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|Application / Reactivity||Human|
|Blocking Reagent (BR)||1 Antibodies|
|Cellular Assay (CA)||1 Antibodies|
|Dot Blot (DB)||3 Antibodies|
|ELISA (Capture)||5 Antibodies|
|ELISA (Detection)||3 Antibodies|
|Enzyme Immunoassay (EIA)||15 Antibodies|
|Flow Cytometry (FACS)||67 Antibodies|
|Functional Studies (Func)||8 Antibodies|
|Immunoassay (IA)||3 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Immunocytochemistry (ICC)||15 Antibodies|
|Immunoelectron Microscopy (IEM)||1 Antibodies|
|Immunofluorescence (IF)||17 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||13 Antibodies|
|Immunohistochemistry (IHC)||99 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||9 Antibodies|
|Antigen||Interleukin 1, beta (IL1B) Antibodies|
|Epitope||AA 170-269 Alternatives|
|Conjugate||This IL1B antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-IL1B AntibodyTarget Details IL1B Application Details Handling References for anti-IL1B Antibody (ABIN395309) Images
|Specificity||IL1B (AAH08678, 170 a.a. ~ 269 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Purification||This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||IL1B (AAH08678, 170 a.a. ~ 269 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
Target Details IL1BProduct Details anti-IL1B Antibody Application Details Handling References for anti-IL1B Antibody (ABIN395309) Images back to top
|Alternative Name||IL1B (IL1B Antibody Abstract)|
|Background||Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1|
|Molecular Weight||30748 DA|
|Research Area||Cell Cycle, Cell Structure|
|Pathways||NF-kappaB Signaling, TCR Signaling, Interferon-gamma Pathway|
Application DetailsProduct Details anti-IL1B Antibody Target Details IL1B Handling References for anti-IL1B Antibody (ABIN395309) Images back to top
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL1B Antibody Target Details IL1B Application Details References for anti-IL1B Antibody (ABIN395309) Images back to top
|Buffer||PBS with 0.09% (w/v) sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Expiry Date||6 months|
References for anti-IL1B Antibody (ABIN395309)Product Details anti-IL1B Antibody Target Details IL1B Application Details Handling Images back to top
De Iudicibus, Stocco, Martelossi et al.: "Genetic predictors of glucocorticoid response in pediatric patients with inflammatory bowel diseases." in: Journal of clinical gastroenterology, Vol. 45, Issue 1, pp. e1-7, 2010 (PubMed).
Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).
Liu, Chen, Wu et al.: "Association of interleukin-1beta (IL1B) polymorphisms with Graves' ophthalmopathy in Taiwan Chinese patients." in: Investigative ophthalmology & visual science, Vol. 51, Issue 12, pp. 6238-46, 2010 (PubMed).
Cheng, Chang, Wang et al.: "Interleukin-1beta and -10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients." in: Journal of gastroenterology and hepatology, Vol. 25, Issue 8, pp. 1443-51, 2010 (PubMed).
Chen, Cheng: "[Correlation of IL-1beta-511 and IL-1RN VNTR gene polymorphism to coronary heart disease: a meta-analysis]." in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University, Vol. 30, Issue 7, pp. 1635-8, 2010 (PubMed).
ImagesProduct Details anti-IL1B Antibody Target Details IL1B Application Details Handling References for anti-IL1B Antibody (ABIN395309) back to top