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Browse our Ras-Like Without CAAX 2 Proteins (RIT2)

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Ras-Like Without CAAX 2 Proteins (RIT2)
On www.antibodies-online.com are 5 Ras-Like Without CAAX 2 (RIT2) Proteins from 4 different suppliers available. Additionally we are shipping Ras-Like Without CAAX 2 Antibodies (51) and many more products for this protein. A total of 60 Ras-Like Without CAAX 2 products are currently listed.
Synonyms:
CKBBP1, RIBA, RIN, Rit1, RIT2, ROC2, SAG
list all proteins Gene Name GeneID UniProt
RIT2 19762 P70425
RIT2 6014 Q99578
RIT2 291713 Q5BJQ5

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Ras-Like Without CAAX 2 Proteins (RIT2) by Origin

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More Proteins for Ras-Like Without CAAX 2 Interaction Partners

Mouse (Murine) Ras-Like Without CAAX 2 (RIT2) interaction partners

  1. These studies confirm the expression of RIT2 in retinal neuronal cells.

  2. stimulation of PC6 (show PCSK5 Proteins) cells with either epidermal growth factor (show EGF Proteins) or nerve growth factor (NGF) results in rapid activation of Rin

  3. The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation

  4. Rin and Rit (show RIT1 Proteins) Bind to PAR6 (show PARD6A Proteins) GTP (show AK3 Proteins)-dependently and regulate cell transformation

  5. Neuron-specific small GTPase (show RACGAP1 Proteins) Rin is involved in downstream signaling of plexin B3 (show PLXNB3 Proteins).

Human Ras-Like Without CAAX 2 (RIT2) interaction partners

  1. MAF1 (show MAF1 Proteins), RNF7 (show RNF7 Proteins) and SETD3 (show SETD3 Proteins) are identified as PCNA (show PCNA Proteins)-associated proteins in human cells and given this interaction with PCNA (show PCNA Proteins), Maf1 (show MAF1 Proteins), RNF7 (show RNF7 Proteins), and SetD3 (show SETD3 Proteins) are potentially involved in DNA replication, DNA repair, or associated processes.

  2. findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations

  3. performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals

  4. Its polymorphism is associated with Parkinson's disease in a Han Chinese population.

  5. The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology.

  6. These findings indicate that Rbx1 and Rbx2 (show RNF7 Proteins) can both activate Cul5 (show CUL5 Proteins)-Vif (show BTG1 Proteins) E3 ligase in vitro, but they may undergo a more delicate selection mechanism in vivo.

  7. failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population.

  8. These studies confirm the expression of RIT2 in retinal neuronal cells.

  9. This meta-analysis identifies a novel Parkinson's disease locus, RIT2, that replicates several previously identified loci on chromosome 18.

  10. Rin interacts directly with dopamine transporter DAT in a protein kinase (PK)C-regulated manner and is required for PKC-mediated DAT internalization.

Ras-Like Without CAAX 2 (RIT2) Protein Profile

Protein Summary

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with Ras-Like Without CAAX 2 (RIT2)

  • Ras-like without CAAX 2 (RIT2)
  • Ras-like without CAAX 2 (LOC100355294)
  • Ras-like without CAAX 2 (Rit2)
  • ring finger protein 7 (RNF7)
  • CKBBP1 protein
  • RIBA protein
  • RIN protein
  • Rit1 protein
  • RIT2 protein
  • ROC2 protein
  • SAG protein

Protein level used designations for Ras-Like Without CAAX 2 Proteins (RIT2)

Ras-like without CAAX 2 , GTP-binding protein Rit2 , GTP-binding protein Roc2 , RAS-like protein expressed in neuron , ras-like protein expressed in neurons , ras-like without CAAX protein 2 , Ric-like, expressed in neurons , Ras-like without CAAX 1 , CKII beta-binding protein 1 , RING-box protein 2 , rbx2 , regulator of cullins 2 , sensitive to apoptosis gene protein , sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2 , zinc RING finger protein SAG

GENE ID SPECIES
694050 Macaca mulatta
737881 Pan troglodytes
770660 Gallus gallus
100355294 Oryctolagus cuniculus
19762 Mus musculus
6014 Homo sapiens
490475 Canis lupus familiaris
291713 Rattus norvegicus
9616 Homo sapiens
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