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These studies confirm the expression of RIT2 in retinal neuronal cells.
stimulation of PC6 (show PCSK5 Proteins) cells with either epidermal growth factor (show EGF Proteins) or nerve growth factor (NGF) results in rapid activation of Rin
The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation
Rin and Rit (show RIT1 Proteins) Bind to PAR6 (show PARD6A Proteins) GTP (show AK3 Proteins)-dependently and regulate cell transformation
Neuron-specific small GTPase (show RACGAP1 Proteins) Rin is involved in downstream signaling of plexin B3 (show PLXNB3 Proteins).
Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter.
RNF7 (show RNF7 Proteins) gene variant is associated with the risk of developing liver fibrosis and cirrhosis in an Eastern European population.
RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese.
MAF1 (show MAF1 Proteins), RNF7 (show RNF7 Proteins) and SETD3 (show SETD3 Proteins) are identified as PCNA (show PCNA Proteins)-associated proteins in human cells and given this interaction with PCNA (show PCNA Proteins), Maf1 (show MAF1 Proteins), RNF7 (show RNF7 Proteins), and SetD3 (show SETD3 Proteins) are potentially involved in DNA replication, DNA repair, or associated processes.
findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations
performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals
Its polymorphism is associated with Parkinson's disease in a Han Chinese population.
The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology.
These findings indicate that Rbx1 and Rbx2 (show RNF7 Proteins) can both activate Cul5 (show CUL5 Proteins)-Vif (show BTG1 Proteins) E3 ligase in vitro, but they may undergo a more delicate selection mechanism in vivo.
failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population.
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Ras-like without CAAX 2
, GTP-binding protein Rit2
, GTP-binding protein Roc2
, RAS-like protein expressed in neuron
, ras-like protein expressed in neurons
, ras-like without CAAX protein 2
, Ric-like, expressed in neurons
, Ras-like without CAAX 1
, CKII beta-binding protein 1
, RING-box protein 2
, regulator of cullins 2
, sensitive to apoptosis gene protein
, sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
, zinc RING finger protein SAG