteins) and Rit Bind to PAR6 (show PARD6A Proteins) GTP (show AK3 Proteins)-dependently and regulate cell transformation

RIT1 Protein Profile

Protein Summary

This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with RIT1

  • Ras-like without CAAX 1 (Rit1)
  • Ras-like without CAAX 1 (RIT1)
  • Ras-like without CAAX 1 (RCJMB04_9f23)
  • Ras-like without CAAX 1 (rit1)
  • Ras-like without CAAX 1 (LOC100342642)
  • MGC79097 protein
  • NS8 protein
  • RGD1559874 protein
  • RIBB protein
  • Rit protein
  • rit1 protein
  • ROC1 protein
  • si:ch211-93a2.3 protein

Protein level used designations for Ras-Like Without CAAX 1 Proteins (RIT1)

GTP-binding protein Rit1 , Ras-like without CAAX 1 , GTP-binding protein Roc1 , Ric-like, expressed in many tissues , ras-like protein expressed in many tissues , ras-like without CAAX protein 1 , RAS-like protein expressed in many tissues

499652 Rattus norvegicus
480126 Canis lupus familiaris
533646 Bos taurus
100155905 Sus scrofa
425068 Gallus gallus
446484 Xenopus laevis
457377 Pan troglodytes
717985 Macaca mulatta
768118 Sus scrofa
793942 Danio rerio
100145877 Ovis aries
100342642 Oryctolagus cuniculus
6016 Homo sapiens
19769 Mus musculus
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