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specificity of PDZ domain and the molecular origin
The findings suggest a new role for STEF in Focal adhesion disassembly and cell migration through microtubules-mediated mechanisms.
STEF is an activator of cortical neuronal migration.
Extracellular and intracellular information is integrated by STEF to modulate the balance of Rho GTPase (show RACGAP1 Proteins) activities in the growth cone and control growth cone behavior.
Phosphorylation of STEF by Rho-kinase (show ROCK2 Proteins) exerts the inhibitory effect on the function of STEF.
Results describe the purification, crystallization and X-ray data collection of the Tiam1 (show TIAM1 Proteins) and Tiam2 PH-CC-Ex regions.
Tiam2/Rac (show AKT1 Proteins) are key components of EphB2 (show EPHB2 Proteins) trans-endocytosis and are important for cell repulsion.
Results provide evidence that Sp1 (show PSG1 Proteins) positively controls TIAM2S transcription and that Sp1 (show PSG1 Proteins)-mediated transcriptional activation is essential for TIAM2S ectopic expression in liver cancer cells.
Knockdown of TIAM2 could up-regulate the expression of E-cadherin (show CDH1 Proteins).
TIAM2 expression was undetectable in normal human liver but was induced in all HCC (show FAM126A Proteins) cell lines and in 86% (78/91) of HCC (show FAM126A Proteins) biopsies.
stef gene expressed in a stage- and region-specific manner in the mouse brain
STEF protein is a guanine nucleotide exchange factor that specifically activates Rac1 in vitro and in cultured cells, which may lead to changes in the actin cytoskeletal network.
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.
T-cell lymphoma invasion and metastasis 2
, T-lymphoma invasion and metastasis-inducing protein 2-like
, RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1
, SIF and TIAM1-like exchange factor
, T-cell lymphoma invasion and metastasis 2; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1
, T-lymphoma invasion and metastasis-inducing protein 2