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Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter.
RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese.
findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations
performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals
Its polymorphism is associated with Parkinson's disease in a Han Chinese population.
The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology.
failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population.
These studies confirm the expression of RIT2 in retinal neuronal cells.
This meta-analysis identifies a novel Parkinson's disease locus, RIT2, that replicates several previously identified loci on chromosome 18.
Rin interacts directly with dopamine transporter DAT in a protein kinase (PK)C-regulated manner and is required for PKC-mediated DAT internalization.
stimulation of PC6 (show PCSK5 Proteins) cells with either epidermal growth factor (show EGF Proteins) or nerve growth factor (NGF) results in rapid activation of Rin
The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation
Rin and Rit (show RIT1 Proteins) Bind to PAR6 (show PARD6A Proteins) GTP (show AK3 Proteins)-dependently and regulate cell transformation
Neuron-specific small GTPase (show RACGAP1 Proteins) Rin is involved in downstream signaling of plexin B3 (show PLXNB3 Proteins).
RIN belongs to the RAS (HRAS\; MIM 190020) superfamily of small GTPases (Shao et al., 1999
GTP-binding protein Rit2
, GTP-binding protein Roc2
, Ric-like, expressed in neurons
, ras-like protein expressed in neurons
, ras-like without CAAX protein 2
, Ras-like without CAAX 1
, RAS-like protein expressed in neuron
, Ras-like without CAAX 2